HIF-3α mRNA expression changes in different tissues and their role in adaptation to intermittent hypoxia and physical exercise

Drevytska, T.; Gavenauskas, Bronislav; Drozdovska, Svitlana; Nosar, V. I.; Dosenko, Victor; Mankovskaya, I. N.

doi:10.1016/j.pathophys.2012.06.002

Cited by 32 publications

(25 citation statements)

References 13 publications

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“…The function of HIF-3α remains to be fully elucidated, however, it is an important factor for the fine-tuning of the hypoxic response in humans in physiological and pathological conditions (62,70). A previous study identified certain target genes of HIF-3α and confirmed its role as a transcription factor (19).…”

Section: Resultsmentioning

confidence: 94%

Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review)

Yang

Xiong

et al. 2015

Molecular Medicine Reports

106

103

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Abstract. Hypoxia inducible factors (HIFs) are transcription factors, which are commonly expressed in mammals, including humans. The HIFs consist of hypoxia-regulated α and oxygen-insensitive β subunits, and are key regulators of gene expression during hypoxia in normal and solid tumor tissues. Three members of the HIF family, HIF-1α, HIF-2α, and HIF-3α, are currently known. HIF-3α differs from HIF-1α and HIF-2α in protein structure and regulation of gene expression. For a long time, HIF-3α was considered as a negative mediator of HIF-regulated genes. HIF-3 has a transcriptional regulatory function, which negatively affects gene expression by competing with HIF-1α and HIF-2α in binding to transcriptional elements in target genes during hypoxia. Previously, certain target genes of HIF-3α have been identified, confirming the role of HIF-3α as a transcription factor. In this review, the protein structure, gene regulation and biological function of HIF-3 are discussed based on the literature.

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Section: Resultsmentioning

confidence: 94%

Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review)

Yang

Xiong

et al. 2015

Molecular Medicine Reports

106

103

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“…Repeated hypoxic exposure, comprising a slightly longer hypoxia/normoxia cycle, was shown to improve exercise performance in rodents. Normoxic exercise training in combination with short‐duration intermittent hypoxia at rest (5 cycles per day of 12% O 2 for 15 min and 20.9% O 2 for 15 min) for 2 weeks markedly improved the swimming time to exhaustion and maximal oxygen consumption in rats (Drevytska et al ). Running exercise under normoxia with short‐duration intermittent hypoxia (4 cycles per day of 12% O 2 for 15 min and 20.9% O 2 for 10 min) for 3 weeks markedly improved exercise performance by enhancing 3‐hydroxyacyl‐CoA‐dehydrogenase (HAD) activity and mRNA expression of PGC‐1 α in mice (Suzuki ).…”

Section: Introductionmentioning

confidence: 99%

Effects of exercise training with short‐duration intermittent hypoxia on endurance performance and muscle metabolism in well‐trained mice

Suzuki

2019

Physiol Rep

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The author previously reported that short‐duration intermittent hypoxia had additive effects on improvements in endurance capacity by enhancing fatty acid metabolism. The present study was designed to investigate the effects of short‐duration intermittent hypoxia on endurance capacity, metabolic enzyme activity, and protein levels associated with mitochondrial biogenesis in well‐trained mice. Mice in the training group were housed in a cage with a running wheel for 7 weeks from 5 weeks old. Voluntary running markedly increased maximal work values by 5.0‐fold. Trained mice were then subjected to either endurance treadmill training (ET) for 60 min or hybrid training (HT, ET for 30 min followed by sprint interval exercise (5‐sec run‐10‐sec rest) for 30 min) with (H‐ET or H‐HT) or without (ET or HT) short‐duration intermittent hypoxia (4 cycles of 12–13% O 2 for 15 min and 20.9% O 2 for 10 min) for 4 weeks. Maximal endurance capacity was markedly greater in the H‐ET and H‐HT than ET and HT groups, respectively. H‐ET and H‐HT increased activity levels of 3‐hydroxyacyl‐CoA‐dehydrogenase in oxidative muscle portion and pyruvate dehydrogenase complex in glycolytic muscle portion. These activity levels were significantly correlated with maximal endurance capacity. Protein levels of dynamin‐related protein‐1 were increased more by H‐ET and H‐HT than by ET and HT, but were not significantly correlated with maximal work. These results suggest that intermittent hypoxic exposure has beneficial effects on endurance and hybrid training to improve the endurance capacity via improving fatty acid and pyruvate oxidation in highly trained mice.

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“…О.О. Богомольця НАН України на підставі комплексного досліджен-ня розподілу в різних органах щурів матрич-ної РНК усіх субодиниць НIF за нормоксич-них та гіпоксичних умов отримано нові дані про зміни кількості мРНК HIF-1α, HIF-1β, HIF-2α і HIF-3α у різних органах [72][73][74][75]. За-стосування методу полімеразної ланцюгової реакції у реальному часі дало можливість уперше встановити значне підвищення рівня експресії мРНК субодиниці HIF-3α у серці, легенях і нирках щурів при ІГТ.…”

Section: вплив різних режимів інтервальної гіпоксії на оксигенацію ткunclassified

Mitochondria as a Target of Intermittent Hypoxia

Mankovskaya¹,

Serebrovska²

2014

Fiziol Zh

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HIF-3α mRNA expression changes in different tissues and their role in adaptation to intermittent hypoxia and physical exercise

Cited by 32 publications

References 13 publications

Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review)

Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review)

Effects of exercise training with short‐duration intermittent hypoxia on endurance performance and muscle metabolism in well‐trained mice

Mitochondria as a Target of Intermittent Hypoxia

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