Hidradenitis Suppurativa

éno, Brigitte Dr; Khammari, Amir; Brocard, Anabelle; Moyse, Dominique; Blouin, Eric; Guillet, G.; éonard, Fabienne L; Knol, Anne-Chantal

doi:10.1001/archdermatol.2011.315

Cited by 109 publications

(42 citation statements)

References 22 publications

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“…Treatment with zinc induces a significant increase in the expression of all the markers involved in innate immunity [28]. Recent studies have shown that Toll-like receptor- (TLR-) 2 expression, a receptor of the innate immune system, was increased in acne lesions and could play an essential role in acne-linked inflammation.…”

Section: Discussionmentioning

confidence: 99%

Correlation between the Severity and Type of Acne Lesions with Serum Zinc Levels in Patients with Acne Vulgaris

Mogaddam

Ardabili

Maleki

et al. 2014

BioMed Research International

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Acne vulgaris is the most common cutaneous disorder affecting adolescents and young adults. Some studies have reported an association between serum zinc levels and acne vulgaris. We aimed to evaluate the serum zinc level in patients with acne vulgaris and compare it with healthy controls. One hundred patients with acne vulgaris and 100 healthy controls were referred to our clinic. Acne severity was classified according to Global Acne Grading System (GAGS). Atomic absorption spectrophotometry was used to measure serum zinc levels. Mean serum level of zinc in acne patients and controls was 81.31 ± 17.63 μg/dl and 82.63 ± 17.49 μg/dl, respectively. Although the mean serum zinc level was lower in acne group, it was not statistically significant (P = 0.598). There was a correlation between serum zinc levels with severity and type of acne lesions. The results of our study suggest that zinc levels may be related to the severity and type of acne lesions in patients with acne vulgaris. Relative decrease of serum zinc level in acne patients suggests a role for zinc in the pathogenesis of acne vulgaris.

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Section: Discussionmentioning

confidence: 99%

Correlation between the Severity and Type of Acne Lesions with Serum Zinc Levels in Patients with Acne Vulgaris

Mogaddam

Ardabili

Maleki

et al. 2014

BioMed Research International

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“…Histopathological studies suggest HS patients have a defect of keratinocyte shedding resulting in blockage of the hair follicle, buildup of secretions in the apocrine glands and secondary infection (Danby, Jemec et al 2013). Abnormalities in keratinocyte antimicrobial peptide production may additionally contribute to defective keratinocyte function and impaired microbial clearance seen with this disease (Bechara, Sand et al 2012, Dreno, Khammari et al 2012, Emelianov, Bechara et al 2012, Hofmann, Saborowski et al 2012). While antibiotics are widely used to control symptoms in HS, they do not treat the underlying cause of the disease (Yazdanyar and Jemec 2011).…”

Section: Introductionmentioning

confidence: 99%

Interferon-gamma (IFN-γ) is Elevated in Wound Exudate from Hidradenitis Suppurativa

Banerjee

McNish

Shanmugam

2016

Immunological Investigations

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Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory disease of apocrine glands which affects 1% to 4% of young adults. The purpose of this study was to investigate inflammatory cytokines in effluent from HS lesions and to identify potential local drivers of inflammation in HS. Wound fluid specimens from HS patients (n=8) and age-matched chronic wound patients (n=8) were selected for analysis. The Hidradenitis Suppurativa Score (HSS) was used to determine extent of HS activity. Cytokine analysis was conducted using Meso Scale Discovery cytokine and proinflammatory panels. Interferon-gamma (IFN-γ) was significantly elevated in the HS effluent compared to chronic wounds (1418 ± 1501 pg/ml compared to 102.5 ± 138 pg/ml, p 0.027). HS effluent also had significantly higher levels of TNF-β (9.24 ± 7.22 pg/ml compared to 1.65 ± 2.14 pg/ml, p 0.03). There was no significant difference in any other cytokines. There was no significant difference in demographics in the HS compared to chronic wound cohorts. Mean HSS in the HS cohort was 68.88 (SD ± 41.45). In this proof of concept pilot study, IFN- γ was significantly elevated in HS effluent. TNF-β/LT-α levels were also elevated in HS, although the levels were more modest. Further studies should focus on molecular drivers of tissue injury in HS, and the relationship between HS effluent cytokine profile and disease activity.

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“…A reduction in natural killer cells, an increased production of free oxygen radicals by neutrophils, an increase in inflammatory cytokines, an enhanced expression of toll-like receptor 2 in macrophages and dendritic cells, and an aberrant expression of antimicrobial peptides have all been incriminated in its pathogenesis 2, 5, 6, 7. High-dose radiation therapy (RT), which is used for the treatment of endometrial adenocarcinoma, can lead to the local production of proinflammatory anaphylatoxins C3a and C5a, to the influx of immune cells in skin, to an increase in apoptosis, and to an increase in the generation of free radicals, providing a hypothesis to the potential mechanism responsible 8 .…”

Section: Discussionmentioning

confidence: 99%

Radiation-induced hidradenitis suppurativa: A case report

et al. 2017

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Hidradenitis Suppurativa

Abstract: To evaluate the expression of innate immunity markers at the site of nodules caused by hidradenitis suppurativa (HS).Design: Prospective analysis of 12 patients with HS.

Cited by 109 publications

References 22 publications

Correlation between the Severity and Type of Acne Lesions with Serum Zinc Levels in Patients with Acne Vulgaris

Correlation between the Severity and Type of Acne Lesions with Serum Zinc Levels in Patients with Acne Vulgaris

Interferon-gamma (IFN-γ) is Elevated in Wound Exudate from Hidradenitis Suppurativa

Radiation-induced hidradenitis suppurativa: A case report

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