High accuracy proton relative stopping power measurement

Abbema, J.K. Van; Goethem, M. J. van; Mulder, J.; Biegun, A.; Greuter, Marcel J W; Schaaf, Arjen van der; Brandenburg, S.; Graaf, E.R. van der

doi:10.1016/j.nimb.2018.09.015

Cited by 9 publications

(7 citation statements)

References 37 publications

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“…The resulting RSP was 1.025 ± 0.001 (mean and one standard deviation testing three gel batches) respectively. According to van Abbema et al 26 . the uncertainty in the determination of the RSP based on length and range measurement is below 0.4%.…”

Section: Methodsmentioning

confidence: 99%

Measurement‐based range evaluation for quality assurance of CBCT‐based dose calculations in adaptive proton therapy

Neppl

Kurz

Köpl³

et al. 2021

Medical Physics

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In online adaptive radiation therapy, in-room CBCT imaging data lacks the quality and accurate electron density information a planning X-ray computed tomography (CT) scan provides. Therefore, corrections of the in-room images must be performed to enable dose calculation and treatment adaptation. These procedures need to be Accepted ArticleThis article is protected by copyright. All rights reserved evaluated carefully. So far, evaluations are only based on recalculation of the initial treatment plan on the new image data and disregard effects of the optimization itself.This study aims to fill this gap by proposing a measurement and reoptimization based approach to analyze image data for online adaptive proton therapy, where inaccuracies in the planning image data have a much larger effect on dose calculation and optimization compared to photon therapy.The measured results of this study showed a high agreement with the expectations from recalculations and reoptimization based on the treatment planning system only.

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Section: Methodsmentioning

confidence: 99%

Measurement‐based range evaluation for quality assurance of CBCT‐based dose calculations in adaptive proton therapy

Neppl

Kurz

Köpl³

et al. 2021

Medical Physics

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“…The current radiation physics research by both internal and external users focuses on near-real-time in vivo range verification in particle therapy [93,94] and various aspects of dosimetry, including characterization of the LET distribution of particle beams [95] and tissue relative stopping powers [96].…”

Section: Kvi-cartmentioning

confidence: 99%

Biomedical Research Programs at Present and Future High-Energy Particle Accelerators

et al. 2020

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Biomedical applications at high-energy particle accelerators have always been an important section of the applied nuclear physics research. Several new facilities are now under constructions or undergoing major upgrades. While the main goal of these facilities is often basic research in nuclear physics, they acknowledge the importance of including biomedical research programs and of interacting with other medical accelerator facilities providing patient treatments. To harmonize the programs, avoid duplications, and foster collaboration and synergism, the International Biophysics Collaboration is providing a platform to several accelerator centers with interest in biomedical research. In this paper, we summarize the programs of various facilities in the running, upgrade, or construction phase.

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“…An energy-specific calibration curve was constructed for the imaging system to calculate the WET of any phantom being imaged. The calibration curve was plotted by stacking 8 plastic water slabs of known physical thicknesses (5,10,20,40,60,80, 100, and 110 mm) in front of the scintillator volume. The slabs were positioned in the x-y plane (see figure 1) such that their thicknesses were along the z-axis.…”

Section: Calibration Curvementioning

confidence: 99%

“…Other approaches such as a dual-energy CT technique for generating SPR distributions have been proposed as an alternative to the x-ray CT-based treatment planning methods (Yang et al 2010). Work on dual-energy CT method has been published using both phantoms (Bourque et al 2014, Hunemohr et al 2014, van Abbema et al 2018 as well as through clinical studies (Wohlfahrt et al 2017, Taasti andJensen 2018). Dualenergy CT is a promising technology with the potential to decrease proton range uncertainties.…”

Section: Introductionmentioning

confidence: 99%

A proton imaging system using a volumetric liquid scintillator: a preliminary study

Darne

Alsanea

Robertson

et al. 2019

Biomed. Phys. Eng. Express

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With the expansion of proton radiotherapy for cancer treatments, it has become important to explore proton-based imaging technologies to increase the accuracy of proton treatment planning, alignment, and verification. The purpose of this study is to demonstrate the feasibility of using a volumetric liquid scintillator to generate proton radiographs at a clinically relevant energy (180 MeV) using an integrating detector approach. The volumetric scintillator detector is capable of capturing a wide distribution of residual proton beam energies from a single beam irradiation. It has the potential to reduce acquisition time and imaging dose compared to other proton radiography methods. The imaging system design is comprised of a volumetric (20 × 20 × 20 cm 3 ) organic liquid scintillator working as a residual-range detector and a charge-coupled device (CCD) placed along the beams'-eye-view for capturing radiographic projections. The scintillation light produced within the scintillator volume in response to a 3-dimensional distribution of residual proton beam energies is captured by the CCD as a 2-dimensional grayscale image. A light intensity-to-water equivalent thickness (WET) curve provided WET values based on measured light intensities. The imaging properties of the system, including its contrast, signal-to-noise ratio, and spatial resolution (0.19 line-pairs/mm) were determined. WET values for selected Gammex phantom inserts including solid water, acrylic, and cortical bone were calculated from the radiographs with a relative accuracy of −0.82%, 0.91%, and −2.43%, respectively. Image blurring introduced by system optics was accounted for, resulting in sharper image features. Finally, the system's ability to reconstruct proton CT images from radiographic projections was demonstrated

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High accuracy proton relative stopping power measurement

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Cited by 9 publications

References 37 publications

Measurement‐based range evaluation for quality assurance of CBCT‐based dose calculations in adaptive proton therapy

Measurement‐based range evaluation for quality assurance of CBCT‐based dose calculations in adaptive proton therapy

Biomedical Research Programs at Present and Future High-Energy Particle Accelerators

A proton imaging system using a volumetric liquid scintillator: a preliminary study

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