High alcohol intake as a risk and prognostic factor for community-acquired pneumonia

Fernández-Solà, J

doi:10.1001/archinte.155.15.1649

Cited by 88 publications

(90 citation statements)

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“…The effects of alcohol consumption are also equivocal: one study reports chronic alcoholism increases pneumonia mortality risk, 31 while a significant relationship between drinking habits and pneumonia infection was excluded in another. 27 Our results from multivariate analyses showed ex-drinkers were associated with increased pneumonia mortality risk, while current-drinkers and even heavy-drinkers were not significantly associated with mortality risk.…”

Section: Multivariate Analyses Of Possible Risk and Protective Factorsmentioning

confidence: 99%

Risk and Protective Factors Related to Mortality from Pneumonia among Middleaged and Elderly Community Residents: The JACC Study

Inoue

Koizumi

Wada

et al. 2007

Journal of Epidemiology

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Section: Multivariate Analyses Of Possible Risk and Protective Factorsmentioning

confidence: 99%

Risk and Protective Factors Related to Mortality from Pneumonia among Middleaged and Elderly Community Residents: The JACC Study

Inoue

Koizumi

Wada

et al. 2007

Journal of Epidemiology

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“…In a case-control study of patients with community-acquired pneumonia, alcohol intake was identified as a risk factor. High-alcohol intake patients showed a higher incidence of pneumonia and more severe clinical symptoms than patients with a low alcohol intake (Fernandez-Sola et al, 1995). ETOH in vitro suppresses significantly the production of pro-inflammatory cytokines such as tumor necrosis factor-a (TNFa) by human peripheral blood mononuclear cells (PBMCs) Szabo et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Daily moderate amounts of red wine or alcohol have no effect on the immune system of healthy men

et al. 2003

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Objective: To investigate whether the daily intake of red wine (RW) at a dose which inversely correlates with cardiovascular disease (CVD) risk modulates immune functions in healthy men. Design: Randomized single-blind trial with four intervention periods. Setting: The Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Karlsruhe, Germany. Subjects: A total of 24 healthy males with moderate alcohol consumption patterns were recruited and all completed the study. Intervention: Participants consumed 500 ml of RW (12% ethanol (ETOH)) or 500 ml of a 12% ETOH dilution per day for a period of 2 weeks. To control the potential effects of RW polyphenols, accordingly 500 ml/day of dealcoholized red wine (DRW) and of red grape juice (RGJ) were given. The following immune parameters were measured before beverage consumption and at 1 and 2 weeks following beverage consumption: phagocytic activity of neutrophils and monocytes, production of tumor necrosis factor-alpha (TNFa), interleukin-2 and -4, transforming growth factor-b, TNFa mRNA, lymphocyte proliferation, lytic activity of natural killer cells, and percentage of apoptotic lymphocytes. Results: Consumption of a moderate volume of alcohol with RW and with a 12% ETOH dilution had no effect on immune functions in healthy males. Consumption of polyphenol-rich beverages (DRW and RGJ) did not affect immunity-related parameters. Conclusions: Daily moderate consumption of alcohol and of RW for 2 weeks at doses which inversely correlate with CVD risk has no adverse effects on human immune cell functions. Polyphenol-rich beverages such as RGJ and DRW further do not suppress immune responses in healthy men.

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“…More recently, in 1995, a case-controlled study in Spain of 50 control subjects and 50 patients with community-acquired pneumonia identified high alcohol intake as a risk factor for pneumonia (5).…”

mentioning

confidence: 99%

Acute Alcohol Inhibits TNF-α Processing in Human Monocytes by Inhibiting TNF/TNF-α-Converting Enzyme Interactions in the Cell Membrane

Zhao

Marrero

Song

et al. 2003

The Journal of Immunology

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Alcohol abuse has long been known to adversely affect innate immune responses and predispose to infections. One cellular mechanism responsible for this effect is alcohol-induced suppression of TNF-α by mononuclear phagocytes. We undertook experiments to better understand the cellular mechanisms by which alcohol dose-dependently suppresses TNF elaboration by human monocytes. Here we show in human primary monocytes and cell lines that alcohol suppresses LPS-induced TNF secretion post-transcriptionally by inhibiting cellular processing by TNF-α-converting enzyme (TACE). Using fluorescent resonance energy transfer microscopy, physiological relevant levels of alcohol resulted in a reversible dose-dependent decrease in fluorescent resonance energy transfer efficiency between TNF and TACE. These data demonstrate that alcohol inhibits interactions between TNF and its converting enzyme, TACE, possibly by affecting membrane fluidity. These data in part explain the cellular mechanisms by which alcohol impairs monocyte function and may identify immunotherapeutic targets aimed at restoring immune function in this at-risk patient population.

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High alcohol intake as a risk and prognostic factor for community-acquired pneumonia

Abstract: High alcohol intake is the main risk factor for developing community-acquired pneumonia in middle-aged people. This situation also confers a worse prognosis in these patients, who should be treated with broad-spectrum antibiotics for a longer period.

Cited by 88 publications

References 0 publications

Risk and Protective Factors Related to Mortality from Pneumonia among Middleaged and Elderly Community Residents: The JACC Study

Risk and Protective Factors Related to Mortality from Pneumonia among Middleaged and Elderly Community Residents: The JACC Study

Daily moderate amounts of red wine or alcohol have no effect on the immune system of healthy men

Acute Alcohol Inhibits TNF-α Processing in Human Monocytes by Inhibiting TNF/TNF-α-Converting Enzyme Interactions in the Cell Membrane

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