Hidradenitis suppurativa prevalence in Berekum, Ghana: A cross-sectional study and initial validation of a questionnaire in an African setting

Hagan, Paa Gyasi; Andersen, Rune Kjærsgaard; Seldam, Inge ten; Gelder, Fleur van; Zwijnenburg, Ceren; Boer, Jurr; Jemec, Gregor B E

doi:10.1016/j.jdin.2020.02.001

Cited by 15 publications

(25 citation statements)

References 5 publications

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“…[1][2][3] In Western, African and Australian populations, HS has a female : male ratio of approximately 3-4 : 1; typical onset in the third decade of life; 4,5 and a suggested prevalence rate of around 1%. [6][7][8][9] There is sparse evidence concerning HS in Asia, but it is suggested that it may be considered a predominantly male disease, with a prevalence of approximately 0Á1%. 10 HS is associated with multiple comorbidities and a significantly reduced health-related quality of life.…”

Section: What Does This Study Add?mentioning

confidence: 99%

Evidence of gene–gene interaction in hidradenitis suppurativa: a nationwide registry study of Danish twins

Andersen

Clemmensen

Larsen

et al. 2022

British Journal of Dermatology

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Summary Background Hidradenitis suppurativa (HS) is a recurrent inflammatory skin disease that, apart from rare causative loss‐of‐function mutations, has a widely unknown genetic aetiology. Objectives To estimate the relative importance of genetic and environmental factors underlying susceptibility to HS. Methods Via the Danish Twin Registry and the Danish National Patient Registry we pulled together information on zygosity with that of HS status. Cases of HS were identified by the International Classification of Diseases (ICD)‐8 (705·91) and ICD‐10 (L73·2). Heritability was assessed by the classic biometric model and the possibility of gene–gene interaction via the multilocus modelling approach. Results Among 100 044 registered twins, we found 170 twins (from 163 pairs) diagnosed with HS. The seven concordant pairs were all monozygotic. Monozygotic twins had a case‐wise concordance rate of 28% [95% confidence interval (CI) 7–49], corresponding to a familial risk of 73 (95% CI 13–133) times that of the background population. The biometrical modelling suggested a heritability of 0·80 (95% CI 0·67–0·93), and the multilocus index estimate was 230 (95% CI 60–400). This is highly indicative of gene–gene interactions, with the possibility of up to six interacting loci. Conclusions This twin study was substantially larger and employed a more valid phenotype than previous studies. Genetics account for the majority of HS susceptibility, and HS is most likely caused by gene–gene interactions rather than monogenetic mutations or solely additive genetic factors. New approaches aimed at assessing potential interactions at a single‐nucleotide polymorphism (SNP)–SNP level should be implemented in future HS genome‐wide association studies.

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Section: What Does This Study Add?mentioning

confidence: 99%

Evidence of gene–gene interaction in hidradenitis suppurativa: a nationwide registry study of Danish twins

Andersen

Clemmensen

Larsen

et al. 2022

British Journal of Dermatology

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“…We attempted to estimate the prevalence of HS in Singapore and assessed the knowledge and perceptions towards HS in this cross-sectional study following a previously described methodology involving a screening questionnaire followed by dermatologist validation. 5,6 1025 surveys were administered between April and July 2021 (response rate: 61% of 1680 patients approached) to consecutive outpatients attending non-dermatology clinics on the same hospital floor. A screening question consisted of whether the participant ever had typical lesions of HS.…”

Section: Prevalence and Perceptions Towards Hidradenitis Suppurativa:...mentioning

confidence: 99%

Prevalence and perceptions towards hidradenitis suppurativa: a cross‐sectional study in a non‐dermatological outpatient population

Han

Choi

Nagad

et al. 2022

Acad Dermatol Venereol

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and will be provided following review and approval of a research proposal and statistical analysis plan and execution of a data-sharing agreement. Data requests can be submitted at any time, and the data will be accessible for 12 months, with possible extensions considered. For more information on the process, or to submit a request, visit the following link: https://www.abbvie.com/our-science/clinical-trials/clinical-trialsdata-and-information-sharing/data-and-information-sharingwith-qualified-researchers.html.

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“…12 Data for Africa are currently limited; however, a recent questionnaire study conducted in Ghana found a prevalence of 0Á8%. 13…”

Section: Prevalencementioning

confidence: 99%

The epidemiology of hidradenitis suppurativa*

Ingram¹

2020

Br. J. Dermatol.

112

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Summary Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease defined clinically by multiple, painful inflammatory lesions occurring predominantly in flexural sites. Onset is typically soon after puberty; however, it remains unknown whether the menopause induces remission. In North American and European patients with HS the female‐to‐male ratio is approximately 3 : 1 but the ratio is 1 : 2 in South Korean patients. It may be that some elements of HS epidemiology cannot be generalized across all populations. Elements of HS epidemiology in the USA and Europe are well established, including strong associations with obesity and smoking, which may increase disease severity. There are associations between HS and other cardiovascular disease (CVD) risk factors, including type 2 diabetes and metabolic syndrome. People with HS have double the risk of death from CVD compared with those without HS and 1·5 times the risk compared with patients with psoriasis. Depression and anxiety are associated with HS and completed suicide rates in those with HS are more than double the rates in controls. Associations exist between HS and other chronic inflammatory conditions, particularly inflammatory bowel disease and inflammatory arthritis. Case–control studies demonstrate associations with pilonidal sinus, polycystic ovary syndrome, Down syndrome, obstructive sleep apnoea and pyoderma gangrenosum. Population‐based studies using routinely collected healthcare data from the USA estimate a prevalence of 0·1%, suggesting HS is relatively uncommon. European studies include undiagnosed patients and typically estimate prevalence of 1% or more, suggesting a common condition. Resolving the controversy surrounding a greater than 10‐fold difference in HS prevalence estimates remains a high priority.

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Hidradenitis suppurativa prevalence in Berekum, Ghana: A cross-sectional study and initial validation of a questionnaire in an African setting

Cited by 15 publications

References 5 publications

Evidence of gene–gene interaction in hidradenitis suppurativa: a nationwide registry study of Danish twins

Evidence of gene–gene interaction in hidradenitis suppurativa: a nationwide registry study of Danish twins

Prevalence and perceptions towards hidradenitis suppurativa: a cross‐sectional study in a non‐dermatological outpatient population

The epidemiology of hidradenitis suppurativa*

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