High altitude and oxidative stress

Functional modulation of mitochondrial cytochrome c oxidase underlies adaptation to high-altitude hypoxia in a Tibetan migratory locust

“…The limited oxygen supply in hypoxia can shift the redox status of the respiratory chain towards a more-reduced status that increases mitochondrial ROS generation [30]. Thus, high-altitude animals can reduce ROS production by decreasing the reduced status of the respiratory chain [15].…”

“…This detergent treatment did not significantly affect the active core centre of COX (Z. Zhang and L. Kang 2012, unpublished data). The COX activities in SMPs were detected using a series of ferrocytochrome c starting concentrations (5,10,20,30,45, 65, 90 and 135 mM) to determine the ferrocytochrome c kinetics of COX. The Michaelis constant (K m ) and the maximal enzymatic activity (V max ) were then calculated by fitting the leastsquares Michaelis-Menten regressions to the data.…”

Low 8-oxo-7,8-dihydro-2′-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic

“…Populations living in the Andes have been exposed to As through drinking water for thousands of years and live at a high altitude, which is associated with increased oxidative stress [46,47]. However, this rural environment is also lacking a number of factors associated with oxidative stress; e.g.…”

Effects of High Altitude Related Oxidative Stress on Intraocular Pressure and Central Corneal Thickness – A Research Model for the Etiology of Glaucoma

“…During heavy physical exercise such as mountaineering, different organ damage can occur as a result of oxidative challenge. High altitude exposure leads to altered activity of reactive oxygen species, which in turn leads to oxidative damage (Dosek et al, 2007). When the human body is exposed to very low oxygen partial pressure (6,000m), cells tend to generate ATP.…”

“…Despite our limited knowledge on acute mountain sickness, current information suggests that reactive oxygen species are active players in the process, however it is still not clear whether they are causative or associative agents. At high altitude, UV radiation is significantly increased and this also contributes to the overproduction of reactive oxygen species (Baconyi and Radák, 2004;Dosek et al, 2007). It was found that 6 months of intermittent 4000 m exposure decreased mitochondrial superoxide dismutase in rat skeletal muscles (Radak et al, 1994).…”