Abstract:L ipoprotein(a), or Lp(a), is a low-density lipoprotein (LDL)-like particle. Apolipoprotein B is covalently linked to apolipoprotein(a) by a single disulfide bond [1]. Circulating concentrations of Lp(a) vary widely across individuals and ethnic subgroups, mediated in large part by genetic variations at the LPA gene locus [2]. A meta-analysis of 126,634 participants in 36 prospective studies found that Lp(a) was an independent risk factor for coronary heart disease and stroke [3]. Mendelian randomization studi… Show more
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