Hierarchical shape-by-shape assembly of microparticles for micrometer-scale viral delivery of two different genes

Lee, Daewon; Lee, Amos Chungwon; Han, Sang-Sun; Bae, Hyung Jong; Song, Seo Woo; Jeong, Yunjin; Oh, Dong Yoon; Cho, Seongkyu; Kim, Junhoi; Park, Wook; Kwon, Sunghoon

doi:10.1063/1.5030597

Cited by 12 publications

(9 citation statements)

References 22 publications

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“…The particle size is more uniform, the drug encapsulation rate is high, and the activity is well maintained, which overcomes the shortcomings of the emulsification solvent evaporation technology [47]. Gas shearing technology is a reliable method to accurately control the preparation of symmetric or anisotropic particles with different numbers and different characteristic compartments, and it can also be used for cell culture [48][49][50]. In addition, in-situ formation technology has also been developed to prepare microparticles directly at the site of the disease [51].…”

Section: Preparation Methods Of Plga Micro/nanoparticlementioning

confidence: 99%

PLGA-based drug delivery system for combined therapy of cancer: research progress

et al. 2021

Mater. Res. Express

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In recent years, PLGA micro/nano particle drug delivery systems has been widely used in cancer treatment. According to the unique properties of PLGA, carriers of various structures are designed to keep the function of drugs or bioactive substances, ensure the effective load of molecules and improve the bioavailability of drugs in diseased parts. PLGA is one of the earliest and most commonly used biodegradable materials. It is often used for functional modification with other polymers (such as polyethylene glycol and chitosan) or other molecules (such as aptamers and ligands) to deliver various small molecule drugs (such as DOX and DTX) and bioactive macromolecules (such as proteins and nucleic acids) to improve targeting, controlled release and therapeutic properties. In this paper, the preparation methods, physical and chemical properties and medical applications of PLGA micro/nano particles are discussed. We focused on the recent research progress of the PLGA-based drug carrier system in tumor combination therapy.

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Section: Preparation Methods Of Plga Micro/nanoparticlementioning

confidence: 99%

PLGA-based drug delivery system for combined therapy of cancer: research progress

et al. 2021

Mater. Res. Express

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“…This way, they were able to perform localized multiplex gene delivery within a single cell sample without cross-reaction among different viral vectors. The technique was then improved by a shape-by-shape assembly-based gene delivery technique to further increase the delivery combinations [143] (Figure 11b). Phage display is a well-known high-throughput screening platform for selecting antibodies that bind to targeted antigens.…”

Section: Microorganism-laden Hydrogels For Protein and Antibiotic Dru...mentioning

confidence: 99%

Recent Advances in Polymer Additive Engineering for Diagnostic and Therapeutic Hydrogels

Bae

Kim

Kwon

2022

IJMS

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Hydrogels are hydrophilic polymer materials that provide a wide range of physicochemical properties as well as are highly biocompatible. Biomedical researchers are adapting these materials for the ever-increasing range of design options and potential applications in diagnostics and therapeutics. Along with innovative hydrogel polymer backbone developments, designing polymer additives for these backbones has been a major contributor to the field, especially for expanding the functionality spectrum of hydrogels. For the past decade, researchers invented numerous hydrogel functionalities that emerge from the rational incorporation of additives such as nucleic acids, proteins, cells, and inorganic nanomaterials. Cases of successful commercialization of such functional hydrogels are being reported, thus driving more translational research with hydrogels. Among the many hydrogels, here we reviewed recently reported functional hydrogels incorporated with polymer additives. We focused on those that have potential in translational medicine applications which range from diagnostic sensors as well as assay and drug screening to therapeutic actuators as well as drug delivery and implant. We discussed the growing trend of facile point-of-care diagnostics and integrated smart platforms. Additionally, special emphasis was given to emerging bioinformatics functionalities stemming from the information technology field, such as DNA data storage and anti-counterfeiting strategies. We anticipate that these translational purpose-driven polymer additive research studies will continue to advance the field of functional hydrogel engineering.

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“…For example, even if disks containing different data are stored together without organization to minimize the volume of storage, the indexing is preserved, and the data do not interfere with each other. Additionally, the micro-disks can be assembled onto a microwell 20,21 for index organization and imaging, increasing the accessibility (Fig. 2c).…”

Section: Main Textmentioning

confidence: 99%

DNA micro-disk for the management of DNA-based data storage with index and write-once-read-many (WORM) memory features

Choi

Bae

Lee

et al. 2020

Preprint

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DNA-based data storage has attracted attention because of its higher physical density of the data and longer retention time than those of conventional digital data storage 1-7 . However, previous DNA-based data storage lacked index features and the data quality of storage after a single access is not preserved, obstructing its industrial use. Here, we propose DNA micro-disks, quick response (QR)-coded micro-sized disks that harbour data-encoded DNA molecules for the efficient management of DNA-based data storage. We demonstrate the two major features that previous DNA-based data storage studies could not achieve. One feature is accessing data items efficiently by indexing the data-encoded DNA library. Another is achieving write-once-read-many (WORM) memory through the immobilization of DNA molecules on the disk and their enrichment through in situ DNA production. Through these features, the reliability of DNA-based data storage was increased by allowing multiple accession of data-encoded DNA without data loss.

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Hierarchical shape-by-shape assembly of microparticles for micrometer-scale viral delivery of two different genes

Cited by 12 publications

References 22 publications

PLGA-based drug delivery system for combined therapy of cancer: research progress

PLGA-based drug delivery system for combined therapy of cancer: research progress

Recent Advances in Polymer Additive Engineering for Diagnostic and Therapeutic Hydrogels

DNA micro-disk for the management of DNA-based data storage with index and write-once-read-many (WORM) memory features

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