High‐ and normal‐protein diets improve body composition and glucose control in adults with type 2 diabetes: a randomized trial

Clina, Julianne G.; Sayer, R. Drew; Pan, Zhaoxing; Cohen, Caroline W.; McDermott, Michael T.; Catenacci, Victoria A.; Wyatt, Holly R.; Hill, James O.

doi:10.1002/oby.23815

Cited by 3 publications

(3 citation statements)

References 36 publications

(45 reference statements)

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“…Some studies showed that increasing protein intake during energy-restricted diets has beneficial effects on body composition and the preservation of lean body mass (LBM) [ 13 , 14 , 17 , 22 , 23 , 24 ]. In contrast, we found that an increased protein intake of 1.5 g as compared to 1 g per kilogram of normalized weight neither affected weight loss nor LBM loss in the course of a 12-week multimodal treatment for morbid obesity with a formula-based diet of 800–1000 kcal per day.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies provided inconsistent results. Some found that increased protein intake during caloric restriction helps maintain LBM compared to normal protein intake [ 13 , 14 , 15 ], especially when combined with physical activity [ 16 , 17 ]. However, other studies have failed to show the positive impact of additional protein intake [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Additional Protein Intake on Lean Body Mass in Patients Undergoing Multimodal Treatment for Morbid Obesity

Stein,

Sauer,

Oberänder

et al. 2024

Nutrients

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(1) Multimodal treatment is a standard treatment for patients with obesity. However, weight loss also leads to reductions in fat-free mass. The aim was to investigate whether additional protein intake contributes to better preservation of lean body mass (LBM). (2) A total of 267 obesity patients (age 45.8 years; BMI 47.3 kg/m2) were included in this analysis. For the first 12 weeks of the program, patients were given a formula-based diet of 800–1000 kcal per day. Patients were divided into a control group (CG) (n = 148) and a protein group (PG) (n = 119). The PG was characterized by an additional protein intake with the aim of consuming 1.5 g of protein per kilogram of normalized body weight, whereas the CG had a protein intake of 1 g/kg/d. Bioelectrical impedance analysis was performed at the beginning (t0) and after 12 weeks (t1) of the program. (3) There were no significant differences between the groups with respect to weight loss (p = 0.571). LBM was also significantly reduced in both groups, without significant differences between CG and PG. (4) Increased protein intake had no significant effect on body composition of morbidly obese patients during a 12-week formula-based diet and multimodal treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Additional Protein Intake on Lean Body Mass in Patients Undergoing Multimodal Treatment for Morbid Obesity

Stein,

Sauer,

Oberänder

et al. 2024

Nutrients

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“…Other approaches, including time-restricted eating[ 11 ] and even high-protein diets[ 12 ], have successfully induced remission.…”

Section: Intensive Lifestyle Interventions For T2dm Remissionmentioning

confidence: 99%

Remission of type 2 diabetes mellitus

Nakhleh,

Halfin,

Shehadeh

2024

World J Diabetes

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The surge in type 2 diabetes mellitus (T2DM) is tightly linked to obesity, leading to ectopic fat accumulation in internal organs. Weight management has become a cornerstone of T2DM treatment, with evidence suggesting that significant weight loss can induce remission. Remission, defined as sustained hemoglobin (HbA1c) below 6.5% for at least 3 months without medication, can be achieved through various approaches, including lifestyle, medical, and surgical interventions. Metabolic bariatric surgery offers significant remission rates, particularly for patients with severe obesity. Intensive lifestyle modifications, including low-calorie diets and exercise, have also demonstrated significant potential. Medications like incretin-based agents show robust results in improving beta-cell function, achieving glycemic control, and promoting weight loss. While complete remission without medication may not be attainable for everyone, especially those with severe insulin resistance or deficiency, early and aggressive glycemic control remains a crucial strategy. Maintaining HbA1c below 6.5% from the time of diagnosis reduces the risk of long-term complications and mortality. Moreover, considering a broader definition of remission, encompassing individuals with sustained control on medication, could offer a more comprehensive and inclusive approach to managing this chronic disease.

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Body Size Measurements Grouped Independently of Common Clinical Measures of Metabolic Health: An Exploratory Factor Analysis

Ellison,

El Zein,

Reynolds

et al. 2024

Nutrients

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Background: Obesity is commonly aggregated with indices of metabolic health. Proponents of body positivity approaches question whether body size is a determinant of health and well-being. Our objective was to conduct an exploratory factor analysis (EFA) to determine if body size measurements factor load with or independent of metabolic health measures. Methods: The EFA was conducted on n= 249 adults using baseline data from four weight loss trials (Sample 1: n = 40; Sample 2: n = 52; Sample 3: n = 53; Sample 4: n = 104). An EFA of nine items (systolic blood pressure [SBP], diastolic blood pressure [DBP], hemoglobin A1c [HbA1c], HDL-cholesterol [HDL], LDL-cholesterol [LDL], total cholesterol [TC], body mass index [BMI], body fat percent BF%], and waist circumference [WC]) was conducted with oblique rotation. Results: Three factors were retained, which produced a model explaining 87.5% of the variance. Six items loaded strongly (>0.8) under three components and were selected for retention (Factor 1: LDL and TC; Factor 2: BMI and WC; Factor 3: SBP and DBP). Conclusion: Body size measures loaded separately from measures of metabolic health and metabolic health were further split into lipid- and blood pressure-focused factors. These results support weight-neutral interventions to improve overall health and well-being.

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High‐ and normal‐protein diets improve body composition and glucose control in adults with type 2 diabetes: a randomized trial

Cited by 3 publications

References 36 publications

Effects of Additional Protein Intake on Lean Body Mass in Patients Undergoing Multimodal Treatment for Morbid Obesity

Effects of Additional Protein Intake on Lean Body Mass in Patients Undergoing Multimodal Treatment for Morbid Obesity

Remission of type 2 diabetes mellitus

Body Size Measurements Grouped Independently of Common Clinical Measures of Metabolic Health: An Exploratory Factor Analysis

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