Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary‐like glands

Abstract

A case of hidradenoma papilliferum with mixed features of syringocystadenoma papilliferum (SCAP) and anogenital mammary-like glands is reported. A single, fresh red-colored nodule developed in the sulcus between the labia majora and minora of a 49-year-old Japanese woman. Histopathologically, the tumor showed epithelial lining with apocrine secretion and slight connective tissues characteristics. Our case was unique because, like SCAP, the tumor was connected to the epidermis and cystic invaginations extended downward into the deep dermis. In addition, beneath the tumor, tubular structures that resembled normal mammary tissue were present in the subcutaneous fatty tissue. In this study, it has been suggested that this tumor might have been developed from these mammary-like glands.

Hidradenoma Papilliferum With Mixed Histopathologic Features of Syringocystadenoma Papilliferum and Anogenital Mammary-Like Glands: Report of a Case and Review of the Literature

“…4 In addition, many of those variants occur in typical MLG adenomas. 4 The only previously published case of HP with SCAP and anogenital MLGs was by Nishie et al 5 In that case, it was suggested that the neoplasm originated from anogenital MLGs and might serve as a documented example of van der Putte theory. 5 We believe that the findings they presented closely resemble those in our case, which we present as further documentation of the association between anogenital MLG and HP.…”

“…48 The reported case, similar to ours, presented with mixed histology of SCAP and MLGs. 5 There are also reported cases of pseudoangiomatous stromal hyperplasia in lesions of anogenital MLGs, all with complex histology. 39,45 Although the reports of simple and complex adenomas were well described in the literature, there are other reports describing breast-like glandular proliferations arising from anogenital MLGs.…”

“…70 This case further emphasizes the importance of biopsy in vulvar lesions. Siegler and Gordon 11 1 Burger et al 12 1 Gabbrielli and Ambrosi 13 2 Foushee and Pruitt 14 1 Hassim 15 3 Assor et al 16 1 Prasad et al 17 1 Donati et al 18 1 Boscaino et al 19 1 Higgins et al 20 1 Van der Putte 21 1 Guler et al 22 2 Baisre et al 23 1 Sington et al 24 1 Ahmed et al 25 1 Atwal et al 26 1 Doganavsargil et al 27 1 Carter et al 28 1 Lin et al 29 1 Lucas et al 30 1 Cantu de Leon, 2009 31 8 Kazakov et al 32 Phyllodes tumor 1 Tbakhi et al 33 2 Tresserra et al 34 1 Chulia et al 35 1 Giger et al 36 5 Kazakov et al 32 1 Mannan et al 37 Fibrocystic changes 1 Baykal et al 38 1 Kazakov et al 39 1 Kazakov et al 40 …”

Vulval Papillary Hidradenoma Clinically Mimicking a Sebaceous Cyst- A Case Report

“…The epithelium lining the papillae is composed by a basal layer of cuboidal cells and a luminal layer of larger columnar cells showing decapitation secretion [7]. Sometimes the tumor may show a histopathology similar to syringocystadenoma papilliferum since both are closely related tumors originating from apocrine glands [8]. The differential diagnosis also includes tubular apocrine adenoma.…”

Gene expression profiling guiding diagnosis and therapy of rare mammary-like anogenital gland carcinomas

“…sclerosing adenosis [7], hidradenoma papilliferum [8], adenomas [9,10] with one reported adenoma-carcinoma sequence [11], and carcinomas in which pagetoid growth may occur [5,12]. The carcinomas were suggested to constitute a separate entity of skin cancer, even though their variable expression of apocrine, eccrine, and mammary gland features made their classification controversial [2,6].…”