High Acceptability of Donating Hair and Other Biological Samples for Research Among People Living with HIV in an Outpatient Clinic in Lagos, Nigeria

Herbertson, Ebiere; Lahiri, Cecile D.; Nwogu, Jacinta N.; Soremekun, Rebecca; Olugbake, O.A.; Ezechi, Oliver; Gandhi, Monica

doi:10.1089/aid.2020.0214

Cited by 6 publications

(7 citation statements)

References 32 publications

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“…He found that in an ethnically diverse, urban-based Nigerian study population; nearly two-thirds of the participants were willing to donate hair samples for biomedical research. Our study findings on this theme are in agreement with the findings by Herbertson et al 17 and also the findings by Coetzee etal 12 The fourth theme we identified in our research was the perceived advantages and disadvantages of using hair as a routine hospital test for TB treatment adherence monitoring. Most of the interviewees expressed the advantages of using hair for routine hospital testing like it being easy to harvest, and not being painful like needle pricks would be for blood draws.…”

Section: Discussionsupporting

confidence: 92%

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Acceptability of hair harvest as a method of tuberculosis therapeutic drug monitoring among adult pulmonary TB patients: a qualitative study

Grace,

David.K,

Robert

et al. 2023

Afr H. Sci.

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Background: The current six months regimen for drug-susceptible tuberculosis (TB) is long, complex, and requires adherence monitoring. TB hair drug level assay is one innovative approach to monitor TB treatment adherence however, its acceptability in the context of African multi-cultural settings is not known.Objective: To determine the acceptability of hair harvest and testing as a TB therapeutic drug monitoring method.Methods: The study explored perceptions, and lived experiences among TB patients with regard to using hair harvest and testing as a method of tuberculosis therapeutic drug monitoring in the context of their cultural beliefs, and faith. We used a descriptive phenomenological approach.Results: Four main themes emerged namely: participants’ perceptions about the cultural meaning of their body parts; perceptions about hair having any medical value or meaning; perceptions about hospitals starting to use hair harvest and testing for routine hospital TB treatment adherence monitoring; and perceived advantages and disadvantages of using hair for treatment adherence monitoring. Overall, we found that using hair to monitor adherence was acceptable to TB patients provided the hair was harvested and tested by a medical worker.Conclusion: Hair harvest for medical testing is acceptable to TB patients on the condition that it is conducted by a medical worker.

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Section: Discussionsupporting

confidence: 92%

“…Herbertson et al . 17 studied patient willingness to donate hair for biomedical research. He found that in an ethnically diverse, urban-based Nigerian study population; nearly two-thirds of the participants were willing to donate hair samples for biomedical research.…”

Section: Discussionmentioning

confidence: 99%

Acceptability of hair harvest as a method of tuberculosis therapeutic drug monitoring among adult pulmonary TB patients: a qualitative study

Grace,

David.K,

Robert

et al. 2023

Afr H. Sci.

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“…Finally, hair is easy to collect, has no biohazardous precautions, can be stored at room temperature, and hair measurements can be performed in resource-constrained settings [ 8 ], providing some advantages over blood-based methods. While socio-cultural factors such as fear of rituals may limit the willingness of some Nigerians to accept hair sampling [ 37 ], acceptance is generally high [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of efavirenz levels in blood and hair with pharmacy refills as measures of adherence and predictors of viral suppression among people living with HIV in Nigeria

et al. 2022

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Background Strategies to support adherence are constrained by the lack of tools to objectively monitor medication intake in low-resource settings. Pharmacologic measures are objective, but pharmacy refill data is more accessible and cost-efficient. This study compared short-term and long-term efavirenz (EFV) drug levels with pharmacy refill adherence data (PRA) and evaluated their ability to predict viral suppression among people living with HIV in Nigeria. Methods Paired hair and dried blood spot (DBS) samples were obtained from 91 adults living with HIV receiving 600 mg EFV-based antiretroviral therapy (ART) and EFV concentrations were measured via validated methods using liquid-chromatography-mass-spectrometry. PRA was estimated from pharmacy records, based on the number of days a patient collected medication before or after the scheduled pick-up date. PRA was categorized into ≤ 74%, 75–94% and ≥ 95%, defined as poor, medium and high adherence, respectively. HIV viral loads closest to the hair sampling time (within 6 months) were also abstracted. Receiver Operating Characteristics (ROC) curve analyses compared the ability of adherence metrics to predict viral suppression. Results Based on PRA, 81% of participants had high adherence while 11% and 8% had medium and poor adherence, respectively. The median (IQR) EFV concentrations were 6.85 ng/mg (4.56–10.93) for hair and 1495.6 ng/ml (1050.7–2365.8) for DBS. Of the three measures of adherence, hair EFV concentration had the highest Area Under Curve (AUC) to predict viral suppression. Correlations between EFV concentrations in DBS and hair with PRA were positive (r = 0.12, P = 0.27 and r = 0.21, P = 0.05, respectively) but not strong. Conclusions EFV concentrations in hair were the strongest predictor of viral suppression and only weakly correlated with pharmacy refill adherence data in Nigeria. This study suggests that resource-limited settings may benefit from objective adherence metrics to monitor and support adherence.

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“… 30 , 31 A survey of people living with HIV found that respondents were 1.5 times more likely to donate hair rather than blood, urine, saliva or stool for research. 32 Additionally, hair samples provide scientific advantages in capturing concepts such as stress because they measure chronic physiological stress accumulated over periods of weeks and months, as compared to saliva‐, blood‐ or urine‐based measures, which provide momentary markers that are vulnerable to the effects of time‐of‐day and other within‐day fluctuations. 33 Nevertheless, it is imperative for researchers to understand the challenges associated with the acceptability and feasibility of hair sample collection.…”

Section: Introductionmentioning

confidence: 99%

“…Hair samples offer advantages over blood or saliva samples as they are relatively noninvasive, do not require medical professionals or a clinical environment and can be easily stored 30,31 . A survey of people living with HIV found that respondents were 1.5 times more likely to donate hair rather than blood, urine, saliva or stool for research 32 . Additionally, hair samples provide scientific advantages in capturing concepts such as stress because they measure chronic physiological stress accumulated over periods of weeks and months, as compared to saliva‐, blood‐ or urine‐based measures, which provide momentary markers that are vulnerable to the effects of time‐of‐day and other within‐day fluctuations 33 .…”

Section: Introductionmentioning

confidence: 99%

Recruitment and retention of adolescents for an ecological momentary assessment measurement burst mental health study: The MHIM engagement strategy

Murray,

Xie,

Power

et al. 2024

Health Expectations

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IntroductionRecruitment and long‐term retention of adolescent participants in longitudinal research are challenging and may be especially so in studies involving remote measurement and biosampling components. The ability to effectively recruit and retain participants can be supported by the use of specific evidence‐based engagement strategies that are built in from the earliest stages.MethodsInformed by a review of the evidence on effective engagement strategies and consultations with adolescents (via two Young Person Advisory Groups [YPAGs]; ages 11–13 and 14–17), the current protocol describes the planned participant engagement strategy for the Mental Health in the Moment Study: a multimodal measurement burst study of adolescent mental health across ages 11–19.ResultsThe protocol incorporates engagement strategies in four key domains: consultations/co‐design with the target population, incentives, relationship‐building and burden/barrier reduction. In addition to describing general engagement strategies in longitudinal studies, we also discuss specific concerns regarding engagement in data collection methods such as biosampling and ecological momentary assessment where a paucity of evidence exists.ConclusionEngagement strategies for adolescent mental health studies should be based on existing evidence and consultations with adolescents. We present our approach in developing the planned engagement strategies and also discuss limitations and future directions in engaging adolescents in longitudinal research.Patient or Public ContributionThe study design for this project places a strong emphasis on the active engagement of adolescents throughout its development. Specifically, the feedback and suggestions provided by the YPAGs have been instrumental in refining our strategies for maximising the recruitment and retention of participants.

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High Acceptability of Donating Hair and Other Biological Samples for Research Among People Living with HIV in an Outpatient Clinic in Lagos, Nigeria

Cited by 6 publications

References 32 publications

Acceptability of hair harvest as a method of tuberculosis therapeutic drug monitoring among adult pulmonary TB patients: a qualitative study

Acceptability of hair harvest as a method of tuberculosis therapeutic drug monitoring among adult pulmonary TB patients: a qualitative study

Comparison of efavirenz levels in blood and hair with pharmacy refills as measures of adherence and predictors of viral suppression among people living with HIV in Nigeria

Recruitment and retention of adolescents for an ecological momentary assessment measurement burst mental health study: The MHIM engagement strategy

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