Hierarchical superparamagnetic metal–organic framework nanovectors as anti-inflammatory nanomedicines

Abstract

Among a plethora of drug nanocarriers, biocompatible nanoscale Metal Organic Frameworks (nanoMOFs) with large surface area and amphiphilic internal microenvironment have emerged as promising drug delivery platforms, mainly for cancer...

Current status and prospects of MIL-based MOF materials for biomedicine applications

“…The USPIO@MIL nanocarrier loaded with anti-tumor and anti-inflammatory drugs (doxorubicin and methotrexate) showed highly potent anti-inflammatory and antitumor activity. 47 Chemotherapy based on Fe-MOFs can also be combined with other treatment methods such as photothermal therapy and photodynamic therapy to achieve multimodal therapy and improve treatment efficacy. In the future, researchers will continue to develop more Fe-MOF materials for chemotherapy, with better control release performance, higher biocompatibility, stronger targeting, etc.…”

“…The USPIO@MIL nanocarrier loaded with anti-tumor and anti-inflammatory drugs (doxorubicin and methotrexate) showed highly potent anti-inflammatory and anti-tumor activity. 47…”

Design and fabrication of intracellular therapeutic cargo delivery systems based on nanomaterials: current status and future perspectives

“…182 Recently, Zhao et al designed a novel hybrid nano-object coupling MIL-100(Fe) and ultra-small superparamagnetic iron oxide, USPIO@MIL, exhibiting excellent anti-inflammatory efficacy and high anti-tumor activity. 183 In addition, the excellent relaxation properties of USPIO@MIL demonstrated its suitability as an effective contrast agent for MRI. The above indicated its great potential as a therapeutic diagnostic anti-inflammatory agent with integrated imaging and therapeutic functions.…”

Interfacing metal organic frameworks with polymers or carbon-based materials: from simple to hierarchical porous and nanostructured composites

“…3,4 Their highly ordered pore structures, large surface areas and chemical functionalities make these materials highly promising for a wide range of applications, including gas storage and separation, catalysis, sensing, energy storage and biomedicine among others. [5][6][7][8][9] However, MOFs still face certain limitations that greatly hinder their transfer and implementation in real industrial applications. A large number of MOFs exhibit limited chemical and thermal stability and thus a poor resistance to water.…”

“…It is worth noting that numerous composites were similarly prepared through the connement of a wide range of inorganic and biological nanoentities and such composites have found numerous applications in (bio)catalysis, biomedicine, (bio) sensing and so on. 5,9 As presented in the next section, polymers could also be encapsulated in the MOF pores while they were also integrated as part of the MOF framework.…”