Hidradenitis Suppurativa–Like Condition Occurring After Microwave Sweat Gland Ablation

Huang, Amy; Lindgren, Aleksandra; Krempa, Mary; Hui, Andrea

doi:10.1097/dss.0000000000001457

Cited by 4 publications

(5 citation statements)

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“…Another patient developed pain, erythema, and swelling in the right axilla within 1 month of treatment, with subsequent scarring and sinus tracts at 5 months. The patient's disease was refractory to cephalexin and intralesional triamcinolone and ultimately required excision of sinus tracts that led to cessation of symptoms 17 …”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, two cases of MED-induced HS were reported. 16,17 Study authors posited that fibrosis of periglandular areas and subsequent reactive inflammatory infiltrates may have altered the infundibular anatomy to resemble a state similar to the pathophysiology of HS. 16 Another hypothesis was that a patient may have had undiagnosed epidermal cysts that ruptured during treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Study authors posited that fibrosis of periglandular areas and subsequent reactive inflammatory infiltrates may have altered the infundibular anatomy to resemble a state similar to the pathophysiology of HS 16 . Another hypothesis was that a patient may have had undiagnosed epidermal cysts that ruptured during treatment 17 . These studies question the role of microwave ablative therapy in HS patients and warn of its potential to worsen disease.…”

Section: Discussionmentioning

confidence: 99%

“…An RCT was discontinued due to significant adverse effects and worsening of HS disease. Furthermore, two cases of MED‐induced HS were reported 16,17 . Study authors posited that fibrosis of periglandular areas and subsequent reactive inflammatory infiltrates may have altered the infundibular anatomy to resemble a state similar to the pathophysiology of HS 16 .…”

Section: Discussionmentioning

confidence: 99%

“…16 Another hypothesis was that a patient may have had undiagnosed epidermal cysts that ruptured during treatment. 17 These studies question the role of microwave ablative therapy in HS patients and warn of its potential to worsen disease.…”

Section: Discussionmentioning

confidence: 99%

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Hyperhidrosis treatments in hidradenitis suppurativa: A systematic review

Shih

Lee

Seivright

et al. 2021

Dermatologic Therapy

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Hyperhidrosis impairs quality of life (QOL) in hidradenitis suppurativa (HS) patients and may exacerbate HS. However, there is limited literature on whether hyperhidrosis treatments improve HS disease. To systematically review literature on efficacy and tolerability of hyperhidrosis treatments in HS patients. In May 2021, MEDLINE and EMBASE databases were systematically searched by two reviewers per PRISMA guidelines for articles on hyperhidrosis and HS. Sixteen articles met inclusion criteria (2 randomized controlled trials [RCTs], one case-control study, three cross-sectional studies, 10 case-studies/ series), encompassing 252 HS patients across studies. They examined botulinum toxin A (BTX-A) (n = 6) and B (BTX-B) (n = 1), suction-curettage (n = 1), diode laser (n = 1), and microwave-based energy device (MED) (n = 3). Overall, BTX treatments improve HS severity, QOL, hyperhidrosis, and were well-tolerated. Suction-curettage did not improve disease. One HS patient tolerated diode laser well, with improvement in sweating and HS. One RCT studying MED was discontinued due to adverse events. Two studies reported MED-induced HS. BTX was overall helpful in HS patients, including in patients without concomitant hyperhidrosis. However, more prospective studies are needed to examine its utility in HS. There is potential harm of MEDs in HS. Most studies examining hyperhidrosis treatments in HS patients are low level of evidence. Larger RCTs should examine the efficacy and tolerability of hyperhidrosis treatments in HS.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%