High Antihaemophilic Factor in Multiple Myeloma

Propp, Simon; Dylong, Vivian M.

doi:10.1038/207206a0

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…It seems unlikely that thalidomide itself induces the high FVIII:C/VWF‐Ag because significant higher levels of both factors were found in all patients with active disease, irrespective of thalidomide treatment, as compared with patients in plateau phase. High FVIII:C levels in myeloma have already been described in 1965 [13]. One report in 1976 suggested a relation between the degree of bone marrow involvement as assessed by radiological skeletal survey and the level of FVIII:C [14].…”

Section: Discussionmentioning

confidence: 99%

Extremely high levels of von Willebrand factor antigen and of procoagulant factor VIII found in multiple myeloma patients are associated with activity status but not with thalidomide treatment

Minnema

Fijnheer

Groot

et al. 2003

Journal of Thrombosis and Haemostasis

105

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Summary. Venous thromboembolism (VTE) is a major complication in patients with multiple myeloma (MM) during treatment with thalidomide combined with chemotherapy and/or dexamethasone. The pathophysiology is not clear. We performed a cross-sectional study in 20 MM patients who were treated with thalidomide for refractory/relapsed disease. Seven patients (35%) experienced an episode of VTE. Plasma samples were analyzed for known risk factors for VTE and compared with those from 30 MM patients without thalidomide treatment. The patients groups differed in their baseline characteristics in activity status only. Extremely high levels of factor VIII-coagulant activity (FVIII:C, mean 352%) and von Willebrand factor antigen (VWF-Ag, 374%) were found in all patients using thalidomide. All other prothrombotic risk factors were normal. In patients with VTE, VWF-Ag but not FVIII:C, levels were significantly higher as compared with patients without VTE. Patients without thalidomide treatment had significantly lower levels of both coagulation factors but the difference was only due to difference in activity status. High FVIII:C/VWF-Ag levels are found in patients with active MM and this is probably a reflection of increased bone marrow angiogenesis in MM. These prothrombogenic circumstances could contribute to the high incidence of VTE during treatment with thalidomide in combination with dexamethasone/chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Extremely high levels of von Willebrand factor antigen and of procoagulant factor VIII found in multiple myeloma patients are associated with activity status but not with thalidomide treatment

Minnema

Fijnheer

Groot

et al. 2003

Journal of Thrombosis and Haemostasis

105

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“…Elevated levels of Factor VIII have been observed in the plasma of patients with myeloma. 112 The significance of these observations remains unclear.…”

Section: Factor VIII In Myeloma and Related Disordersmentioning

confidence: 99%

Disturbances in Hemostasis in Patients with B-Cell Malignancies

Glaspy¹

1992

Semin Thromb Hemost

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“…Elevation of F VIII levels has, indeed, been reported in a number of physiological and pathological conditions as exercise [19], fever of unknown origin [3], pregnancy [23], use of oral contraceptives [4], hyperthyroidism [5,8], diabetes [6], intravascular hemolysis [7], Cushing's syndrome [13], and multiple myeloma [12,15,27]. High levels of F VIII have been pointed out as a feature of hypercoagulable plasmas [14].…”

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confidence: 99%

Elevation of Factor VIII in Acute Liver Necrosis

et al. 1973

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The results of clotting tests during plasmapheresis in 3 cases of acute viral liver necrosis are reported. Elevated F VIII levels were found in all cases before the start of plasmapheresis. During plasmapheresis, a decrease of F VIII activity was found in 2 cases. In the third patient with persistently high F VIII levels during several days of plasmapheresis, disseminated intravascular coagulation may have been present. The mechanisms of the elevation of F VIII in acute viral liver necrosis and the influence of plasmapheresis on F VIII levels are discussed.

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High Antihaemophilic Factor in Multiple Myeloma

Cited by 8 publications

References 10 publications

Extremely high levels of von Willebrand factor antigen and of procoagulant factor VIII found in multiple myeloma patients are associated with activity status but not with thalidomide treatment

Extremely high levels of von Willebrand factor antigen and of procoagulant factor VIII found in multiple myeloma patients are associated with activity status but not with thalidomide treatment

Disturbances in Hemostasis in Patients with B-Cell Malignancies

Elevation of Factor VIII in Acute Liver Necrosis

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