Hidradenitis Suppurativa-Related Autoinflammatory Syndromes

Maronese, Carlo Alberto; Moltrasio, Chiara; Marzano, Angelo Valerio

doi:10.1016/j.det.2023.12.004

Dermatologic Clinics

2024

DOI: 10.1016/j.det.2023.12.004

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Hidradenitis Suppurativa-Related Autoinflammatory Syndromes

Carlo Alberto Maronese,

Chiara Moltrasio,

Angelo Valerio Marzano

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2024

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Cited by 6 publications

References 114 publications

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Advancements in Comorbidity Screening and Multidisciplinary Symptom Management for Hidradenitis Suppurativa

Martin,

Onajin

2024

Curr Derm Rep

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Advancements in Comorbidity Screening and Multidisciplinary Symptom Management for Hidradenitis Suppurativa

Martin,

Onajin

2024

Curr Derm Rep

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IRAK4: A Novel Target in the Therapeutic Landscape of Hidradenitis Suppurativa?

Maronese,

Piguet,

Marzano

2024

Journal of Investigative Dermatology

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Interleukin‐1 family cytokines and soluble receptors in hidradenitis suppurativa

Manzo Margiotta,

Gambino,

Pratesi

et al. 2024

Experimental Dermatology

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Hidradenitis suppurativa (HS) is a chronic skin disease, characterized by clinical inflammation of the hair follicle with the recurrence of abscesses, nodules, and tunnels. Recently, several studies suggested a role of IL‐1 family (IL‐1F) cytokines in eliciting and sustaining the disease. The aim of this work is to perform a comprehensive analysis of IL‐1F cytokines, soluble inhibitors and receptors in a cohort of HS patients not treated with biological agents. Sixteen patients affected by HS and 16 healthy controls were recruited; clinical data were collected and disease severity evaluated by means of the International HS Severity Score System (IHS4). Serum levels of IL‐1F cytokines, inhibitors and receptors were measured using a Multiplex Assays. IL‐18 and free IL‐18 levels were significantly higher in patients vs controls. Among soluble inhibitors, IL‐1Ra, IL‐1R2 and ST2/IL‐1R4 were significantly increased. IL‐18, free IL‐18 and IL‐33 levels are strongly correlated with IHS4. Also the inhibitors IL‐1Ra and IL‐18BP show a correlation with IHS4. The data obtained in this study confirm the involvement of IL‐1F cytokines in mediating the disease and determining its severity and suggest a possible role for IL‐18 as novel serum biomarker of active disease.

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Hidradenitis Suppurativa-Related Autoinflammatory Syndromes

Cited by 6 publications

References 114 publications

Advancements in Comorbidity Screening and Multidisciplinary Symptom Management for Hidradenitis Suppurativa

Advancements in Comorbidity Screening and Multidisciplinary Symptom Management for Hidradenitis Suppurativa

IRAK4: A Novel Target in the Therapeutic Landscape of Hidradenitis Suppurativa?

Interleukin‐1 family cytokines and soluble receptors in hidradenitis suppurativa

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