High-altitude exposure decreases bone mineral density and its relationship with gut microbiota: Results from the China multi-ethnic cohort (CMEC) study

Zuo, Haojiang; Zheng, Tianli; Wu, Ke; Yang, Tingting; Wang, Lingyao; Nima, Qucuo; Bai, Hua; Fan, Ziwei; Huang, Shourui; Luo, Ruocheng; Wu, Jiali; Zhou, Junmin; Xu, Huan; Zhang, Yingcong; Feng, Shiyu; Zeng, Peibin; Xiao, Xiong; Guo, Bing; Wei, Yonglan; Pei, Xiaofang; Zhao, Xing

doi:10.1016/j.envres.2022.114206

Cited by 13 publications

(10 citation statements)

References 61 publications

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“…Second, we isolated 14 strains, while the previous study isolated four strains (Du et al, 2018). Because environmental conditions can affect bacteria community and induce mutations in Salmonella (Baert et al, 2021; Zuo et al, 2022), which potentially causes rapid changes to antimicrobial resistance patterns (Peruzy et al, 2020), variation in AST results might stem from distinct antibiotic pressures or host environmental diversity (Yin et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Phenotypic and genotypic characterization of salmonella Enteritidis isolated from two consecutive Food‐Poisoning outbreaks in Sichuan, China

Ximei

Chen

Yang

et al. 2022

Journal of Food Safety

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Salmonella enterica serotype Enteritidis (SE) is a primary pathogen that causes foodborne diseases in humans. Although whole‐genome sequencing (WGS) ‐based typing analyses have been increasingly used to investigate food‐poisoning outbreaks, they are rarely applied to the epidemiology of multiple Salmonella outbreaks in Sichuan, China. This study therefore isolated SE from patients and food of two consecutive food‐poisoning outbreaks during 2020 in Sichuan, China. We tracked outbreak origin using epidemiological investigation, serotyping, antimicrobial susceptibility testing (AST), pulsed‐field gel electrophoresis (PFGE), and WGS. We also determined phylogenetic relationships using PFGE, whole and core genome multilocus sequence typing (wg/cgMLST), and whole‐genome single nucleotide polymorphism (wgSNP) analyses. Epidemiological investigations identified a correlation between cake consumption and food poisoning. Thirteen strains isolated from patients and one strain isolated from the cake were confirmed as SE. Among the 14 strains, only six shared the same AST pattern (AMP‐AMS‐Sul‐STR). Isolates from patients and cakes were indistinguishable in PFGE results. All four methods, namely PFGE, wgMLST, cgMLST, and wgSNP were appropriate for bacterial typing in SE‐related outbreak investigation. However, wgSNP can assign 12 SE strains from the first outbreak to one cluster and assign two SE strains from the second outbreak to another cluster, while PFGE, wgMLST, cgMLST did not successfully distinguish the SE strains from different outbreaks. Thus, we conclude that SNP‐based phylogenetic analysis might be a viable method for differentiating SE strains at the outbreak level.

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Section: Discussionmentioning

confidence: 99%

Phenotypic and genotypic characterization of salmonella Enteritidis isolated from two consecutive Food‐Poisoning outbreaks in Sichuan, China

Ximei

Chen

Yang

et al. 2022

Journal of Food Safety

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“…High-altitude environments may also affect bone density. A multicenter study conducted in China found a negative correlation between altitude and quantitative ultrasound index (QUI) of bones, with Streptococcus playing a significant mediating role, suggesting that high-altitude exposure may reduce adult bone density, thereby increasing the risk of osteoporosis, with potential involvement of the intestinal microbiota ( Zuo et al, 2022 ).…”

Section: Impact Of Intestinal Microbiota Alterations On Organismal He...mentioning

confidence: 99%

“…Factors such as hypobaric hypoxia, low temperatures, and high radiation not only impact organismal reproduction and survival but also accelerate population-level evolution and physiological adaptations ( Hu et al, 2022 ). These conditions may also precipitate high-altitude reactions or illnesses in susceptible individuals, potentially leading to dysbiosis in the intestinal microbiota ( Lan et al, 2017 ; Zuo et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the intestinal microbiota acts as a critical regulatory factor in response to high-altitude environments, influencing the adaptive processes of the body ( Zhao et al, 2022 ; Zuo et al, 2022 ). Various enzymes, metabolic products, and signaling molecules produced by the intestinal microbiota may modulate the response of the body to high-altitude conditions through intricate signaling pathways.…”

Section: Introductionmentioning

confidence: 99%

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High-altitude-induced alterations in intestinal microbiota

Liu,

Chen,

Xiao

et al. 2024

Front. Microbiol.

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In high-altitude environments characterized by low pressure and oxygen levels, the intestinal microbiota undergoes significant alterations. Whether individuals are subjected to prolonged exposure or acute altitude changes, these conditions lead to shifts in both the diversity and abundance of intestinal microbiota and changes in their composition. While these alterations represent adaptations to high-altitude conditions, they may also pose health risks through certain mechanisms. Changes in the intestinal microbiota induced by high altitudes can compromise the integrity of the intestinal mucosal barrier, resulting in gastrointestinal dysfunction and an increased susceptibility to acute mountain sickness (AMS). Moreover, alterations in the intestinal microbiota have been implicated in the induction or exacerbation of chronic heart failure. Targeted modulation of the intestinal microbiota holds promise in mitigating high-altitude-related cardiac damage. Dietary interventions, such as adopting a high-carbohydrate, high-fiber, low-protein, and low-fat diet, can help regulate the effects of intestinal microbiota and their metabolic byproducts on intestinal health. Additionally, supplementation with probiotics, either through dietary sources or medications, offers a means of modulating the composition of the intestinal microbiota. These interventions may offer beneficial effects in preventing and alleviating AMS following acute exposure to high altitudes.

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“…Future studies should focus on the comparison of different samples, e.g., saliva vs. tissue. In addition, geographic, race and diet differences may be the other factors for the conflicting findings [18,36,37]. For instance, patients in Aykut' s study were enrolled from the NYU Langone Medical Center, New York, United States, where Caucasians are the main race [3].…”

Section: Logistic Regression For Mycobiota Profilementioning

confidence: 99%

Oral mycobiota and pancreatic ductal adenocarcinoma

et al. 2022

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Early detection of pancreatic ductal adenocarcinoma (PDAC) is essential for survival. Preliminary research demonstrated significant associations between structural alternation of mycobiota and PDAC. In this study, we investigated the associations between oral mycobiota and PDAC. We further explored mycobiota biomarkers for PDAC detection. We enrolled 34 PDAC patients and 35 matched healthy controls from West China hospital in Southwest China. Demographic data, clinical information, and salivary samples were collected. Mycobiota characteristics were defined using Internal Transcribed Spacer (ITS) ribosomal RNA sequencing. We found that the PDAC patients had significant increase in fungal abundance (P < 0.001) and significant decrease in fungal diversity (P < 0.001) in comparison to the healthy controls. A higher abundance of Basidiomycota and Unclassifed_p_Ascomycota was associated with an increased risk of PDAC. With each increase of abundance of g__unclassified_k__Fungi and g__unclassified_p__Ascomycota in PDAC patients, the risk of pancreatic cancer increased by 1.359 odds and 1.260 odds, respectively. Aspergillus (AUC = 0.983, 95% CI 0.951–1.000) and Cladosporium (AUC = 0.969, 95% CI 0.921–1.000) achieved high classification powers to distinguish PDAC patients from the healthy controls. The rapid, inexpensive tests of ITS1 sequencing of mycobiota and PCR detection of potential fungal biomarkers make it promising for the clinical practice to use oral microbes for PDAC early detection and prevention. Results of our study provide evidence that salivary mycobiota may provide insights into cancer risk, prevention, and detection.

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High-altitude exposure decreases bone mineral density and its relationship with gut microbiota: Results from the China multi-ethnic cohort (CMEC) study

Cited by 13 publications

References 61 publications

Phenotypic and genotypic characterization of salmonella Enteritidis isolated from two consecutive Food‐Poisoning outbreaks in Sichuan, China

Phenotypic and genotypic characterization of salmonella Enteritidis isolated from two consecutive Food‐Poisoning outbreaks in Sichuan, China

High-altitude-induced alterations in intestinal microbiota

Oral mycobiota and pancreatic ductal adenocarcinoma

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