Hierarchical or Not? Effect of the Length Scale and Hierarchy of the Surface Roughness on Omniphobicity of Lubricant-Infused Substrates

Kim, Philseok; Kreder, Michael J.; Alvarenga, Jack; Aizenberg, Joanna

doi:10.1021/nl4003969

Cited by 435 publications

(438 citation statements)

References 46 publications

Supporting

Mentioning

421

Contrasting

Unclassified

Order By: Relevance

“…The TP we used was covalently coupled to the surface by silane chemistry that is used in dental adhesives, but other reactive groups could be utilized to generate TP layers 26 . The LP perfluorodecalin used here has been previously included in an FDA-approved blood substitute; however, we have found that a variety of LPs, medical grade and non-medical grade, also can repel blood when integrated into a TLP coating (Supplementary Fig.…”

Section: Discussionmentioning

confidence: 99%

“…2). These TLP-coated smooth surfaces also were equally as effective as porous materials (expanded PTFE, colloidal monolayers and nanostructured boehmite) that were infused with LP, the original SLIPS technology (e.SLIPS and B.SLIPS, respectively), which have previously been shown to repel crude oil and ice, as well as anticoagulated animal blood 20,26,27 . Additionally, an acrylic sheet and a commercial PP tube modified with the TLP coating showed no blood adhesion after immersion in human blood, which was in stark contrast to the control…”

Section: Supplementary Movie 1)mentioning

confidence: 99%

See 1 more Smart Citation

A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

et al. 2014

Self Cite

View full text Add to dashboard Cite

________________________________________________________________Countless lives have been saved by implantable medical devices (e.g., total artificial hearts, ventricular assist devices, pacemakers, cardioverterdefibrillators, and central lines) and extracorporeal devices that flow whole human blood outside the body through indwelling catheters and external circuits, during cardiopulmonary bypass (CPB), hemodialysis, and extracorporeal membrane oxygenation (ECMO) 1,2 . However, the need to co-administer soluble anticoagulant drugs, such as heparin, with many of these procedures, significantly reduces their safety and hampers their effectiveness 3,4 . Without systemic anticoagulation, these extracorporeal and indwelling devices can rapidly occlude due to thrombosis because clots form when fibrin and platelets in the flowing blood adhere to the surfaces of these artificial materials 5 . Unfortunately, heparin causes significant morbidity and mortality including post-operative bleeding, thrombocytopenia, hypertriglyceridemia, hyperkalemia and hypersensitivity 6 , and its use is contraindicated in several patient populations 7 . In fact, the majority of drug-related deaths from adverse clinical events in the UnitedStates are due to systemic anticoagulation 8 .This need to prevent blood clotting while minimizing administration of anticoagulant drugs has led to the search for biomaterial surface coatings that can directly suppress blood clot formation. The most successful approach to date has been to chemically immobilize heparin on blood-contacting surfaces to reduce thrombosis and lower anticoagulant administration 9,10 . Although this approach has been widely adopted, major limitations persist because the surface-bound heparin leaches, resulting in a progressive loss of anticoagulation 24,25 . Importantly, the TP continues to retain the free LP as a thin mobile liquid layer even when the surface is challenged with a flowing immiscible fluid, such as blood (Fig. 1a). We refer to this unique anti-thrombogenic bilayer composed of the TP and LP coating as a Tethered-Liquid Perfluorocarbon (TLP) surface. RESULTS A generic blood repellent surface coatingTo test the anti-adhesive properties of the TLP coating method, we examined surface adhesion of fresh whole human blood on an acrylic surface sloped at an angle of 30 degrees, with or without a TLP coating composed of tethered perfluorohexane and liquid perfluorodecalin. Blood droplets immediately adhered to the control uncoated acrylic surface and left a trail of blood components over the course of 5 sec (Fig. 1b, top, Supplementary Fig. 1 and Supplementary Movie 1).In contrast, when the same surface was coated with TLP, the blood droplet almost immediately slid off the surface (< 0.3 sec), and remarkably, there was no evidence of any residual blood trail (Fig. 1b, Supplementary Fig. 1 and Supplementary Movie 2). We quantified blood adhesion to surfaces by measuring the minimum angle required to cause a droplet to slide ("sliding angle") ( Fig. 1c). Control uncoated s...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Supplementary Movie 1)mentioning

confidence: 99%

A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…Since these properties can all be incorporated into a single coating, new approaches of forming such coatings on a broad variety of materials, such as metals, ceramics, or polymers, are being developed. 91 The slippery surfaces can potentially be used in a wide variety of industrial and medical applications and environments and may provide alternative solutions for designing materials with special wettability that could not be addressed by conventional lotus leaf-inspired surfaces. 92 Ultimately, the widespread application of any of the aforementioned bioinspired interfacial materials is dictated by their cost, scalability, and robustness, which are important for their practical use on a large scale and accessibility to people with low budgets and around the world.…”

Section: Discussionmentioning

confidence: 99%

Interfacial materials with special wettability

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, the requirements to sustain repellency throughout an endoscopic procedure are extremely challenging because (i) direct contact with proteins, cells, and bacteria, as well as the formation of blood clots upon contact with an abiotic surface, compromise the performance of superhydrophobic surfaces (11,12), and (ii) their transparency is not easily achievable. Recently, liquid-infused coatings, consisting of a porous structure infiltrated with a lubricant, have emerged as a new, alternative strategy for repellent materials (11,(13)(14)(15)(16)(17). The formation of a stable lubricant overlayer on the surface creates a dynamic slippery barrier that protects the underlying substrate from direct contact with polluted media, thus drastically lowering the adsorption of various serious contaminants including bacteria (18,19) and proteins (20)(21)(22).…”

Section: Significancementioning

confidence: 99%

Transparent antifouling material for improved operative field visibility in endoscopy

Sunny

Cheng

Daniel

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

115

125

View full text Add to dashboard Cite

Camera-guided instruments, such as endoscopes, have become an essential component of contemporary medicine. The 15–20 million endoscopies performed every year in the United States alone demonstrate the tremendous impact of this technology. However, doctors heavily rely on the visual feedback provided by the endoscope camera, which is routinely compromised when body fluids and fogging occlude the lens, requiring lengthy cleaning procedures that include irrigation, tissue rubbing, suction, and even temporary removal of the endoscope for external cleaning. Bronchoscopies are especially affected because they are performed on delicate tissue, in high-humidity environments with exposure to extremely adhesive biological fluids such as mucus and blood. Here, we present a repellent, liquid-infused coating on an endoscope lens capable of preventing vision loss after repeated submersions in blood and mucus. The material properties of the coating, including conformability, mechanical adhesion, transparency, oil type, and biocompatibility, were optimized in comprehensive in vitro and ex vivo studies. Extensive bronchoscopy procedures performed in vivo on porcine lungs showed significantly reduced fouling, resulting in either unnecessary or ∼10–15 times shorter and less intensive lens clearing procedures compared with an untreated endoscope. We believe that the material developed in this study opens up opportunities in the design of next-generation endoscopes that will improve visual field, display unprecedented antibacterial and antifouling properties, reduce the duration of the procedure, and enable visualization of currently unreachable parts of the body, thus offering enormous potential for disease diagnosis and treatment.

show abstract

Hierarchical or Not? Effect of the Length Scale and Hierarchy of the Surface Roughness on Omniphobicity of Lubricant-Infused Substrates

Cited by 435 publications

References 46 publications

A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

Interfacial materials with special wettability

Transparent antifouling material for improved operative field visibility in endoscopy

Contact Info

Product

Resources

About