Hierarchical contribution of individual lifestyle factors and their interactions on adenomatous and serrated polyp risk

Kim, Jihee; Nath, Kirti; Schmidlin, Kurt; Schaufelberger, H. D.; Quattropani, Christiana; Vannini, Simone; Mossi, Sandro; Thumshirn, Miriam; Manz, Markus G.; Litichevskiy, Lev; Fan, Jiaxin; Dmitrieva-Posocco, Oxana; Li, Mingyao; Levy, Maayan; Schär, Primo; Zwahlen, Marcel; Thaiss, Christoph A.; Truninger, Kaspar

doi:10.1007/s00535-023-02004-8

Cited by 5 publications

(2 citation statements)

References 22 publications

(21 reference statements)

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“…Previous research had shown that individual lifestyle, age, and Western dietary pattern were associated with the risk of colorectal adenoma, smoking was associated with the occurrence of serrated polyps, diabetes was associated with sessile serrated lesions, and family history of colorectal cancer was not associated with adenoma and serrated polyps [19] . Smoking, alcohol, body mass index, and a high intake of fat or meat were risk factors for serrated polyps, while nonsteroidal anti-inflammatory medications and a high fiber intake were protective factors [20] .…”

Section: Discussionmentioning

confidence: 94%

“…Increasing age, polyp diameter ≥1.0cm, multiple polyps, and a high CA199 level were all risk factors for the development of neoplastic polyps in individuals. Age, male gender and diabetes have all been linked to an increased incidence of metachronous advanced neoplasia, according to research [18] , moreover, male gender was a risk factor for overall colorectal polyps [19] . However, no differences in gender, hypertension, diabetes, coronary heart disease, MAFLD, or Helicobacter pylori current infection were found between colorectal carcinoma in situ and neoplastic polyps in this investigation.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polyps

Li,

Hu,

Wang

et al. 2023

Preprint

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Purposes: Colorectal cancer, which accounts for 10.0% of all cancers worldwide and is the second leading cause of cancer death. The majority of colorectal cancer begins as precancerous polyps. This study aimed to determine the incidence of colorectal polyps with diverse pathological morphologies and to explore the risk factors of colorectal carcinoma in situ and neoplastic polyps. Methods: Inpatients from January 2018 to May 2023 were screened through the inpatient electronic medical database. According to the pathological morphology of polyps, they were divided into hyperplastic polyps, inflammatory polyps, juvenile polyps, tubular adenoma, tubulovillous adenoma, serrated adenoma, and carcinoma in situ polyps. The incidence of polyps was described by percentage and odds ratio(OR). Univariate and multivariate logistic regression analyses were used to explore the risk factors of carcinoma in situ and neoplastic polyps. Results: In total, 2329 individuals with 3550 polyps were recruited, 64.92% were male, with a mean age of 60.38±12.08 years. Neoplastic polyps accounted for 76.99%, advanced adenomas for 44.31%, and multiple polyps for 48.65% of all patients with colorectal polyps. The incidence of various pathological polyps was 60.15% (95%CI 58.16%–62.14%) for tubular adenoma, 31.22% (95%CI 29.33%–33.10%) for hyperplastic polyps, 26.62% (95%CI 24.82%–28.42%) for inflammatory polyps, 26.02% (95%CI 24.24%–27.80%) for tubulovillous adenoma, 4.16% (95%CI 3.35%–4.98%) for serrated adenoma, 3.86% (95%CI 3.08%–4.65%) for carcinoma in situ, and 0.39%for juvenile polyps (95%CI 0.13%–0.64%). Subsequently, we analyzed the risk factors of colorectal polyps in patients with carcinoma in situ and found that the number of polyps in patients with colorectal polyps ≥3, diameter ≥1.0cm, Schistosome egg deposition, CA724, CA211 were risk factors for colorectal carcinoma in situ. Colorectal polyps diameter ≥1.0cm were 8.07 times more likely to develop carcinoma in situ than those with a diameter <1.0cm, OR 8.07,95%CI 4.48–14.55, p<0.0001. Colorectal polyps ≥3 were 1.98 times more likely to develop carcinoma in situ than those with polyps <3, OR 1.98,95%CI 1.27–3.09, p=0.002. The risk of colorectal carcinoma in situ with Schistosome egg deposition was also significantly increased (OR 2.70,95%CI 1.05–6.98). The higher the levels of CA724 (OR 1.01,95%CI 1.00–1.02) and CA211 (OR 1.16,95%CI 1.03–1.32) in patients with colorectal polyps, the greater the risk of carcinoma in situ. When colorectal neoplastic polyps and non-neoplastic polyps were compared, it was discovered that for each 1-year rise in age, the risk of neoplastic polyps increased by 3% (OR1.03,95%CI 1.02–1.04), p<0.0001. Compared to colorectal polyp diameter <1.0cm, the risk of neoplastic polyps in patients with polyp diameter ≥1.0cm increased by 2.11 times (OR 3.11,95%CI 2.48–3.92), p<0.0001. In addition, multiple polyps and CA199 levels are risk factors for neoplastic polyps. Conclusion: The pathological morphology of colorectal polyps was primarily tubular adenoma and tubulovillous adenoma, and more than 3/4 of them were neoplastic polyps, among which advanced adenoma contributed 44.31%. The prevalence of carcinoma in situ polyps in the population and polyps was, respectively, 3.86% and 2.54%. Patients are more inclined to develop colorectal carcinoma in situ and neoplastic polyps if they have large polyps (>1.0 cm) and multifocal polyps. The levels of the tumor markers CA724 and CA211 show some potential usefulness for predicting colorectal carcinoma in situ, which may be exploited for early identification of high-risk populations.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Prevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polyps

Li,

Hu,

Wang

et al. 2023

Preprint

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The prognostic and immune significance of SLAMF9 in pan-cancer and validation of its role in colorectal cancer

Zhao,

Zhu,

Liu

et al. 2024

Sci Rep

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SLAMF9, a member of the conserved lymphocyte activation molecules family (SLAMF), has been less investigated compared to other SLAMs, especially concerning its implications across various cancer types. In our systematic pan-cancer investigation, we observed elevated SLAMF9 expression in various tumor tissues, which was correlated with reduced patient survival across most malignancies. Correlation analyses further revealed significant associations between SLAMF9 expression and immune cell infiltrates, immune checkpoint inhibitors, tumor mutation load, microsatellite instability, and epithelial-mesenchymal transition (EMT) scores. Cell-based assays demonstrated that SLAMF9 knockdown attenuated the proliferative, motile, and invasive capacities of colorectal cancer (CRC) cells. In a nude mouse xenograft model, suppression of SLAMF9 expression substantially inhibited tumor growth. These findings highlight the potential of SLAMF9 as a prognostic and therapeutic biomarker across tumors, with notable implications for CRC cell proliferation and migration.

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DNA-methylation variability in normal mucosa: a field cancerization marker in patients with adenomatous polyps

Yates,

Schaufelberger,

Steinacher

et al. 2024

JNCI: Journal of the National Cancer Institute

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Background The phenomenon of field cancerization reflects the transition of normal cells into those predisposed to cancer. Assessing the scope and intensity of this process in the colon may support risk prediction and colorectal cancer prevention. Methods The SWEPIC study, encompassing 1,111 participants for DNA methylation analysis and a subset of 84 for RNA-seq, was employed to detect field cancerization in individuals with adenomatous polyps (AP). Methylation variations were evaluated for their discriminative capability, including in external cohorts, genomic localization, clinical correlations, and associated RNA expression patterns. Results Normal cecal tissue of individuals harboring an AP in the proximal colon manifested dysregulated DNA methylation compared to tissue from healthy individuals at 558 unique loci. Leveraging these adenoma-related differentially variable and methylated CpGs (aDVMCs), our classifier discerned between healthy and AP-adjacent tissues across SWEPIC datasets (cross-validated ROC AUC [0.63-0.81]), including within age-stratified cohorts. This discriminative capacity was validated in three external sets, differentiating healthy from cancer-adjacent tissue (ROC AUC: [0.82-0.88]). Notably, aDVMC dysregulation correlated with polyp multiplicity. More than 50% of aDVMCs were significantly associated with age. These aDVMCs were enriched in active regions of the genome (p < .001), and associated genes exhibited altered expression in AP-adjacent tissues. Conclusions Our findings underscore the early onset of field cancerization in the right colon during the neoplastic transformation process. A more extensive validation of aDVMC dysregulation as a stratification tool could pave the way for enhanced surveillance approaches, especially given its linkage to adenoma emergence.

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Hierarchical contribution of individual lifestyle factors and their interactions on adenomatous and serrated polyp risk

Cited by 5 publications

References 22 publications

Prevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polyps

Prevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polyps

The prognostic and immune significance of SLAMF9 in pan-cancer and validation of its role in colorectal cancer

DNA-methylation variability in normal mucosa: a field cancerization marker in patients with adenomatous polyps

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