High-Altitude Pulmonary Edema in the Children and Young Adults of Leadville, Colorado

Scoggin, Charles H.; Hyers, Tom M.; Reeves, John Τ.; Grover, Robert F.

doi:10.1056/nejm197712082972309

Cited by 114 publications

(57 citation statements)

References 9 publications

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“…561 Unlike SHPAH, which is rare, HAPE is common and afflicts people residing in or visiting the Rocky Mountains and other high-altitude resorts. [565][566][567] The are 2 types of HAPE: that which afflicts lowlanders who rapidly ascend to altitudes above 2500 m (although lower altitudes have been associated with HAPE 568 ) and re-entry HAPE, which occurs in high-altitude residents who return to high altitude after sojourning (for as little as a day) to low altitude. 565 The more rapidly one gains altitude above 2500 m, the greater the susceptibility to HAPE is (see below).…”

Section: High-altitude Pulmonary Edemamentioning

confidence: 99%

“…[565][566][567] The are 2 types of HAPE: that which afflicts lowlanders who rapidly ascend to altitudes above 2500 m (although lower altitudes have been associated with HAPE 568 ) and re-entry HAPE, which occurs in high-altitude residents who return to high altitude after sojourning (for as little as a day) to low altitude. 565 The more rapidly one gains altitude above 2500 m, the greater the susceptibility to HAPE is (see below). The incidence of HAPE with rapid ascent to 4559 m is 7% in mountaineers without previous HAPE but 62% in those with a prior episode.…”

Section: High-altitude Pulmonary Edemamentioning

confidence: 99%

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Pediatric Pulmonary Hypertension

Abman¹,

Hansmann²,

Archer³

et al. 2015

Circulation

930

405

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Abstract-Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic diseases in neonates, infants, and older children and contributes to significant morbidity and mortality. However, current approaches to caring for pediatric patients with pulmonary hypertension have been limited by the lack of consensus guidelines from experts in the field. In a joint effort from the American Heart Association and American Thoracic Society, a panel of experienced clinicians and clinician-scientists was assembled to review the current literature and to make recommendations on the diagnosis, evaluation, and treatment of pediatric pulmonary hypertension. This publication presents the results of extensive literature reviews, discussions, and formal scoring of recommendations for the care of children with pulmonary hypertension. Key Words: AHA Scientific Statements ◼ bronchopulmonary dysplasia ◼ congenital diaphragmatic hernia ◼ congenital heart disease ◼ genetics ◼ persistent pulmonary hypertension of the newborn ◼ sickle cell disease © 2015 by the American Heart Association, Inc., and the American Thoracic Society.Circulation is available at http://circ.ahajournals.org DOI: 10.1161/CIR.0000000000000329 †Deceased. The American Heart Association and the American Thoracic Society make every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.This document was approved by the American Heart Association Science Advisory and Coordinating Committee on May 12, 2015, the American Heart Association Executive Committee on July 22, 2015, and the American Thoracic Society on July 24, 2015.The online-only Data Supplement is available with this article at http://circ.ahajournals.org/lookup/suppl/doi:10.1161/CIR.0000000000000329/-/DC1. The American Heart Association requests that this document be cited as follows: Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL; on behalf of the American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation, Council on Clinical Cardiology, Council on Cardiovascular Disease in the Young, Council on Cardiovascular Radiology and Intervention, Council on Cardiovascular Surgery and Anesthesia, and the American Thoracic Society. Pediatric pulmonary hypertension: guidelines from the American Heart Association and American Thoracic Society. Circulation. 2015;132:2037-2099 Copies: This document is available on the World Wide Web site of the American Heart Associat...

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Section: High-altitude Pulmonary Edemamentioning

confidence: 99%

Section: High-altitude Pulmonary Edemamentioning

confidence: 99%

Pediatric Pulmonary Hypertension

Abman¹,

Hansmann²,

Archer³

et al. 2015

Circulation

930

405

View full text Add to dashboard Cite

show abstract

“…Workers in the Andes (Vega, 1955;Hultgren, Spickard, Hellriegel & Houston, 1961;Marticorena, Tapia, Dyer, Severino, Banchero, Gamboa, Kruger & Penaloza, 1964) and Colorado (Scoggin, Hyers, Reeves & Grover, 1977) have found that children experience high altitude pulmonary oedema more often than adults and that high altitude pulmonary oedema is confined almost exclusively to native highlanders re-ascending to altitude after a sojourn of variable duration at sea-level. However, others have shown conclusively that high altitude pulmonary oedema is by no means rare in lowlanders exposed for the first time to altitude (Houston, 1960;Fred, Schmidt, Bates & Hecht, 1962;Singh et al, 1965).…”

Section: High Altitude Pulmonary Oedema In Contextmentioning

confidence: 99%

Altitude and the Human Pulmonary Circulation

Lockhart

Saiag

1981

Clinical Science

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“…However, the prevalence of high-altitude pulmonary oedema (HAPE) may differ between adults and children, despite some contradictory evidence [1]. Children residing at high altitude are more likely to develop HAPE [2,3] when returning to high altitude after a lowland stay.…”

mentioning

confidence: 99%

Higher pulmonary artery pressure in children than in adults upon fast ascent to high altitude

Kriemler¹,

Jansen²,

Linka³

et al. 2008

Eur Respir J

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The response of pulmonary artery pressure to high altitude has not been studied in children. It is also not known whether the individual response is hereditary. Therefore, the response of pulmonary artery pressure to high altitude was measured in pre-pubertal children in comparison to that in their biological fathers.Echocardiography was performed at 450 m and over 3 days at 3,450 m. Systolic pulmonary artery pressure was estimated from the pressure gradient of tricuspid regurgitation.The increase in pulmonary artery pressure in children was greater than that in adults at day 1 of high altitude (15.5¡9.1 versus 7.9¡6.4 mmHg), but returned to adult levels on day 2. The increase in pulmonary artery pressure from low to high altitude of each child correlated with that in the father.Pre-pubertal children transiently develop greater pulmonary hypertension than their fathers when exposed to high altitude. The individual response of pulmonary pressure to high altitude seems to be at least partly hereditary.

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High-Altitude Pulmonary Edema in the Children and Young Adults of Leadville, Colorado

Cited by 114 publications

References 9 publications

Pediatric Pulmonary Hypertension

Pediatric Pulmonary Hypertension

Altitude and the Human Pulmonary Circulation

Higher pulmonary artery pressure in children than in adults upon fast ascent to high altitude

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