HIF-1 inhibition reverses opacity in a rat model of galactose-induced cataract
Masaru Takashima,
Masaya Nagaya,
Yoshihiro Takamura
et al.
Abstract:Cataract is an eye disease, in which the lens becomes opaque, causing vision loss and blindness. The detailed mechanism of cataract development has not been characterized, and effective drug therapies remain unavailable. Here, we investigated the effects of Hypoxia-inducible factor 1 (HIF-1) inhibitors using an ex vivo model, in which rat lenses were cultured in galactose-containing medium to induce opacity formation. We found that treatment with the HIF-1 inhibitors 2-Methoxyestradiol (2ME2), YC-1, and Bavach… Show more
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