Hierarchical Self‐Assembled Photo‐Responsive Tubisomes from a Cyclic Peptide‐Bridged Amphiphilic Block Copolymer

Abstract

Typically, the morphologies of the self-assembled nanostructures from block copolymers are limited to spherical micelles, wormlike micelles and vesicles. Now, a new generation of materials with unique shape and structures, cylindrical soft matter particles (tubisomes), are obtained from the hierarchical self-assembly of cyclic peptide-bridged amphiphilic diblock copolymers. The capacity of obtained photoresponsive tubisomes as potential drug carriers is evaluated. The supramolecular tubisomes pave an alternative way for fabricating polymeric tubular structures, and will expand the toolbox for the rational design of functional hierarchical nanostructures.

Higher-order interfiber interactions in the self-assembly of benzene-1,3,5-tricarboxamide-based peptides in water

“…[2][3][4][5] Mimicking such interactions in aqueous media with synthetic supramolecular systems remains a formidable task due to the complex and frequently counterintuitive self-assembly mechanisms. 6 In the last few decades multiple supramolecular systems with hierarchical self-assembly were reported, including coordination complexes, [7][8][9] porphyrins, 10 different peptides [11][12][13][14] including di-and tri-peptides with different motifs; 15,16 as well as synthetic 17,18 and natural 19,20 polymers. Multi-level control over self-assembly has paved the way for the development of novel advanced materials in medicine and industry; [21][22][23] however, their complexity remains distant from that observed in nature.…”

Photoactivation Strategies for Therapeutic Release in Nanodelivery Systems

“…reported DOX‐loaded cylinder‐shaped tubisomes made of cyclic peptide‐bridged photocleavable copolymers ( Figure A). [ 209 ] The tubisome disassembly occurred rapidly after irradiation at 365 nm, and DOX release that followed was consistent with the induction of cytotoxicity in breast cancer cells. Sun et al.…”

“…Lai et al reported fluorescein-loaded mesoporous silica nanoparticle (MSN) grafted with ONB-caged poly(N-isopropylacrylamide-co-acrylate) polymer on its porous surface. Under an ambient condition, its pores remained closed due to its randomly collapsed polymer brushes [ 207,208] HA polymer micelle DOX ONB [ 210] Polymer micelle-aptamer Sgc8 DOX ONB [ 211] Polymer tubisome DOX ONB (365) [ 209] UCN@polymer micelle DOX ONB (980) [ 212,215] Crosslinked polymer micelle DOX [2+2] Addition (254) [ 217] Polymer micelle DOX Coumarin (430) [ 213] NP aggregate Camptothecin 2-Nitroresorcinol (UV-vis) [ 214] UCN@siRNA siRNA ONB (980) [ 216] Liposome Gd(II) complex ONB (400) [ 205] Liposome Carboxyfluorescein ONB (365) [ 204] Polymer micelle Nile red ONB (365), BODIPY (470) [ 119,206] Gating mSiO 2 @Polymer -ONB [ 218] AuNS@mSiO 2 DOX ONB (980) [ 219] UCN@mSiO 2 Fluorescein ONB (980) [ 220] mSiO 2 Rhodamine Ru-S (455) [ 221] UCN@mSiO 2 DOX Ru-S (977) [ 222] ( Figure 9A). [218] However, under UV irradiation, they observed pore opening that allowed payload diffusion.…”

Tubular supramolecular alternating copolymers fabricated by cyclic peptide–polymer conjugates

“…[37][38][39][40] Conjugating polymers onto cyclic peptides prevents their lateral aggregation and improves their stability and solubility, forming tubular supramolecular polymers with core-shell structures. [41][42][43][44][45][46][47] Tubular supramolecular copolymers could be easily fabricated by mixing different cyclic peptide-polymer conjugates, which has been conrmed by attaching Förster resonance energy transfer (FRET) dyes onto the conjugates. [48][49][50] Supramolecular statistical copolymers are expected to form as there are no differences regarding the driving forces between the two conjugates.…”