Commentary on Dietze et al. (2010): Moving patient-centered health outcomes forwarda dd_3210 2149..2150 In their paper in this issue of Addiction, Dietze et al. reported the life satisfaction of injecting drug users compared to the general population [1]. Life satisfaction was measured using the Personal Wellbeing Index (PWI), which has seven satisfaction domains: standard of living, health, achievements in life, personal relationships, personal safety, feeling a part of the community and future security. All PWI domains were significantly lower in the injecting drug users than the general population. They also showed that increasing injection frequency and recent serious mental health problems predicted lower life satisfaction and being employed predicted higher life satisfaction across all domains. The authors suggested that results from this measure could inform more tailored treatment approaches for substance use disorder patients.A variety of life satisfaction (or subjective wellbeing) and health-related quality of life (HRQL) measures are available. For clarity, I will focus on the PWI for life satisfaction and preference-weighted HRQL measures (e.g. EuroQol, Health Utility Index, SF-6D, Quality of WellBeing, Assessment of Quality of Life). Recent evidence supports the construct validity of preference-weighted HRQL measures in SUD patients [2][3][4].There is a vigorous debate in the literature about the relative merits of subjective versus objective wellbeing for informing allocation of healthcare resources [5][6][7][8]. A major weakness cited for preference-weighted HRQL measures is that individuals assign preference weights to health states that they have not experienced, while a major weakness cited for life satisfaction measures is their strong association with personality traits, mood state, or both. An implication for life satisfaction measures informing health-care resource allocation decisions, and being correlated strongly with mood state is a greater proportion of health-care resources being allocated for mental health services. As a psychiatrist, perhaps this is not a major weakness after all.Whose perspective to use for assigning value to quality of life is also part of the debate. For the PWI, this issue is straightforward: the patient answers the question about their own life satisfaction on a 0-10 scale. A method for assigning relative weights to various health and nonhealth factors affecting life satisfaction has been suggested [5]. Aside from including non-health factors as covariates and using a continuum of death to full life satisfaction instead of death to perfect health, the suggested method resembles the one used to develop preference weights for the Quality of Well-Being (QWB) measure [9].For HRQL measures, the general public is recommended typically as the source of preference weights because general public resources pay for health care, the general public is blind to self-interest and outcome valuations should be representative of the entire at-risk population. Interestingly,...