High altitude is not a risk factor for type 2 diabetes mellitus

Calderón-Gerstein, Walter

doi:10.1016/j.diabres.2016.11.018

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Such physiological models were also established in Drosophila and C. elegans but were achieved by gene knockout or diet induction 49 , 50 . Hypoxia can inhibit insulin signaling and induce insulin resistance in adipose tissues originating from obese human or murine 51 , although some studies have reported that high altitude is not a risk factor for insulin resistance-induced type-2 diabetes mellitus in humans 52 . Thus locusts are a potential model for insulin resistance-related obesity studies.…”

Section: Discussionmentioning

confidence: 99%

Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts

Ding

Liu

et al. 2018

Nat Commun

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Animal and human highlanders have evolved distinct traits to enhance tissue oxygen delivery and utilization. Unlike vertebrates, insects use their tracheal system for efficient oxygen delivery. However, the genetic basis of insect adaptation to high-altitude hypoxia remains unexplored. Here, we report a potential mechanism of metabolic adaptation of migratory locusts in the Tibetan Plateau, through whole-genome resequencing and functional investigation. A genome-wide scan revealed that the positively selected genes in Tibetan locusts are predominantly involved in carbon and energy metabolism. We observed a notable signal of natural selection in the gene PTPN1, which encodes PTP1B, an inhibitor of insulin signaling pathway. We show that a PTPN1 coding mutation regulates the metabolism of Tibetan locusts by mediating insulin signaling activity in response to hypoxia. Overall, our findings provide evidence for the high-altitude hypoxia adaptation of insects at the genomic level and explore a potential regulatory mechanism underlying the evolved metabolic homeostasis.

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Section: Discussionmentioning

confidence: 99%

Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts

Ding

Liu

et al. 2018

Nat Commun

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“…A recent study reported an odds ratio (OR) of 0.88 for T2 DM among those living 1,500-3,500 m above sea level (4). In addition, some studies reported that residents in high-altitude areas have lower glycemic levels than residents in sea-level areas (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Features of Glycemic Levels and Relative Determinants at Different Altitudes Among Tibetans in China: A Cross-Sectional Population-Based Study

Lin

Liu

et al. 2020

Front. Public Health

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Risk factors associated with diabetes mellitus have been widely researched worldwide, but the determinants of glycemic levels among Tibetans in China are currently unclear. We thus aimed to determine the relationship between altitude and glycemic levels and to identify factors associated with glycemic levels among Tibetans in China. In 2011, a total of 1,659 Tibetans (aged ≥18 years) from Changdu, China, were enrolled to this cross-sectional research. Potential factors associated with postprandial glucose (PPG), fasting plasma glucose (FPG), and insulin (INS) levels were assessed. FPG and PPG levels increased with age and total cholesterol (TC) level. In addition, FPG levels were higher among patients with rural residence and hypertension, while PPG levels increased with increasing BMI. INS levels increased with residence, lower education, higher BMI, and higher TG levels and decreased with higher altitude and TC levels. Moreover, risk factors for FPG, PPG, and INS differed in those residing at a higher altitude. These findings identify several important risk factors that affect glycemic levels and may be used to develop effective strategies for metabolic disease prevention among populations in high-altitude areas. Furthermore, these findings suggest that it is necessary to formulate a standard for PPG, FPG, and INS in high-altitude areas.

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High altitude is not a risk factor for type 2 diabetes mellitus

Cited by 2 publications

References 7 publications

Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts

Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts

Epidemiological Features of Glycemic Levels and Relative Determinants at Different Altitudes Among Tibetans in China: A Cross-Sectional Population-Based Study

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