High-Altitude Treatment in Rhinitis Patients

Kang, GuanYang

doi:10.1177/1945892419875591

Cited by 1 publication

(3 citation statements)

References 5 publications

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“…AACT has also been shown to result in improvements in sinonasal symptoms in patients with severe asthma (Table 3E) 10,143 . In fact, AACT has recently been suggested as treatment for allergic rhinitis and chronic rhinosinusitis as well 150 …”

Section: Clinical Impact Of Alpine Altitude Climate Treatment In Adultsmentioning

confidence: 99%

“… 10 , 143 In fact, AACT has recently been suggested as treatment for allergic rhinitis and chronic rhinosinusitis as well. 150 …”

Section: Clinical Impact Of Alpine Altitude Climate Treatment In Adultsmentioning

confidence: 99%

“…Observational studies of AACT show improvement in • lung function (FEV1%predicted) 7,[167][168][169][170] • asthma control (ACQ) 10,138,142,143 • quality of life (AQLQ) 10,138,142,143 • sinonasal symptoms (SNOT) 10,143,150 • exercise tolerance (6MWD, ISWT) 10,138,143,168 • OCS requirements and SABA overuse 10,[141][142][143]147 • Clinical improvement after AACT is irrespective of asthma phenotype [9][10][11] • AACT results in sustained long-term (12 months) asthma control 142,143 • AACT compared to treatment at sea level shows a larger improvement in asthma control and OCS dependency Abbreviations: AACT: alpine altitude climate treatment, 6MWD: 6-min walking distance, ISWT: incremental shuttle walk test, m: meters above sea level, and OCS: oral corticosteroids including furniture, carpets, and available food. 62 There are several sampling techniques to assess residential exposure to HDM, collecting either airborne dust or settled dust.…”

Section: Observed Effects Open Questionsmentioning

confidence: 99%

See 2 more Smart Citations

Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper

Fieten

Drijver-Messelink

Cogo

et al. 2022

Allergy

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Currently available European Alpine Altitude Climate Treatment (AACT) programs combine the physical characteristics of altitude with the avoidance of environmental triggers in the alpine climate and a personalized multidisciplinary pulmonary rehabilitation approach. The reduced barometric pressure, oxygen pressure, and air density, the relatively low temperature and humidity, and the increased UV radiation at moderate altitude induce several physiological and immunological adaptation responses. The environmental characteristics of the alpine climate include reduced aeroallergens such as house dust mites (HDM), pollen, fungi, and less air pollution. These combined factors seem to have immunomodulatory effects controlling pathogenic inflammatory responses and favoring less neuro‐immune stress in patients with different asthma phenotypes. The extensive multidisciplinary treatment program may further contribute to the observed clinical improvement by AACT in asthma control and quality of life, fewer exacerbations and hospitalizations, reduced need for oral corticosteroids (OCS), improved lung function, decreased airway hyperresponsiveness (AHR), improved exercise tolerance, and improved sinonasal outcomes. Based on observational studies and expert opinion, AACT represents a valuable therapy for those patients irrespective of their asthma phenotype, who cannot achieve optimal control of their complex condition despite all the advances in medical science and treatment according to guidelines, and therefore run the risk of falling into a downward spiral of loss of physical and mental health. In the light of the observed rapid decrease in inflammation and immunomodulatory effects, AACT can be considered as a natural treatment that targets biological pathways.

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Section: Clinical Impact Of Alpine Altitude Climate Treatment In Adultsmentioning

confidence: 99%

“… 10 , 143 In fact, AACT has recently been suggested as treatment for allergic rhinitis and chronic rhinosinusitis as well. 150 …”

Section: Clinical Impact Of Alpine Altitude Climate Treatment In Adultsmentioning

confidence: 99%

Section: Observed Effects Open Questionsmentioning

confidence: 99%

See 1 more Smart Citation

Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper

Fieten

Drijver-Messelink

Cogo

et al. 2022

Allergy

View full text Add to dashboard Cite

show abstract

High-Altitude Treatment in Rhinitis Patients

Cited by 1 publication

References 5 publications

Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper

Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper

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