High Anticancer Properties of Defatted <i>Jatropha Curcus</i> Seed Residue and its Active Compound, Isoamericanol A

Katagi, Ayako; Sui, Li; Kamitori, Kazuyo; Suzuki, Toshisada; Katayama, Takuya; Hossain, Akram; Noguchi, Chisato; Dong, Yan; Yamaguchi, Fuminori; Tokuda, Masaaki

doi:10.1177/1934578x1701201217

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…Although generally considered an invasive species, pokeweed has multiple uses, with various bioactive compounds discovered in diferent pokeweed parts. Neolignans, such as americanin A and isoamericanol A, isolated from pokeweed seeds showed antibreast and colon cancer activities [8][9][10]. Pokeweed storage roots contain triterpenoid saponins that possess useful bioactivities, such as anticancer and antifungal activities.…”

Section: Introductionmentioning

confidence: 99%

The Optimization of Medium Conditions and Auxins in the Induction of Adventitious Roots of Pokeweed (Phytolacca americana L.) and Their Phytochemical Constituents

Trunjaruen,

Luecha,

Taratima

2023

Scientifica

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Pokeweed, Phytolacca americana L., is considered a widely spreading invasive plant, while saponin contents accumulated in the roots have pharmaceutical uses, such as rheumatism treatments and anti-inflammation. Adventitious root cultures are an important source of diverse secondary metabolites, which have significant applications in various fields. This study focused on the optimization of parameters for root induction using different medium states and treatments with auxins on a pokeweed leaf. Semisolid and liquid MS (Murashige and Skoog, 1962) media were supplemented with indole-3-butyric acid (IBA) and 1-naphthylacetic acid (NAA) at 0.5, 1, 2, and 4 mg/L. Root growth parameters, e.g., induction percentage, root numbers, length, and weight, were measured to determine the adventitious root induction efficiency. Total phenolic content, total flavonoid content, total saponin content, and antioxidant activity were recorded. Results showed that adventitious roots induced in semisolid MS medium supplemented with 0.5 mg/L NAA exhibited a high density of lateral roots. Appropriate medium state and auxin for adventitious root induction in pokeweed were determined as semisolid medium supplemented with 2 mg/L NAA. Considering phytochemicals, adventitious roots induced in liquid medium containing 0.5–1 mg/L NAA had the highest yield extract percentage. Additionally, adventitious roots cultivated in a liquid medium enriched with 1 mg/L NAA exhibited the highest phenolic and saponin contents. A principal component analysis (PCA) biplot and hierarchical cluster analysis (HCA) heatmap demonstrated different response patterns between semisolid and liquid media applied with NAA. The results of the semisolid media were grouped together due to high expression levels of the root induction parameters, while elevated phytochemical values were observed in the liquid media treatments. The results suggested two different media that provide the highest adventitious root induction efficiency and the greatest phytochemical contents: semisolid medium with 2 mg/L NAA and liquid medium with 1 mg/L NAA, respectively. These culture media can be applied to optimize adventitious root culture of pokeweed and in vitro phytochemical production.

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Section: Introductionmentioning

confidence: 99%

The Optimization of Medium Conditions and Auxins in the Induction of Adventitious Roots of Pokeweed (Phytolacca americana L.) and Their Phytochemical Constituents

Trunjaruen,

Luecha,

Taratima

2023

Scientifica

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“…Studies carried out on the nutraceutical values of this plant showed the abundant presence of bioactive phytoconstituents like flavonoids (3.69%) and alkaloids (1.89%) and essential minerals such as calcium (5.69%), magnesium (4.22%) and potassium (2.15%) (Arum et al, 2014). Katagi et al (2017) reported that organic and water fractions of EtOAc and MeOH extracts from defatted J. curcas seed residue were effective inhibitors of hepatocellular and breast cancer cell growth. According to Arum et al (2014) and Asep et al (2017), J. tanjorensis and J. gossipifolia are good anticancer plant species.…”

Section: Introductionmentioning

confidence: 99%

Taxonomic implications of foliar epidermal anatomy of Jatropha tanjorensis J.L. Ellis & Saroja and its putative parents

Nwankwo¹,

Odewo²,

Ajani³

et al. 2022

njbot

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This study was aimed to determine the relationship among three Jatropha taxa for their reliable identification. Data from reviews showed that J. curcas and J. gossipifolia are the putative parents of J. tanjorensis. Standard method of using Premier Light Microscope, concentrated Trioxonitrate (V) acid, Petri dishes, Methyl-blue and glycerol was employed to carry out the study. Results of the study showed that the three taxa possessed paracytic stomata on both surfaces except in J. gossipifolia where the stomata were only observed on abaxial surface. The cell shape was oblong in J. tanjorensis with undulate anticlinal wall patterns. In J. curcas and J. gossipifolia, the cell shapes and anticlinal wall patterns were irregular and straight, respectively. The stomatal length of the taxa ranged from 11.2 μm to 43.0 μm while the cell length was from 25.0 μm to 84.0 μm. The oblong cell shape and undulate anticlinal walls of J. tanjorensis are its diagnostic characters while the irregular cell shape and amphistomatic leaves are the diagnostic features of J. curcas. Absence of stomata on the adaxial surface with irregular cell shape is unique to J. gossipifolia. The data obtained could be used in conjunction with other characters for reliable identification of the three taxa.

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“…The lignans, which may have been generated from the oxidative coupling of caffeyl alcohol or caffeic acid, have shown interesting physiological activities. Isoamericanol A has been reported to show neurotrophic activity on rat cells [7], antimelanogenic activity on Melan-a cells [8], anticancer activity on human breast cancer cell lines [9][10][11], as well as plant growth inhibitory activity [12]. Furthermore, isoamericanin A was isolated as a prostaglandin I 2 inducer [13], and (+)-3,3′-bisdemethylpinoresinol has been reported as a metabolite of (+)-sesamin in rat liver homogenate [14,15].…”

Section: Introductionmentioning

confidence: 99%

A catechol-type lignan and neolignans are specifically present in the seed coat of tung trees

et al. 2020

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The tung tree produces large seeds with approximately 40-50% of their composition consisting of non-edible oil. α-Eleostearic acid makes up about 80% of tung oil, while linoleic acid and oleic acid make up 7 and 6%, respectively. The oil is readily oxidized due to the three, conjugated double bonds in α-eleostearic acid; however, it is stable inside the tung seed, which is expected to contain strong antioxidative compounds that protect the oil from oxidation. Previously, we isolated and identified a catechol-type lignan (3,3′-bisdemethylpinoresinol) and neolignans (isoamericanol A and americanol A) from the seeds of tung tree fruits that exhibited strong antioxidative activity, similar to that of Trolox. In this study, we show that the catechol-type lignan and neolignans are specifically present in the seed coat of the tung tree fruit seeds. The lignans were not detected in any other tissue, such as the pericarp, bark, leaves, or wood of the tree. The lignan content was determined in each developmental stage of the fruit, and the amount of the three lignans in the tung seeds was the highest in the green mature stage. This was likely because the amount of tung oil was also at its highest during this stage, and the oil composition was stable. Our results indicate that the catecholtype lignan and neolignans are located within the seed coat of the tung tree fruit seeds, where they protect the oil in the endosperm from autoxidation and polymerization processes.

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High Anticancer Properties of Defatted Jatropha Curcus Seed Residue and its Active Compound, Isoamericanol A

Cited by 5 publications

References 11 publications

The Optimization of Medium Conditions and Auxins in the Induction of Adventitious Roots of Pokeweed (Phytolacca americana L.) and Their Phytochemical Constituents

The Optimization of Medium Conditions and Auxins in the Induction of Adventitious Roots of Pokeweed (Phytolacca americana L.) and Their Phytochemical Constituents

Taxonomic implications of foliar epidermal anatomy of Jatropha tanjorensis J.L. Ellis & Saroja and its putative parents

A catechol-type lignan and neolignans are specifically present in the seed coat of tung trees

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