In this article, a two-grid mixed finite element (TGMFE) method with some second-order time discrete schemes is developed for numerically solving nonlinear fourth-order reaction diffusion equation. The two-grid MFE method is used to approximate spatial direction, and some second-order θ schemes formulated at time t k−θ are considered to discretize the time direction. TGMFE method covers two main steps: a nonlinear MFE system based on the space coarse grid is solved by the iterative algorithm and a coarse solution is arrived at, then a linearized MFE system with fine grid is considered and a TGMFE solution is obtained. Here, the stability and a priori error estimates in L 2 -norm for both nonlinear Galerkin MFE system and TGMFE scheme are derived. Finally, some convergence results are computed for both nonlinear Galerkin MFE system and TGMFE scheme to verify our theoretical analysis, which show that the convergence rate of the time second-order θ scheme including Crank-Nicolson scheme and second-order backward difference scheme is close to 2, and that with the comparison to the computing time of nonlinear Galerkin MFE method, the CPU-time by using TGMFE method can be saved.