High (20-Hz) and low (1-Hz) frequency transcranial magnetic stimulation as adjuvant treatment in medication-resistant depression

Garcı́a-Toro, Mauro; Salvà, Joan; Daumal, J.; Andres, Joana; Romera, Maria; Lafau, Oriol; Echevarría, M; Mestre, Martín; Bosch, Carmen; Collado, C. Tortajada; Ibarra, Olga; Aguirre, Iratxe

doi:10.1016/j.pscychresns.2004.08.005

Cited by 82 publications

(53 citation statements)

References 17 publications

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“…A few studies have shown that administration of low-frequency rTMS on the right dorsolateral prefrontal cortex is beneficial for improving the symptoms of PTSD 9 , by decreasing cortical excitability. Garcia-Toro et al 42 demonstrated that refractory PTSD patients showed an improvement of clinical symptoms after 10 sessions of low-frequency rTMS (1 Hz) applied to the right dorsolateral prefrontal cortex. In a complementary manner, Osuch et al 43 demonstrated that patients who had 20 sessions of low-frequency rTMS (1 Hz) on the right dorsolateral prefrontal cortex and PTSD exposure therapy showed a reduction in the symptomatic and psychophysiological effects of PTSD, as assessed by the Hamilton Depression Rating Scale, the Impact of Events Scale and the Clinical Administered PTSD Scale.…”

Section: Neuromodulation and Post-traumatic Stress Disordermentioning

confidence: 99%

Transcranial magnetic stimulation and transcranial direct current stimulation appear to be safe neuromodulatory techniques useful in the treatment of anxiety disorders and other neuropsychiatric disorders

Iannone

Cruz

Brasil‐Neto

et al. 2016

Arq. Neuro-Psiquiatr.

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Transcranial magnetic stimulation (TMS) has recently been investigated as a possible adjuvant treatment for many neuropsychiatric disorders, and has already been approved for the treatment of drug-resistant depression in the United States and in Brazil, among other countries. Although its use in other neuropsychiatric disorders is still largely experimental, many physicians have been using it as an off-label add-on therapy for various disorders. More recently, another technique, transcranial direct current stimulation (tDCS), has also become available as a much cheaper and portable alternative to TMS, although its mechanisms of action are different from those of TMS. The use of off-label therapeutic TMS or tDCS tends to occur in the setting of diseases that are notoriously resistant to other treatment modalities. Here we discuss the case of anxiety disorders, namely panic and post-traumatic stress disorders, highlighting the uncertainties and potential problems and benefits of the clinical use of these neuromodulatory techniques at the current stage of knowledge.

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Section: Neuromodulation and Post-traumatic Stress Disordermentioning

confidence: 99%

Transcranial magnetic stimulation and transcranial direct current stimulation appear to be safe neuromodulatory techniques useful in the treatment of anxiety disorders and other neuropsychiatric disorders

Iannone

Cruz

Brasil‐Neto

et al. 2016

Arq. Neuro-Psiquiatr.

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“…Of the five RCTs on bilateral rTMS for MD included in the previous meta-analyses, four were selected for the present investigation (Loo et al 2003 ;Fitzgerald et al 2006a ;Garcia-Toro et al 2006 ;McDonald et al 2006). Also, we retrieved three RCTs on bilateral rTMS for MD from Medline, PsycINFO, EMBASE, CENTRAL, SCOPUS and PQDT, and they were all included in this study (Pallanti et al 2010 ;Blumberger et al 2012 ;Fitzgerald et al 2012).…”

Section: Literature Searchmentioning

confidence: 99%

A systematic review and meta-analysis on the efficacy and acceptability of bilateral repetitive transcranial magnetic stimulation (rTMS) for treating major depression

2012

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“…A total of 9 studies reported results up to 12 weeks after completion of TMS (weighted average: 4.33 weeks) [27,35,36,38,39,42,44,48,51] . Effect size was calculated, when comparing outcome immediately after completion of TMS, with outcome at the end of the follow-up period.…”

Section: Follow-up Datamentioning

confidence: 99%

Transcranial Magnetic Stimulation in the Management of Mood Disorders

Allan

Herrmann²,

Ebmeier³

2011

Neuropsychobiology

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Background: Many trials of transcranial magnetic stimulation (TMS) have used small samples and, therefore, lack power. Here we present an up-to-date meta-analysis of TMS in the treatment of depression. Methods: We searched Medline and Embase from 1996 until 2008 for randomized sham-controlled trials, with patients and investigators blinded to treatment, and outcome measured using a version of the Hamilton Depression Rating Scale (or similar). We identified 1,789 studies. Thirty-one were suitable for inclusion, with a cumulative sample of 815 active and 716 sham TMS courses. Results: We found a moderately sized effect in favour of TMS [Random Effects Model Hedges’ g = 0.64, 95% confidence interval (95% CI) = 0.50–0.79]. The corresponding Pooled Peto Odds Ratio for treatment response (≤50% reduction in depression scores) was 4.1 (95% CI = 2.9–5.9). There was significant variability between study effect sizes. Meta-regressions with relevant study variables did not reveal any predictors of treatment efficacy. Nine studies included follow-up data with an average follow-up time of 4.3 weeks; there was no mean change in depression severity between the end of treatment and follow-up (Hedges’ g = –0.02, 95% CI = –0.22 to +0.18) and no heterogeneity in outcome. Discussion: TMS appears to be an effective treatment; however, at 4 weeks’ follow-up after TMS, there had been no further change in depression severity. Problems with finding a suitably blind and ineffective placebo condition may have confounded the published effect sizes. If the TMS effect is specific, only further large double-blind randomized controlled designs with systematic exploration of treatment and patient parameters will help to define optimum treatment indications and regimen.

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High (20-Hz) and low (1-Hz) frequency transcranial magnetic stimulation as adjuvant treatment in medication-resistant depression

Cited by 82 publications

References 17 publications

Transcranial magnetic stimulation and transcranial direct current stimulation appear to be safe neuromodulatory techniques useful in the treatment of anxiety disorders and other neuropsychiatric disorders

Transcranial magnetic stimulation and transcranial direct current stimulation appear to be safe neuromodulatory techniques useful in the treatment of anxiety disorders and other neuropsychiatric disorders

A systematic review and meta-analysis on the efficacy and acceptability of bilateral repetitive transcranial magnetic stimulation (rTMS) for treating major depression

Transcranial Magnetic Stimulation in the Management of Mood Disorders

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