Hierarchical functional system development supports executive function

Keller, Arielle S.; Sydnor, Valerie J.; Pines, Adam; Fair, Damien A.; Bassett, Dani S.; Satterthwaite, Theodore D.

doi:10.1016/j.tics.2022.11.005

Cited by 46 publications

(39 citation statements)

References 120 publications

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“…The Developmental Origins of Health and Disease hypothesis suggests that experiences beginning in gestation may adaptively tune the structure and function of emergent and malleable biological systems, possibly to prepare the developing fetus for "forecasted" conditions postnatally (Gluckman et al, 2007). The brain is a likely target for a potent hit in gestation and infancy as it develops most rapidly in utero through the fourth postnatal month (W. Thompson, 2020), followed by a protracted period of elaboration and refinement of functional brain networks (W. Keller et al, 2023). Functional adaptations may serve to narrow the range of possible phenotypes a fetus or infant may express, to better fit anticipated conditions.…”

Section: First Hit: Gestation and Infancymentioning

confidence: 99%

A two-hit model of behavioral inhibition and anxiety

Ostlund¹,

Pérez‐Edgar²

2023

Preprint

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Four decades of research has examined the antecedents and consequences of behavioral inhibition (BI), a temperament profile associated with heightened reactivity to sensory stimuli in infancy, reticence towards social cues in childhood, and the later emergence of social anxiety in adolescence. This review proposes that a two-hit model can supplement prior work to better understand these developmental pathways. Specifically, time limited experiences (“hits”) centered in infancy and adolescence stress idiosyncratic BI-linked processes that uniquely trigger the developmental pathway from temperament to disorder. To illustrate, we focus on caregiver distress in infancy (including fetal development) and social reorientation in adolescence, and the impact on malleable attentional and cognitive systems. These are developmental challenges and processes that go to the heart of the BI phenotype. Finally, we note open questions in this conceptual model, potential caveats, and needed future research.

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Section: First Hit: Gestation and Infancymentioning

confidence: 99%

A two-hit model of behavioral inhibition and anxiety

Ostlund¹,

Pérez‐Edgar²

2023

Preprint

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“…Within this context, the recently described spatial gradients of functional integration from primary sensory network to transmodal hierarchy may allow to determine the precise alterations 8,9,10 . Hierarchical organization changes in the primary-to-transmodal cortex during childhood and its developmental trajectories may support a facilitation of cognition, such as working memory and attention 11,12 . A recent study suggested dysfunctional pattern of the primary-to-transmodal connectome gradient in childhood-onset autism spectrum disorder, which may underlie neurodevelopmental deficits in social interaction and cognition during childhood 13 .…”

Section: Introductionmentioning

confidence: 99%

Cortical gradient perturbation in attention deficit hyperactivity disorder correlates with neurotransmitter-, cell type-specific and chromosome- transcriptomic signatures

Chen

Liu

et al. 2023

Preprint

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Neurofunctional dysregulations in spatially discrete areas or isolated pathways have been suggested as neural markers for attention deficit hyperactivity disorder (ADHD). However, multiscale perspectives into the neurobiological underpins of ADHD spanning multiple biological systems remain sparse. This points to the need of multi-levels of analysis encompassing brain functional organization and its correlation with molecular and cell-specific transcriptional signatures are stressed. Here, we capitalized on diffusion mapping embedding model to derive the functional connectome gradient, and deployed multivariate partial least square (PLS) method to uncover the enrichment of neurotransmitomic, cellular and chromosomal connectome-transcriptional signatures of ADHD. Compared to typical control, ADHD children presented connectopic cortical perturbations in lateral orbito-frontal and superior temporal regions, which had also been validated in another independent sample. This gradient-derived variants in ADHD further aligned spatially with distributions of GABAA/BZ and 5-HT2A receptors and co-varied with genetic transcriptional expression. Cognitive decoding and gene-expression annotation showed the correlates of these variants in memory, emotional regulation and spatial attention. Moreover, the gradient-derived transcriptional signatures of ADHD exhibited enriched expression of oligodendrocyte precursors and endothelial cells, and were mainly involved as variants of chromosome 18, 19 and X. In conclusion, our findings bridged in-vivo neuroimging assessed functional brain organization patterns to a multi-level molecular pathway in ADHD, possibly shedding light on the interrelation of biological systems that may coalesce to the emergence of this disorder.

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“…Connectome-based predictive modeling (CPM) is an approach that identifies functional connectivity networks (here connectivity is correlated fMRI activity time-courses of pairs of brain regions) that are related to behavior and measures the strength of these networks in previously unseen individuals to make predictions about their behavior [Shen et al, 2017]. Since adolescence is a critical period for the development of attention and working memory and the brain networks supporting them [Spear, 2013;Keller et al, 2022;Kardan et al, 2022], it is possible that environmental influences such as exposure to PM2.5 and NO2 may influence this protracted [Keller et al, 2022] neurobehavioral development.…”

Section: Introductionmentioning

confidence: 99%

Neighborhood air pollution is negatively associated with neurocognitive maturation in early adolescence

Kardan

Sereeyothin

Schertz

et al. 2023

Preprint

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The ability to maintain focus and process task-relevant information continues developing during adolescence, but the specific physical environmental factors that influence this development remain poorly characterized. One candidate factor is air pollution. Evidence suggests that small particulate matter and NO2 concentrations in the air may negatively impact cognitive development in childhood. We assessed the relationship between neighborhood air pollution and the changes in performance on the n-back task, a test of attention and working memory, in the Adolescent Brain Cognitive Development (ABCD) Study's baseline (ages 9-10) and two- year-follow-up releases (Y2, ages 11-12; n = 5,256). In the behavioral domain, multiple linear regression showed that developmental change in n-back task performance was negatively associated with neighborhood air pollution (beta = -.044, t = -3.11, p = .002), adjusted for covariates capturing baseline cognitive performance of the child, their parental income and education, family conflicts, and their neighborhood's population density, crime rate, perceived safety, and Area Deprivation Index (ADI). The strength of the adjusted association for air pollution was similar to parental income, family conflict, and neighborhood ADI. In the neuroimaging domain, we again found that decreased developmental change in the strength of the ccCPM from pre- to early adolescence was associated with neighborhood air pollution (beta = -.110, t = -2.69, p = .007), adjusted for the covariates mentioned above and head motion. Finally, we found that the developmental change in ccCPM strength was predictive of the developmental change in n-back performance (r = .157, p < .001), and there was an indirect-only mediation where the effect of air pollution on change in n-back performance was mediated by the change in the ccCPM strength (beta for indirect effect = -.013, p = .029). In conclusion, neighborhood air pollution is associated with lags in the maturation of youth cognitive performance and decreased strengthening of the brain networks supporting cognitive abilities over time.

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Hierarchical functional system development supports executive function

Cited by 46 publications

References 120 publications

A two-hit model of behavioral inhibition and anxiety

A two-hit model of behavioral inhibition and anxiety

Cortical gradient perturbation in attention deficit hyperactivity disorder correlates with neurotransmitter-, cell type-specific and chromosome- transcriptomic signatures

Neighborhood air pollution is negatively associated with neurocognitive maturation in early adolescence

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