High apelin levels could be used as a diagnostic marker in multiple myeloma: A comparative study

Maden, Muhammet; Pamuk, Ömer Nurı; Pamuk, Gülsüm Emel

doi:10.3233/cbm-160654

Cited by 18 publications

(17 citation statements)

References 28 publications

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“…Patients characterized by high tumor apelin expression had a shorter overall survival period than those with low expression [9]. Similar results were obtained in non-small cell lung carcinoma (NSCLC) [10], bladder cancer [11], cholangiocarcinoma (CCA) [12], head and neck cancer [13], prostate cancer [14], ovarian cancer [15], breast cancer [16], oesophageal squamous cell carcinoma [17], multiple myeloma [18], and glioblastoma [19].…”

Section: Introductionmentioning

confidence: 65%

Evaluation of Apelin and Apelin Receptor Level in the Primary Tumor and Serum of Colorectal Cancer Patients

Podgórska

Diakowska

Pietraszek-Gremplewicz

et al. 2019

JCM

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Colorectal cancer is the second deadliest tumor, which has a positive correlation with obesity which led to increasing interest in the relationship between adipokines and cancer progression. Apelin is a secreted peptide involved in regulation of tumor progression and invasiveness. In this study, we examined apelin and apelin receptor expression level in colorectal cancer. Apelin, and its receptor mRNA, and protein expression levels were measured in tumor tissue of 56 surgically treated colorectal adenocarcinoma (CRC) patients. We also analyzed apelin and apelin receptor protein levels in sera of 56 CRC patients and 27 healthy controls. The mRNA and protein level of this peptide and its receptor was higher in tumors than that in control tissue. Serum levels of apelin and apelin receptor were increased in CRC patients in comparison to controls. The concentration of serum apelin level significantly increased in individuals with lymph node and distant metastasis. Obtained results suggest that apelin could be an important factor in progression of colorectal carcinoma.

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Section: Introductionmentioning

confidence: 65%

Evaluation of Apelin and Apelin Receptor Level in the Primary Tumor and Serum of Colorectal Cancer Patients

Podgórska

Diakowska

Pietraszek-Gremplewicz

et al. 2019

JCM

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“…The serum apelin level in hypertensive patients with LVH is significantly lower (Ye et al, 2015). High apelin levels may be used as a diagnostic marker in multiple myeloma (Maden, Pamuk, & Pamuk, 2016).…”

Section: Discussionmentioning

confidence: 98%

“…The serum apelin level in hypertensive patients with LVH is significantly lower (Ye et al, ). High apelin levels may be used as a diagnostic marker in multiple myeloma (Maden, Pamuk, & Pamuk, ). The total expression of apelin are different may due to there are many apelin isoforms.…”

Section: Discussionmentioning

confidence: 99%

ROS‐Autophagy pathway mediates monocytes‐human umbilical vein endothelial cells adhesion induced by apelin‐13

Liu

Zhou

et al. 2018

Journal Cellular Physiology

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Apelin is the endogenous ligand of APJ receptor. Both monocytes (MCs) and human umbilical vein endothelial cells (HUVECs) express apelin and APJ, which play important roles in the physiological processes of atherosclerosis. Our previous research indicated that apelin-13 promoted MCs-HUVECs adhesion. Here, we further explore the mechanism responsible for MCs-HUVECs adhesion induced by apelin-13. Apelin-13 promoted reactive oxygen species (ROS) generation and NOX4 expression in HUVECs. Apelin-13 inducedautophagy, increased proteins beclin1 and LC3-II/I expression and induced autophagy flux in HUVECs, which was blocked by NAC, catalase and DPI. Autophagy flux induced by apelin-13 was inhibited by NAC and catalase but not hydroxychloroquine (HCQ). NAC, catalase, and DPI prevented apelin-13 induced ICAM-1 expression in HUVECs. Rapamycin enhanced MCs-HUVECs adhesion that was reversed by NAC, catalase, and DPI. Down-regulation of beclin1 and LC3 by siRNA blocked MCs-HUVECs adhesion. Apelin-13 induced atherosclerotic plaque and increased NOX4, LC3-II/I expression in ApoE-/-(HFD) mouse model. Our results demonstrated that apelin-13 induced MCs-HUVECs adhesion via a ROS-autophagy pathway.

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“…In postmenopausal breast cancer patients, the serum apelin-36 level was increased compared to the control group and was positively correlated with BMI (Salman et al, 2016 ). In multiple myeloma patients, plasma apelin level was significantly increased, relative to a healthy control group (Maden et al, 2017 ).…”

Section: Apelin In Cancermentioning

confidence: 99%

The Role of Apelin in Cardiovascular Diseases, Obesity and Cancer

Wysocka

Pietraszek-Gremplewicz

2018

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Apelin is an endogenous peptide identified as a ligand of the G protein-coupled receptor APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by adipose tissue. Extensive tissue distribution of apelin and its receptor suggests, that it could be involved in many physiological processes including regulation of blood pressure, body fluid homeostasis, endocrine stress response, cardiac contractility, angiogenesis, and energy metabolism. Additionally, this peptide participates in pathological processes, such as heart failure, obesity, diabetes, and cancer. In this article, we review current knowledge about the role of apelin in organ and tissue pathologies. We also summarize the mechanisms by which apelin and its receptor mediate the regulation of physiological and pathological processes. Moreover, we put forward an indication of apelin as a biomarker predicting cardiac diseases and various types of cancer. A better understanding of the function of apelin and its receptor in pathologies might lead to the development of new medical compounds.

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High apelin levels could be used as a diagnostic marker in multiple myeloma: A comparative study

Abstract: In MM, plasma apelin level was significantly higher than in NHL and control groups. Apelin could be playing a role in MM pathogenesis; and apelin level could be used as a diagnostic and prognostic biomarker in MM.

Cited by 18 publications

References 28 publications

Evaluation of Apelin and Apelin Receptor Level in the Primary Tumor and Serum of Colorectal Cancer Patients

Evaluation of Apelin and Apelin Receptor Level in the Primary Tumor and Serum of Colorectal Cancer Patients

ROS‐Autophagy pathway mediates monocytes‐human umbilical vein endothelial cells adhesion induced by apelin‐13

The Role of Apelin in Cardiovascular Diseases, Obesity and Cancer

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