HIF-1α or HOTTIP/CTCF Promotes Head and Neck Squamous Cell Carcinoma Progression and Drug Resistance by Targeting HOXA9

Sun, Qiang; Zhang, Shuai-Yuan; Jun, Zhao; Han, Xinguang; Wang, Haibin; Sun, Minglei

doi:10.1016/j.omtn.2022.01.001

Cited by 7 publications

(9 citation statements)

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“…37 On the other hand, HOTTIP was noted to be unfavorably correlated with the clinical stage, tumor stage and distant metastasis 36 and was found to transcriptionally modulate HOXA9 expression by working in concert with CCCTC Binding Factor promoting HNSCC progression and drug resistance. 38 Aberrant HOXA10-AS expression in OSCC patients correlated positively with overall survival and tumor grade, and its silencing resulted in decreased cell proliferation. 39 The HOTAIR expression is positively correlated with the tumor size, clinical and prognosis of OSCC.…”

Section: Discussionmentioning

confidence: 99%

“…Further, it inhibited tumorigenesis in nude mice xenograft models in vivo by acting as an endogenous miRNA sponge with miR‐148a, regulating DLG Associated Protein 1 (DLGAP1) 37 . On the other hand, HOTTIP was noted to be unfavorably correlated with the clinical stage, tumor stage and distant metastasis 36 and was found to transcriptionally modulate HOXA9 expression by working in concert with CCCTC Binding Factor promoting HNSCC progression and drug resistance 38 . Aberrant HOXA10‐AS expression in OSCC patients correlated positively with overall survival and tumor grade, and its silencing resulted in decreased cell proliferation 39 …”

Section: Discussionmentioning

confidence: 99%

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The regulatory role of HOX interacting lncRNA in oral cancer—An in silico analysis

Basavarajappa

Padam

Chakrabarty

et al. 2022

J Oral Pathology Medicine

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Objectives: We aim to elucidate the interaction of long noncoding RNAs with HOX genes and their regulatory role and potential drug candidates in oral cancer. Materials and Methods:The interaction network was constructed using RNA Interactome and the RNA Interactome from the Sequencing Experiments database. The differential expression of HOX genes and HOX interacting lncRNAs was assessed using the TCGA-Head and Neck Squamous Cell Carcinoma oral cancer dataset using DESeq2 R-package. Further, the functional enrichment analysis was performed for the differentially expressed HOX genes and HOX-interacting lncRNAs using Gene Ontology, long noncoding RNA Set Enrichment Analysis, lncRNA ontology annotation extractor and repository (Lantern), and LncRNA Ontology tools. Drug-lncRNA interaction and the effect of drugs on lncRNA expression were assessed from the D-lnc tool.Results: A total of 78 unique interactions were identified between HOX and lncRNAs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The regulatory role of HOX interacting lncRNA in oral cancer—An in silico analysis

Basavarajappa

Padam

Chakrabarty

et al. 2022

J Oral Pathology Medicine

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“…HOXA9 as an oncogene upregulated in Head and neck squamous cell carcinoma (HNSCC) is also reported to be related with HIF-1a signaling pathway. HOXA9 knockdown suppressed cell malignant events in CAL-27 and KB cells, and HOXA9 as a downstream target was transcriptionally regulated by HIF-1a [ 45 ]. In addition, Xia et al found that miR-652 promoted HIF-1alpha signaling through inhibition of HOXA9 expression in uveal melanoma [ 46 ].…”

Section: Hif-1α Signaling Pathwaymentioning

confidence: 99%

Role of HOXA9 in solid tumors: mechanistic insights and therapeutic potential

et al. 2022

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HOXA9 functioning as a transcription factor is one of the members of HOX gene family, which governs multiple cellular activities by facilitating cellular signal transduction. In addition to be a driver in AML which has been widely studied, the role of HOXA9 in solid tumor progression has also received increasing attention in recent years, where the aberrant expression of HOXA9 is closely associated with the prognosis of patient. This review details the signaling pathways, binding partners, post-transcriptional regulation of HOXA9, and possible inhibitors of HOXA9 in solid tumors, which provides a reference basis for further study on the role of HOXA9 in solid tumors.

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“…The oncogenic role of upregulated HOTTIP was established in CAL‐27 and KB cells suggesting that HOTTIP and CTCF worked in concert to modulate HOXA9 expression in HNSCC cells. Silencing of HOTTIP/CTCF exerted tumor‐suppressive effects in HNSCC 31 . In another study, HOTTIP was found to be highly expressed in tongue squamous cell carcinoma (TSCC) and correlated with clinical stage and distant metastasis portending unfavorable prognosis.…”

Section: Introductionmentioning

confidence: 99%

In silico interaction of HOX cluster‐embedded microRNAs and long non‐coding RNAs in oral cancer

Padam

Basavarajappa

Shenoy

et al. 2021

J Oral Pathology Medicine

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HOX genes are members of the homeotic transcription factor family, organized into four paralogous clusters. HOX complexes are believed to have arisen by genome-wide duplications during evolution. In humans, there are about 200 homeobox genes of which 39 are HOX genes, which are segregated onto four chromosomes, HOXA -7p15, HOXB -17q21.2, HOXC -12q13, and HOXD -2q31 (Figure 1). 1,2 The protein product of the HOX gene is a transcription factor that contains a conserved homeodomain region. 2 The homeodomain consists of the helix-turn-helix protein motif responsible for sequence-specific DNA binding. HOX genes are the pivotal regulators of growth and development. They regulate events such as differentiation, metabolism, apoptosis, autophagy, and their deregulation leads to various disorders and diseases including cancer. 3

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HIF-1α or HOTTIP/CTCF Promotes Head and Neck Squamous Cell Carcinoma Progression and Drug Resistance by Targeting HOXA9

Cited by 7 publications

References 0 publications

The regulatory role of HOX interacting lncRNA in oral cancer—An in silico analysis

The regulatory role of HOX interacting lncRNA in oral cancer—An in silico analysis

Role of HOXA9 in solid tumors: mechanistic insights and therapeutic potential

In silico interaction of HOX cluster‐embedded microRNAs and long non‐coding RNAs in oral cancer

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