High-altitude alpine therapy and lung function in asthma: systematic review and meta-analysis

Vinnikov, Denis; Khafagy, Abdullah A; Blanc, Paul D.; Brimkulov, Nurlan; Steinmaus, Craig

doi:10.1183/23120541.00097-2015

Cited by 33 publications

(34 citation statements)

References 37 publications

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“…Finally, there are also a large number of works that focus on the study of lung function at high altitudes and under conditions of physical exercise, 114 with special attention to the alterations in the diffusion capacity 115 and the influence on the maximal oxygen consumption(VO2 max) 116,117 . High‐altitude therapy for patients suffering from some type of respiratory complication, such as asthma, has also been shown to significantly improve lung function 118 …”

Section: Resultsmentioning

confidence: 99%

Effects of genetics and altitude on lung function

Talaminos-Barroso

Roa-Romero

Ortega-Ruiz

et al. 2020

Clinical Respiratory J

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Objectives The aim of this work is to present a review on the impact of genetics and altitude on lung function from classic and recent studies. Data source A systematic search has been carried out in different databases of scientific studies, using keywords related to lung volumes, spirometry, altitude and genetics. Results The results of this work have been structured into three parts. First, the relationship between genes and lung function. Next, a review of the genetic predispositions related to respiratory adaptation of people who inhabit high‐altitude regions for millennia. Finally, temporary effects and long‐term acclimatisation on respiratory physiology at high altitude are presented. Conclusions The works focused on the influence of genetics and altitude on lung function are currently of interest in terms of studying the interactions between genetic, epigenetic and environmental factors in the configuration of the pathophysiological adaptation patterns.

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Section: Resultsmentioning

confidence: 99%

Effects of genetics and altitude on lung function

Talaminos-Barroso

Roa-Romero

Ortega-Ruiz

et al. 2020

Clinical Respiratory J

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“…There is conflicting evidence regarding the benefits of climate therapy in the mountains for children with asthma [1][2][3][4][5][6], whereas higher evidence of effectiveness is available for adults with refractory asthma [1]. Allergen sensitization, airway eosinophilia, type 2 inflammation and outdoor air pollution are recognized triggers of asthma at school-age [7].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Climate Therapy on Cardiorespiratory Fitness and Exercise-Induced Bronchoconstriction in Children with Asthma

et al. 2021

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We investigated whether a 1-week stay in the mountains may have a positive impact on Exercise-Induced Bronchoconstriction (EIB) and cardiorespiratory endurance in asthmatic children from an urban area. Spirometry was performed before and 10 min after a 20 m shuttle run test (20mSRT) on the first and seventh day of a summer asthma camp in the Italian Alps at 900 m of altitude. Spirometry z-scores were derived from the Global Lung Initiative 2012 prediction equations, and percentiles of the 20mSRT performance were assigned according to De Miguel-Etayo’s and Tomkinson’s predictive equations. A FEV1 decrease ≥10% after the exercise was defined as EIB. Particulate matter pollution was monitored during the camp and in the urban area of provenience. Twenty-four subjects (age range 7–16 years) were included. Frequency of EIB decreased from 58% (14/24) at day-1 to 33% (8/24) at the end of the camp (p = 0.08). Most subjects with a 20mSRT in the lowest quartile at day 1 had EIB (9/11). The proportion of children with a 20mSRT <25° percentile decreased from 45% (11/24) at day-1 to 16% (4/24) at day-7 (p = 0.02). Conclusion: One-week climate therapy in the mountains improved both bronchial hyperreactivity and cardiorespiratory endurance in our cohort of asthmatic children.

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“…The standard therapy of allergic respiratory disease is mainly focused on pharmacological interventions, allergen avoidance or specific immunotherapy [ 5 , 6 ]. Beside these approaches, regular physical activities or sojourns at high altitude have been shown to improve respiratory symptoms, quality of life and exercise capacity [ 7 , 8 ]. Furthermore, recreational outdoor winter exercise improves allergic airway inflammation, measured as fractional exhaled nitric oxide, and allergic symptoms, as our working group could recently show [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Winter Exercise and Speleotherapy for Allergy and Asthma: A Randomized Controlled Clinical Trial

Freidl¹,

Huber²,

Braunschmid³

et al. 2020

JCM

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(1) Background: The prevalence of allergic respiratory diseases is still rising and efforts towards holistic treatments should be made. Although speleotherapy is widely applied in Europe to treat chronic airway diseases, the existing scientific evidence is rather low. Recreational winter exercise has been shown to improve allergic airway inflammation, but little is known about the combined effects of speleotherapy and recreational winter exercise. (2) Methods: In this clinical study we investigated the effects of winter exercise and speleotherapy on adults with allergic rhinitis and/or asthma. The speleotherapy group (n = 23) participated in a ten-day combined winter exercise and speleotherapy program and the exercise group (n = 18) joined a full-day winter sports program. The effects on allergic airway inflammation, quality of life, spirometry and cardiorespiratory fitness were assessed. (3) Results: No significant effects were found for fractional exhaled nitric oxide or nasal nitric oxide. Quality of life (p < 0.001 time effect) and allergic symptoms (p < 0.001 time effect) were improved in the speleotherapy and in the exercise group. (4) Conclusions: Winter exercise alone and winter exercise in combination with speleotherapy improve quality of life and allergic symptoms in adults with allergic rhinitis and/or asthma. Further studies are required to investigate the specific effects of speleotherapy. To our knowledge, this is the first investigation examining speleotherapy in combination with winter exercise. Recreational outdoor winter exercise and speleotherapy may be recommended for highly functioning patients with good disease control.

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High-altitude alpine therapy and lung function in asthma: systematic review and meta-analysis

Cited by 33 publications

References 37 publications

Effects of genetics and altitude on lung function

Effects of genetics and altitude on lung function

The Effects of Climate Therapy on Cardiorespiratory Fitness and Exercise-Induced Bronchoconstriction in Children with Asthma

Winter Exercise and Speleotherapy for Allergy and Asthma: A Randomized Controlled Clinical Trial

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