Hierarchy of Neural Organization in the Embryonic Spinal Cord: Granger-Causality Graph Analysis of In Vivo Calcium Imaging Data

Fallani, Fabrizio De Vico; Corazzol, Martina; Sternberg, Jenna R.; Wyart, Claire; Chávez, Mario

doi:10.1109/tnsre.2014.2341632

Cited by 24 publications

(44 citation statements)

References 52 publications

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“…This has been explored for smaller numbers of neurons through repeated presentations of sensory stimuli paired with electrophysiology 11 12 13 14 15 16 17 18 19 20 21 23 24 25 26 27 35 , and also at the population level, principally through calcium imaging 22 34 36 37 38 39 40 44 . With the rise in genetically-encoded calcium indicators, a number of groups have taken advantage of the zebrafish model system to show how synchronous activity in the tectum 34 38 44 45 , habenula 46 47 , midbrain 48 and spinal cord 49 50 51 is spatially organised, and how patterns of synchronous activity relate to sensory processing. A thorough understanding of the functional architecture of responsive ensembles, however, requires that activity in an entire population of neurons be tracked through numerous presentations of a single stimulus.…”

Section: Discussionmentioning

confidence: 99%

Characterisation of sensitivity and orientation tuning for visually responsive ensembles in the zebrafish tectum

Thompson

Scott

2016

Sci Rep

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Sensory coding relies on ensembles of co-active neurons, but these ensembles change from trial to trial of the same stimulus. This is due in part to wide variability in the responsiveness of neurons within these ensembles, with some neurons responding regularly to a stimulus while others respond inconsistently. The specific functional properties that cause neurons to respond more or less consistently have not been thoroughly explored. Here, we have examined neuronal ensembles in the zebrafish tectum responsive to repeated presentations of a visual stimulus, and have explored how these populations change when the orientation or brightness of the stimulus is altered. We found a continuum of response probabilities across the neurons in the visual ensembles, with the most responsive neurons focused toward the spatial centre of the ensemble. As the visual stimulus was made dimmer, these neurons remained active, suggesting higher overall responsiveness. However, these cells appeared to represent the most consistent end of a continuum, rather than a functionally distinct “core” of highly responsive neurons. Reliably responsive cells were broadly tuned to a range of stimulus orientations suggesting that, at least for this stimulus property, tight stimulus tuning was not responsible for their consistent responses.

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Section: Discussionmentioning

confidence: 99%

Characterisation of sensitivity and orientation tuning for visually responsive ensembles in the zebrafish tectum

Thompson

Scott

2016

Sci Rep

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“…To address this, we applied Granger-causality analysis, a method for determining if a time series of events predicts (or Granger-"causes") a second time series [39], [40]. It has been classically applied to neurophysiological recordings in both animals and humans [41], [42] to study the influence of one brain area or neuron upon another ( Figure 4A, and see Materials and Methods, Granger-causality from calcium fluorescence imaging data).…”

Section: Information Transfer In Visual Areas During Prey Observationmentioning

confidence: 99%

Experience, circuit dynamics, and forebrain recruitment in larval zebrafish prey capture

Oldfield

Grossrubatscher

Chávez

et al. 2020

eLife

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Experience strongly influences behavior, but little is known about how experience is encoded in the brain, and how changes in neural activity are implemented at a network level to improve performance. Here we investigate how differences in experience impact brain circuitry and behavior in larval zebrafish prey capture. We find that experience of live prey compared to inert food increases capture success by boosting capture initiation. To explore the underlying neural basis, we studied the effects of prior experience of live prey on behavior and brain activity. In response to live prey, animals with and without prior experience of live prey all show activity in visual areas (pretectum and optic tectum) and motor areas (cerebellum and hindbrain), with similar visual area retinotopic maps of prey position. However, prey-experienced animals more readily initiate capture in response to visual area activity and also have greater visually-evoked activity in two forebrain areas: the telencephalon and the habenula. Consistent with the contribution of the forebrain to prey capture, disruption of neurons in the habenula reduced prey capture performance in prey-experienced fish. Together, our results suggest that experience of prey strengthens prey-associated visual drive to the forebrain, and that this lowers the threshold for prey-associated visual activity to trigger activity in motor areas, thereby improving capture performance.

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“…Neural networks involved in visual activity, hunting behavior, and navigation have already been defined (Ahrens et al 2013;Muto et al 2013;Bianco and Engert 2015;Romano et al 2015). In vivo experiments combined with mathematical modeling are beginning to explain how neural circuits function (Stobb et al 2012;De Vico Fallani et al 2014;Freeman et al 2014;Portugues et al 2015). Thus, the zebrafish larva is emerging as a valuable model to link genes, neuronal networks, and behavior.…”

Section: Future Directionsmentioning

confidence: 99%

Learning to Fish with Genetics: A Primer on the Vertebrate ModelDanio rerio

et al. 2016

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In the last 30 years, the zebrafish has become a widely used model organism for research on vertebrate development and disease. Through a powerful combination of genetics and experimental embryology, significant inroads have been made into the regulation of embryonic axis formation, organogenesis, and the development of neural networks. Research with this model has also expanded into other areas, including the genetic regulation of aging, regeneration, and animal behavior. Zebrafish are a popular model because of the ease with which they can be maintained, their small size and low cost, the ability to obtain hundreds of embryos on a daily basis, and the accessibility, translucency, and rapidity of early developmental stages. This primer describes the swift progress of genetic approaches in zebrafish and highlights recent advances that have led to new insights into vertebrate biology.

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Hierarchy of Neural Organization in the Embryonic Spinal Cord: Granger-Causality Graph Analysis of In Vivo Calcium Imaging Data

Abstract: ABSTRACT

Cited by 24 publications

References 52 publications

Characterisation of sensitivity and orientation tuning for visually responsive ensembles in the zebrafish tectum

Characterisation of sensitivity and orientation tuning for visually responsive ensembles in the zebrafish tectum

Experience, circuit dynamics, and forebrain recruitment in larval zebrafish prey capture

Learning to Fish with Genetics: A Primer on the Vertebrate ModelDanio rerio

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