In this study, the flexural properties of fully integrated honeycomb plates (FIHPs) were analyzed using experimental methods and finite element analyses. The effects of the perforated surface on the flexural properties of FIHPs were investigated by analyzing the flexural failure patterns and load-deformation curves of the FIHPs. The direction of the perforated surface has a significant influence on the flexural strength, and the structure exhibits different destruction patterns depending on the orientation. The experimental results indicate that although destruction occurs in the lower skin regardless of whether the perforated surface is up or down, the strength of the material of FIHPs can be optimized if the perforated surface faces upward because the chopped basalt fiber-reinforced epoxy resin composite material is strong in compression and weak in tension. A submodel of a thin honeycomb plate containing holes was developed to discuss these issues in detail. The analysis results suggest that the stress concentration around the hole is distinct and that cracks initially appear in this high-stress area. This paper provides some conclusions to support the better use of biological structures, and it offers some important theoretical support for the application of FIHPs in natural disaster emergency projects.