Hierarchical Nanomaterials Assembled from Peptoids and Other Sequence-Defined Synthetic Polymers

Li, Zhiliang; Cai, Bin; Yang, Wenxuan; Chen, Chun‐Long

doi:10.1021/acs.chemrev.1c00024

Cited by 68 publications

(73 citation statements)

References 316 publications

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“…In this context, we developed a class of self-assembled peptoid/hemin (Pep/hemin) nanomaterials with tunable active sites and microenvironments that mimic peroxidases for lignin depolymerization, by taking advantage of the high tunability of peptoids (or poly- N -substituted glycines) and the uniqueness of their self-assembled crystalline nanomaterials in aligning active sites 15 – 18 . Compared to peptides, peptoids can be easily synthesized to achieve a greater side chain diversity while exhibiting much higher chemical and thermal stabilities 15 – 22 . Our recent work has shown that tuning amphiphilic peptoids can lead to the formation of hierarchically structured crystalline nanomaterials 17 , 18 , 23 – 28 , including membrane-mimetic 2D nanosheets 15 , 23 , 29 and nanotubes 16 , 25 , 28 .…”

Section: Introductionmentioning

confidence: 99%

Highly stable and tunable peptoid/hemin enzymatic mimetics with natural peroxidase-like activities

et al. 2022

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Developing tunable and stable peroxidase mimetics with high catalytic efficiency provides a promising opportunity to improve and expand enzymatic catalysis in lignin depolymerization. A class of peptoid-based peroxidase mimetics with tunable catalytic activity and high stability is developed by constructing peptoids and hemins into self-assembled crystalline nanomaterials. By varying peptoid side chain chemistry to tailor the microenvironment of active sites, these self-assembled peptoid/hemin nanomaterials (Pep/hemin) exhibit highly modulable catalytic activities toward two lignin model substrates 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and 3,3’,5,5’-tetramethylbenzidine. Among them, a Pep/hemin complex containing the pyridyl side chain showed the best catalytic efficiency (Vmax/Km = 5.81 × 10−3 s−1). These Pep/hemin catalysts are highly stable; kinetics studies suggest that they follow a peroxidase-like mechanism. Moreover, they exhibit a high efficacy on depolymerization of a biorefinery lignin. Because Pep/hemin catalysts are highly robust and tunable, we expect that they offer tremendous opportunities for lignin valorization to high value products.

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Section: Introductionmentioning

confidence: 99%

Highly stable and tunable peptoid/hemin enzymatic mimetics with natural peroxidase-like activities

et al. 2022

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“…The great potential inherent in foldamers results from the possibility of extending the alphabet with abiotic monomers. Furthermore, the development of precision polymer chemistry methods [ 154 , 155 , 156 ] leading to sequence-defined macromolecules provides opportunities for new types of foldamers based on an abiotic backbone [ 157 , 158 , 159 , 160 , 161 ].…”

Section: Foldamers In Sensingmentioning

confidence: 99%

Shaping Macromolecules for Sensing Applications—From Polymer Hydrogels to Foldamers

et al. 2022

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Sensors are tools for detecting, recognizing, and recording signals from the surrounding environment. They provide measurable information on chemical or physical changes, and thus are widely used in diagnosis, environment monitoring, food quality checks, or process control. Polymers are versatile materials that find a broad range of applications in sensory devices for the biomedical sector and beyond. Sensory materials are expected to exhibit a measurable change of properties in the presence of an analyte or a stimulus, characterized by high sensitivity and selectivity of the signal. Signal parameters can be tuned by material features connected with the restriction of macromolecule shape by crosslinking or folding. Gels are crosslinked, three-dimensional networks that can form cavities of different sizes and forms, which can be adapted to trap particular analytes. A higher level of structural control can be achieved by foldamers, which are macromolecules that can attain well-defined conformation in solution. By increasing control over the three-dimensional structure, we can improve the selectivity of polymer materials, which is one of the crucial requirements for sensors. Here, we discuss various examples of polymer gels and foldamer-based sensor systems. We have classified and described applied polymer materials and used sensing techniques. Finally, we deliberated the necessity and potential of further exploration of the field towards the increased selectivity of sensory devices.

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“…Synthetic polymers have attracted the attention of scientists as they exhibit excellent biocompatibility, flexibility, physical strength, biodegradability, and low immunogenicity. [5,6] Among these polymers, the use of polyurethane (PU) has been widely reported in the literature as it is biocompatible, flexible, and modifiable. Toxic degradation products are not produced when PU is used.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Polyurethane Conduit Grafted with Vascular Endothelial Growth Factor‐Loaded Hydrogel Repairs the Peripheral Nerve Defect in Rats

Zhang

Lü

et al. 2021

Macromolecular Bioscience

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Artificial nerve guidance conduits (NGCs) can be potentially used to address the problems of peripheral nerve defects. The biomaterial polyurethane (PU) has already been used to construct NGCs. However, the use of a combination of PU-based NGCs and other bioactive cues, such as extracellular matrix proteins and growth factors, has not been reported yet. A PU conduit grafted with a vascular endothelial growth factor (VEGF)-loaded hydrogel (abbreviated as PU/Gel/VEGF conduit) is fabricated. The leachate generated during the use of the PU/Gel/VEGF conduit could facilitate the proliferation, migration, and expression of the neural marker S100𝜷 in RSC96 cells (in vitro). The walking track and target muscle are analyzed, and it is observed that PU/Gel/VEGF conduits promote the functional recovery of the injured side. Various histological staining analyses are carried out, and the results reveal that the PU/Gel/VEGF conduit effectively improves the extent of nerve regeneration achieved. The number of blood vessels developed during the regeneration of the axons in the PU/Gel/VEGF group (attributable to the pro-angiogenic effect of the functional NGC) is higher than the number of blood vessels developed in the PU/Gel conduit. Overall, the results indicate that PU/Gel/VEGF conduits could promote the process of peripheral nerve regeneration.

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Hierarchical Nanomaterials Assembled from Peptoids and Other Sequence-Defined Synthetic Polymers

Cited by 68 publications

References 316 publications

Highly stable and tunable peptoid/hemin enzymatic mimetics with natural peroxidase-like activities

Highly stable and tunable peptoid/hemin enzymatic mimetics with natural peroxidase-like activities

Shaping Macromolecules for Sensing Applications—From Polymer Hydrogels to Foldamers

Biocompatible Polyurethane Conduit Grafted with Vascular Endothelial Growth Factor‐Loaded Hydrogel Repairs the Peripheral Nerve Defect in Rats

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