Abstract:Background: Stabilization and increased activity of hypoxia-inducible factor 1-α (HIF-1α) could directly increase cancellous bone formation and was playing an essential role in bone modeling and remodeling. However, whether an increase of HIF-1α in ADSCs promoted osteogenic differentiation and bone formation was not known.
Results: In this study, ADSCs transfected with small interfering RNA and HIF-1α overexpression cDNA were established to investigate the proliferation, migration, adhesion, and osteogenic cap… Show more
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