High altitude-induced borderline pulmonary hypertension impaired cardiorespiratory fitness in healthy young men

Yang, Te; Li, Xiangjun; Qin, Jun; Li, Shuangfei; Yu, Jie; Zhang, Jihang; Yu, Shanshan; Wu, Xiaojing; Huang, Lan

doi:10.1016/j.ijcard.2014.12.044

Cited by 26 publications

(34 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tei index, a systolic and diastolic function index, increased significantly under a mild RV pressure overload condition. This result is in line with previous studies in patients with borderline PH . In addition, similar to previous studies in patients with PH, Tei index was an independent predictor of PVR and CI.…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Changes in right ventricular function assessed by echocardiography in dog models of mild RV pressure overload

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 93%

“…This result is in line with previous studies in patients with borderline PH. 37 In addition, similar to previous studies in patients with PH, 16,34,38 Tei index was an independent predictor of PVR and CI. Furthermore, diastolic function, as assessed by Tau, was impaired in dog models of mild RV pressure overload.…”

Section: Discussionsupporting

confidence: 84%

Changes in right ventricular function assessed by echocardiography in dog models of mild RV pressure overload

et al. 2017

View full text Add to dashboard Cite

show abstract

“…It has been well documented that the global systolic left ventricular (LV) and right ventricular (RV) functions are well preserved, but both ventricles show altered filling patterns, subendocardial systolic dysfunction, and the increase in mean pulmonary arterial pressure (mPAP) [1][2][3]. Notably, there may be a potential association between altered cardiac functions and the incidence of acute mountain sickness [4], whereas the increase in mPAP may limit exercise capacity at HA [5,6]. Although the cardiac responses to HA exposure are of great significance, the detailed characterizations are largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Effects of baseline heart rate at sea level on cardiac responses to high-altitude exposure

Tian

Liu

Yang

et al. 2020

Int J Cardiovasc Imaging

Self Cite

View full text Add to dashboard Cite

High-altitude (HA) exposure has been widely considered as a cardiac stress, and associated with altered cardiac function. However, the characteristics of cardiac responses to HA exposure are unclear. In total, 240 healthy men were enrolled and ascended to 4100 m by bus within 7 days. Standard echocardiography and color tissue Doppler imaging were performed at sea level and at 4100 m. In all subjects, HA exposure increased HR [65 (59, 71) vs. 72 (63, 80) beats/min, p < 0.001] but decreased the stroke volume index (SVi) [35.5 (30.5, 42.3) vs. 32.9 (27.4, 39.5) ml/m 2 , p < 0.001], leading to an unchanged cardiac index (CI). Moreover, baseline HR was negatively correlated with HA exposure-induced changes in HR (r = − 0.410, p < 0.001) and CI (r = − 0.314, p < 0.001). Following HA exposure, subjects with lowest tertile of baseline HR showed an increased HR [56 (53, 58) vs. 65 (58, 73) beats/min, p < 0.001], left ventricular ejection fraction (LVEF) [61.7 (56.5, 68.0) vs. 66.1 (60.7, 71.5) %, p = 0.004] and mitral S′ velocity [5.8 ± 1.4 vs. 6.5 ± 1.9 cm/s, p = 0.040]. However, subjects with highest tertile of baseline HR showed an unchanged HR, LVEF and mitral S′ velocity, but a decreased E′ velocity [9.2 ± 2.0 vs. 8.4 ± 1.8 cm/s, p = 0.003]. Our findings indicate that baseline HR at sea level could determine cardiac responses to HA exposure; these responses were characterized by enhanced LV function in subjects with a low baseline HR and by reduced LV myocardial velocity in early diastole in subjects with a high baseline HR.

show abstract

“…

We have read the article "High altitude-induced borderline pulmonary hypertension impaired cardiorespiratory fitness in healthy young men" written by Yang et al with great interest [1]. Actually, the study is very detailed and designed.

…”

mentioning

confidence: 99%

“…They aimed to investigate and compare the acute and chronic effects of high-altitude on borderline pulmonary hypertension in healthy subjects. They concluded that the pulmonary vascular system was negatively affected from by high altitude in healthy young men and so, the decline of cardiorespiratory fitness was associated with impaired right ventricular function, which was correlated with the elevated mean pulmonary artery pressure [1]. Thanks to the authors for their contributions.…”

mentioning

confidence: 99%

High altitude may affect cardiac structure in smoking subjects

Öztürk¹,

Aparcı²,

Öztürk³

et al. 2015

International Journal of Cardiology

View full text Add to dashboard Cite

High altitude-induced borderline pulmonary hypertension impaired cardiorespiratory fitness in healthy young men

Cited by 26 publications

References 30 publications

Changes in right ventricular function assessed by echocardiography in dog models of mild RV pressure overload

Changes in right ventricular function assessed by echocardiography in dog models of mild RV pressure overload

Effects of baseline heart rate at sea level on cardiac responses to high-altitude exposure

High altitude may affect cardiac structure in smoking subjects

Contact Info

Product

Resources

About