Hierarchical self-assembly of aromatic peptide conjugates into supramolecular polymers: it takes two to tango

Coste, Maëva; Suárez‐Picado, Esteban; Ulrich, Sébastien

doi:10.1039/d1sc05589e

Cited by 12 publications

(8 citation statements)

References 272 publications

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“…Ultimately, however, to design useful materials, we need to understand and control molecular packing and translate properties across length scales. There are examples where useful materials have been made via hierarchical peptide assembly, − but a key question is whether we can invert the approach; rather than observing a specific behavior and then using the outcome, can we instead determine what properties would be required for a specific material and then rationally design a self-assembling system to exhibit these?…”

Section: Introductionmentioning

confidence: 99%

Transferring Micellar Changes to Bulk Properties via Tunable Self-Assembly and Hierarchical Ordering

et al. 2022

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Hierarchical self-assembly is an effective means of preparing useful materials. However, control over assembly across length scales is a difficult challenge, often confounded by the perceived need to redesign the molecular building blocks when new material properties are needed. Here, we show that we can treat a simple dipeptide building block as a polyelectrolyte and use polymer physics approaches to explain the self-assembly over a wide concentration range. This allows us to determine how entangled the system is and therefore how it might be best processed, enabling us to prepare interesting analogues to threads and webs, as well as films that lose order on heating and “noodles” which change dimensions on heating, showing that we can transfer micellar-level changes to bulk properties all from a single building block.

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Section: Introductionmentioning

confidence: 99%

Transferring Micellar Changes to Bulk Properties via Tunable Self-Assembly and Hierarchical Ordering

et al. 2022

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“…The C terminus was attached to the COOH-microspheres on the serological immunoassay. The cysteine-conjugated TIR peptide was applied in biosensor systems by Ropero-Vega et al However, the aromatic and phenylalanine residues are also able to be conjugated in the N terminus, when the material surface provides the π–π interaction . Amide can be applied when CONH could be a linker for the amide-specific surface material.…”

Section: Selection Modification and Synthesis Of Peptidementioning

confidence: 99%

“…The cysteine-conjugated TIR peptide was applied in biosensor systems by Ropero-Vega et al 109 However, the aromatic and phenylalanine residues are also able to be conjugated in the N terminus, when the material surface provides the π−π interaction. 110 Amide can be applied when CONH could be a linker for the amide-specific surface material. This mechanism can happen through the ability of the peptide in a SAM on the material surface in an electrochemical mechanism.…”

Section: Selection Modification and Synthesis Of Peptidementioning

confidence: 99%

Peptide-Based Flavivirus Biosensors: From Cell Structure to Virological and Serological Detection Methods

Muslihati,

Septiani,

Gumilar

et al. 2024

ACS Biomater. Sci. Eng.

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In tropical and developing countries, mosquito-borne diseases by flaviviruses pose a serious threat to public health. Early detection is critical for preventing their spread, but conventional methods are time-consuming and require skilled technicians. Biosensors have been developed to address this issue, but cross-reactivity with other flaviviruses remains a challenge. Peptides are essentially biomaterials used in diagnostics that allow virological and serological techniques to identify flavivirus selectively. This biomaterial originated as a small protein consisting of two to 50 amino acid chains. They offer flexibility in chemical modification and can be easily synthesized and applied to living cells in the engineering process. Peptides could potentially be developed as robust, low-cost, sensitive, and selective receptors for detecting flaviviruses. However, modification and selection of the receptor agents are crucial to determine the effectiveness of binding between the targets and the receptors. This paper addresses two potential peptide nucleic acids (PNAs) and affinity peptides that can detect flavivirus from another target-based biosensor as well as the potential peptide behaviors of flaviviruses. The PNAs detect flaviviruses based on the nucleotide base sequence of the target's virological profile via Watson−Crick base pairing, while the affinity peptides sense the epitope or immunological profile of the targets. Recent developments in the functionalization of peptides for flavivirus biosensors are explored in this Review by division into electrochemical, optical, and other detection methods.

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“…3a and 3c). Cellulosic compounds might play a role in enhancing hydrophobic and electrostatic interactions between the surfaces and the peptides, and thus improving the adsorption of both peptides [46]. Hydrophobic interactions may play a larger role in PVA/CA films due to the inherent hydrophobicity of the CA acetate groups.…”

Section: Individual Peptide Adsorption Studiesmentioning

confidence: 99%

Comparison of the Adsorption of Linear and Cyclic Antimicrobial Peptides Onto Cellulosic Compounds-Reinforced Poly(Vinyl Alcohol) Films Using Qcm-D

Teixeira,

Murthy,

Ferreira

et al. 2023

Preprint

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Hierarchical self-assembly of aromatic peptide conjugates into supramolecular polymers: it takes two to tango

Abstract: Supramolecular polymers are self-assembled materials displaying adaptive and responsive “life-like” behaviour which are often made of aromatic compounds capable of engaging in π-π interactions to form larger assemblies. Major advances...

Cited by 12 publications

References 272 publications

Transferring Micellar Changes to Bulk Properties via Tunable Self-Assembly and Hierarchical Ordering

Transferring Micellar Changes to Bulk Properties via Tunable Self-Assembly and Hierarchical Ordering

Peptide-Based Flavivirus Biosensors: From Cell Structure to Virological and Serological Detection Methods

Comparison of the Adsorption of Linear and Cyclic Antimicrobial Peptides Onto Cellulosic Compounds-Reinforced Poly(Vinyl Alcohol) Films Using Qcm-D

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