HIF-1α Negatively Regulates Irisin Expression Which Involves in Muscle Atrophy Induced by Hypoxia

Liu, Shiqiang; Fu, Pengyu; Ning, Kaiting; Wang, Rui; Bi, Yuanguo; Chen, Jiahui; Xu, Huiyun

doi:10.3390/ijms23020887

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…A high-altitude environment also undermines fat deposition by reducing abdominal fat and intramuscular lipids ( 33 ). Meanwhile, chronic hypoxia caused by high altitude accelerates the decomposition of skeletal muscle and inhibits protein synthesis, leading to the decline in SMM and TBW ( 34 ). In addition, long-term living in a hypoxic environment results in a decrease in bone turnover and BM ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Normative reference data for body composition in healthy indigenous populations on the Qinghai-Tibet Plateau

Li²,

Huang³

et al. 2022

Front. Public Health

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Body composition represents an important aspect of physical fitness and has received increasing attention in recent years. The present study was designed and conducted to provide reference values for age-, sex-, and altitude-specific body composition for healthy indigenous Tibetan adults living on the Qinghai-Tibet Plateau, which has not yet been studied. A cross-sectional survey was conducted among 2,356 healthy Tibetan adults (1,433 females and 923 males) living on the Qinghai-Tibet Plateau for generations. The body composition of the participants was measured by bioelectrical impedance analysis (BIA). The measurements included weight, basal metabolic rate (BMR), fat-free mass (FFM), skeletal muscle mass (SMM), protein mass (PM), bone mass (BM), fat mass (FM), percentage of body fat (PBF), subcutaneous fat mass (SFM), visceral fat mass (VFM), total body water (TBW), intracellular water (ICW), and extracellular water (ECW). Overall, males had greater FFM, SMM, PM, BM, and water mass, whereas females were high in fat mass. Participants from plains generally had higher body composition values, and PM, BM, FM and body water values decreased with increasing altitude, with the lowest values found in >4,000 m Shigatse. FFM, SMM, PM, and BM tended to decrease with increasing age, whereas fat mass and ECW tended to increase with increasing age. This study provides the first normative reference data of body composition for healthy indigenous individuals on the Qinghai-Tibet Plateau. These datasets are important for future research related to body composition. A considerable decrease in body composition values in > 4,000 m-altitude areas suggested that body composition cutoff values should be established by altitude. Age-, sex-, and altitude-specific alterations in body composition values also inform the prevention and amendment of abnormal body composition changes and resultant health complications.

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Section: Discussionmentioning

confidence: 99%

Normative reference data for body composition in healthy indigenous populations on the Qinghai-Tibet Plateau

Li²,

Huang³

et al. 2022

Front. Public Health

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“…It has been proven that aberrant interactions among skeletal muscle fibres and immune cells contribute to the atrophy of skeletal muscle and decreased muscle function [ 9 ]. Abnormal biological behaviours in the muscle fibre microenvironment, such as inflammation and hypoxia, have also been attributed to the aberrant expression of TFs [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of a novel immune-related transcriptional regulatory network in sarcopenia

Zhang,

Zhu,

Zhang

et al. 2023

BMC Geriatr

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Background Sarcopenia is highly prevalent in elderly individuals and has a significant adverse effect on their physical health and quality of life, but the mechanisms remain unclear. Studies have indicated that transcription factors (TFs) and the immune microenvironment play a vital role in skeletal muscle atrophy. Methods RNA-seq data of 40 muscle samples were downloaded from the GEO database. Then, differentially expressed genes (DEGs), TFs(DETFs), pathways(DEPs), and the expression of immune gene sets were identified with limma, edgeR, GO, KEGG, ORA, GSVA, and ssGSEA. Furthermore, the results above were integrated into coexpression analysis by Pearson correlation analysis (PCA). Significant coexpression patterns were used to construct the immune-related transcriptional regulatory network by Cytoscape and potential medicine targeting the network was screened by Connectivity Map. Finally, the regulatory mechanisms and RNA expression of DEGs and DETFs were identified by multiple online databases and RT‒qPCR. Results We screened 808 DEGs (log2 fold change (FC) > 1 or < − 1, p < 0.05), 4 DETFs (log2FC > 0.7 or < − 0.7, p < 0.05), 304 DEPs (enrichment scores (ES) > 1 or < − 1, p < 0.05), and 1208 differentially expressed immune genes sets (DEIGSs) (p < 0.01). Based on the results of PCA (correlation coefficient (CC) > 0.4 or < − 0.4, p < 0.01), we then structured an immune-related network with 4 DETFs, 9 final DEGs, 11 final DEPs, and 6 final DEIGSs. Combining the results of online databases and in vitro experiments, we found that PAX5-SERPINA5-PI3K/Akt (CC ≤ 0.444, p ≤ 0.004) was a potential transcriptional regulation axis, and B cells (R = 0.437, p = 0.005) may play a vital role in this signal transduction. Finally, the compound of trichostatin A (enrichment = -0.365, specificity = 0.4257, p < 0.0001) might be a potential medicine for sarcopenia based on the PubChem database and the result of the literature review. Conclusions We first identified immune-related transcriptional regulatory network with high-throughput RNA-seq data in sarcopenia. We hypothesized that PAX5-SERPIAN5-PI3K/Akt axis is a potential mechanism in sarcopenia and that B cells may play a vital role in this signal transduction. In addition, trichostatin A might be a potential medicine for sarcopenia.

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“…For example, the concentration of irisin in patients with sarcopenia and pre-sarcopenia was lower compared with that in non-sarcopenic participants ( 82 , 83 ). Exposure to an ambient hypoxic environment can cause skeletal muscle loss and atrophy, along with the low concentration of irisin in blood circulation both in humans ( 84 ) and mice ( 85 ), which could be one of the reasons of muscle atrophy induced by hypoxia ( 86 ). However, interestingly, knockdown of fndc5 in skeletal muscle still performed equal muscle mass, development, growth, regeneration, and strength compared with WT mice.…”

Section: Introductionmentioning

confidence: 99%

Role of irisin in physiology and pathology

et al. 2022

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Irisin, out-membrane part of fibronectin type III domain–containing 5 protein (FNDC5), was activated by Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) during physical exercise in skeletal muscle tissues. Most studies have reported that the concentration of irisin is highly associated with health status. For instance, the level of irisin is significantly lower in patients with obesity, osteoporosis/fractures, muscle atrophy, Alzheimer’s disease, and cardiovascular diseases (CVDs) but higher in patients with cancer. Irisin can bind to its receptor integrin αV/β5 to induce browning of white fat, maintain glucose stability, keep bone homeostasis, and alleviate cardiac injury. However, it is unclear whether it works by directly binding to its receptors to regulate muscle regeneration, promote neurogenesis, keep liver glucose homeostasis, and inhibit cancer development. Supplementation of recombinant irisin or exercise-activated irisin might be a successful strategy to fight obesity, osteoporosis, muscle atrophy, liver injury, and CVDs in one go. Here, we summarize the publications of FNDC5/irisin from PubMed/Medline, Scopus, and Web of Science until March 2022, and we review the role of FNDC5/irisin in physiology and pathology.

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HIF-1α Negatively Regulates Irisin Expression Which Involves in Muscle Atrophy Induced by Hypoxia

Cited by 4 publications

References 39 publications

Normative reference data for body composition in healthy indigenous populations on the Qinghai-Tibet Plateau

Normative reference data for body composition in healthy indigenous populations on the Qinghai-Tibet Plateau

Identification of a novel immune-related transcriptional regulatory network in sarcopenia

Role of irisin in physiology and pathology

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