Hierarchical porous bacterial cellulose scaffolds with natural biomimetic nanofibrous structure and a cartilage tissue-specific microenvironment for cartilage regeneration and repair

Li, Yaqiang; Xun, Xiaowei; Xu, Yong; Zhan, Anqi; Gao, Erji; Fan, Yu; Wang, You; Luo, Honglin; Yang, Chunxi

doi:10.1016/j.carbpol.2021.118790

Cited by 27 publications

(16 citation statements)

References 48 publications

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Section: Smart Scaffoldmentioning

confidence: 99%

“…This BC/DCECM scaffold exhibited excellent water super‐absorbency and shape memory properties, which achieved satisfactory articular cartilage tissue regeneration in vitro and vivo research (Figure 10E). [ 217 ]…”

Section: Smart Scaffoldmentioning

confidence: 99%

mentioning

confidence: 99%

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Smart Biomaterials for Articular Cartilage Repair and Regeneration

Wang

et al. 2023

Adv Funct Materials

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Articular cartilage defects bring about disability and worldwide socioeconomic loss, therefore, articular cartilage repair and regeneration is recognized as a global issue. However, due to its avascular and nearly acellular characteristic, cartilage tissue regeneration ability is limited to some extent. Despite the availability of various treatment methods, including palliative drugs and surgical regenerative therapy, articular cartilage repair and regeneration still face major challenges due to the lack of appropriate methods and materials. Smart biomaterials can regulate cell behavior and provide excellent tissue repair and regeneration microenvironment, thus inducing articular cartilage repair and regeneration. This process is adjusted by controlling drug/bioactive factors release via responding to exogenous/endogenous stimuli, tailoring materials’ structure and function similar to native cartilage or providing physiochemical and physical signaling factors. Herein, smart biomaterials, recently applied in articular cartilage repair and regeneration, are elaborated from two aspects: smart drug release system and smart scaffolds. Furthermore, articular cartilage and its defects and advanced manufacturing techniques of smart biomaterials are discussed in brief. Finally, perspectives for smart biomaterials used in articular cartilage repair and regeneration are presented and the clinical translation of smart biomaterials is emphasized.

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Section: Smart Scaffoldmentioning

confidence: 99%

Section: Smart Scaffoldmentioning

confidence: 99%

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Smart Biomaterials for Articular Cartilage Repair and Regeneration

Wang

et al. 2023

Adv Funct Materials

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“…Li et al [ 142 ] fabricated a 3D hierarchical porous BC/decellularised cartilage extracellular matrix (DCECM) scaffold using a freeze-drying technique after chemical crosslinking with N-hydroxysuccinimide (NHS)/N-[3-(dimethylamino)propyl]-N′-ethyl carbodiimide hydrochloride (EDC). This scaffold showed excellent cell adhesion and proliferation of chondrocyte cells derived from rabbits.…”

Section: Application Of Blends and Composites Of Bc In Tissue Enginee...mentioning

confidence: 99%

Bacterial Cellulose-Based Blends and Composites: Versatile Biomaterials for Tissue Engineering Applications

Raut

Asare

Mohamed

et al. 2023

IJMS

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Cellulose of bacterial origin, known as bacterial cellulose (BC), is one of the most versatile biomaterials that has a huge potential in tissue engineering due to its favourable mechanical properties, high hydrophilicity, crystallinity, and purity. Additional properties such as porous nano-fibrillar 3D structure and a high degree of polymerisation of BC mimic the properties of the native extracellular matrix (ECM), making it an excellent material for the fabrication of composite scaffolds suitable for cell growth and tissue development. Recently, the fabrication of BC-based scaffolds, including composites and blends with nanomaterials, and other biocompatible polymers has received particular attention owing to their desirable properties for tissue engineering. These have proven to be promising advanced materials in hard and soft tissue engineering. This review presents the latest state-of-the-art modified/functionalised BC-based composites and blends as advanced materials in tissue engineering. Their applicability as an ideal biomaterial in targeted tissue repair including bone, cartilage, vascular, skin, nerve, and cardiac tissue has been discussed. Additionally, this review briefly summarises the latest updates on the production strategies and characterisation of BC and its composites and blends. Finally, the challenges in the future development and the direction of future research are also discussed.

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“…Hence, recent efforts in the field have focused on utilizing a polymeric counterpart to impart mechanical rigidity to the biomaterial. − One of the most sustainable natural biopolymers that have been identified as a potential biomaterial is cellulose, which is the structural polysaccharide predominantly present in wood biomass. , The plant-derived cellulose and its derivatives have magnificent properties such as biocompatibility, high water content, porous structure, and tunable mechanical behavior. , Besides the inherent beneficial properties of cellulose as a natural polymer, it suffers from the major disadvantages of low dispersity in solvents and slow degradation in vivo, which restrain the applicability of cellulose toward developing advanced biomaterials. , The drawback of the native cellulose lies in the fact that it bears a large number of hydroxyl groups in its molecular domain, which forms a highly extended hydrogen-bonded hierarchical structure . Thus, to make the cellulose suitable for various applications, the native cellulose was reported to disintegrate from microfibrils to nanofibrils by breaking the hydrogen bonds holding the cellulose structure. − The nanofibrillar cellulose (NFC) has a high surface area, increased dispersion, and high mechanical strength, in addition to the inherent features of cellulose such as biocompatibility, biodegradability, nontoxicity, and hydrophilicity, which makes the NFC to act as a suitable candidate for creating a biomaterial scaffold for tissue engineering. ,− …”

Section: Introductionmentioning

confidence: 99%

Exploring Supramolecular Interactions between the Extracellular-Matrix-Derived Minimalist Bioactive Peptide and Nanofibrillar Cellulose for the Development of an Advanced Biomolecular Scaffold

Kaur¹,

Sharma²,

Pal³

et al. 2023

ACS Biomater. Sci. Eng.

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It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system. Despite their unique biocompatible features, both polymer- and peptide-based scaffolds suffer from certain limitations, which restrict their use toward developing efficient matrices for controlling cellular behavior. The peptide hydrogels usually form soft matrices with low mechanical strength, whereas most of the polymer hydrogels lack biofunctionality. In this direction, combining polymers with peptides to develop a conjugate hydrogel can be explored as an emergent approach to overcome the limitations of the individual components. The polymer will provide high mechanical strength, whereas the biofunctionality of the material can be induced by the bioactive peptide sequence. In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC–peptide conjugate hydrogel. Interestingly, the mechanical strength of the peptide hydrogel was found to be significantly improved by combining the peptide with the NFC in the conjugate hydrogel. The addition of the peptide into the NFC also reduced the pore size within NFC matrices, which further helped in improving cellular adhesion, survival, and proliferation. Furthermore, the cells grown on the NFC and NFC–peptide hybrid hydrogel demonstrated normal expression of cytoskeleton proteins, i.e., β-tubulin in C6 cells and actin in L929 cells, respectively. The selective response of neuronal cells toward the specific bioactive peptide was further observed through a protein expression study. Thus, our study demonstrated the collective role of the cellulose–peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications.

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Hierarchical porous bacterial cellulose scaffolds with natural biomimetic nanofibrous structure and a cartilage tissue-specific microenvironment for cartilage regeneration and repair

Cited by 27 publications

References 48 publications

Smart Biomaterials for Articular Cartilage Repair and Regeneration

Smart Biomaterials for Articular Cartilage Repair and Regeneration

Bacterial Cellulose-Based Blends and Composites: Versatile Biomaterials for Tissue Engineering Applications

Exploring Supramolecular Interactions between the Extracellular-Matrix-Derived Minimalist Bioactive Peptide and Nanofibrillar Cellulose for the Development of an Advanced Biomolecular Scaffold

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