Hidradenitis Suppurativa Disproportionately Affects African Americans: A Single-center Retrospective Analysis

Vlassova, Natalia; Kuhn, Diane; Okoye, Ginette A.

doi:10.2340/00015555-2176

Cited by 63 publications

(70 citation statements)

References 7 publications

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“…1,2,5,9-14 This data justifies its late diagnosis and in more advanced stages, as found in our study, with a mean time of 9 years for diagnosis and most patients presenting Hurley stage II or III.…”

Section: Discussionsupporting

confidence: 86%

“…1-7 It is characterized by recurrent nodules, bridge scars and suppuration in intertriginous areas. 1,2,8,9 The disease severely affects patients' quality of life.…”

Section: Introductionmentioning

confidence: 99%

“…1-7 It is characterized by recurrent nodules, bridge scars and suppuration in intertriginous areas. 1,2,8,9 The disease severely affects patients' quality of life. 1,9 When associated with acne conglobata, pilonidal cysts and dissecting cellulitis of the scalp, the syndrome is defined as a tetrad of follicular occlusion.…”

Section: Introductionmentioning

confidence: 99%

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Hidradenitis suppurativa: epidemiological study of cases diagnosed at a dermatological reference center in the city of Bauru, in the Brazilian southeast State of São Paulo, between 2005 and 2015

Andrade

Vieira

Oliveira

et al. 2017

An. Bras. Dermatol.

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BackgroundHidradenitis is a chronic inflammatory disease of the hair follicles. A treatment is necessary due to chronicity and psychological changes that patient present.ObjectiveTo investigate epidemiological aspects and elaborate a risk group profile, promote early diagnosis and contribute to the knowledge about the disease.MethodsThis cross-sectional descriptive study with retrospective analysis of medical records of 194 patients diagnosed with hidrosadenitis in a dermatological reference center in the city of Bauru (SP) between 2005 and 2015.ResultsFemales accounted for 74% of cases. The age at diagnosis ranged from 10 to 67 years and the majority was within the 3rd and 4th decade of life. It occurred Association with diabetes mellitus in 33%, obesity in 55% and smoking in 61% was observed. Mean time between the onset of the disease and diagnosis was nine years. Hurley stage II was the most common at diagnosis. The therapeutic option mostly used in Hurley I and II was systemic antibiotics and in Hurley III was surgery.Study limitationsthe main limitation of this study is its retrospective design, which does not allow the true clinical confirmation of the disease by investigators.Conclusionwe outlined the following profile: women, caucasian, between 3rd and 4th decade of life, associated with obesity, smoking, late diagnosis and multiple potential therapeutic modalities. We highlight the importance of studies like this in order to identify risk groups and encourage early diagnosis.

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Section: Discussionsupporting

confidence: 86%

“…1-7 It is characterized by recurrent nodules, bridge scars and suppuration in intertriginous areas. 1,2,8,9 The disease severely affects patients' quality of life.…”

Section: Introductionmentioning

confidence: 99%

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Hidradenitis suppurativa: epidemiological study of cases diagnosed at a dermatological reference center in the city of Bauru, in the Brazilian southeast State of São Paulo, between 2005 and 2015

Andrade

Vieira

Oliveira

et al. 2017

An. Bras. Dermatol.

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“…A Danish trial did not report race for any participants [36]. Two trials did have cohorts containing 19–20% AA; however, this still contrasts with results from studies reporting that AA make up to 65% of patients with HS in the USA, have a 1-year incidence of HS more than double that of Caucasians, and have the highest 1-year incidence of HS across all age groups [4, 5, 34, 35]. Furthermore, none of the trials reported the percentage of patients that were Hispanic or stratified the responses to adalimumab by race.…”

Section: Treatment Response In Socmentioning

confidence: 71%

“…Although the prevalence of HS varies (from 0.00033 to 4.1%), studies have reported an increased prevalence in African and Hispanic populations, as well as in women [4, 5]. The disease burden of HS is largely due to a profound physical and psychological impact, which leads to depression and impaired quality of life (QoL) [6, 7].…”

Section: Introductionmentioning

confidence: 99%

Hidradenitis Suppurativa: Disease Burden and Etiology in Skin of Color

2017

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Hidradenitis suppurativa (HS) is a chronic, debilitating skin disease. Although most studies on HS are conducted in largely Caucasian populations, evidence demonstrates a higher prevalence in patients with skin of color, including African and Hispanic populations. These racial subgroups are likely at risk for greater disease burden due to a higher prevalence of components of the metabolic syndrome, comorbid depression, and low socioeconomic status; however, there is a paucity of research in these populations. Additionally, studies examining the genetic and anatomical basis for HS, as well as the response to HS therapies, are lacking for patients with skin of color. Complicating this issue is the limited access to effective medical care, including dermatologists, for African and Hispanic populations as well as other minority groups. In this review, we identify gaps in the knowledge base, highlight the association between HS and patients with skin of color, and provide direction for much needed research into this condition.

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Patient Impressions and Outcomes After Clinic-Based Hidradenitis Suppurativa Surgery

et al. 2022

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idradenitis suppurativa (HS) is a chronic inflammatory skin condition consisting of painful abscesses, nodules, sinus tracts, and scarring with a predilection for intertriginous sites. 1,2 Hidradenitis suppurativa is more common in Black individuals, female individuals, and people with low socioeconomic status; onset of disease occurs most often in the third and fourth decades of life. [3][4][5][6][7] Typical medical treatment includes antibiotics, hormonal therapies, and tumor necrosis factor inhibitors, but surgery is often vital in treating recurrent nodules and tunnels. [8][9][10][11][12][13][14][15] Deroofing involves removal of overlying skin at the sites of sinuses, and the mostly dermal wound base is left to heal by secondary intention. 16 Excision removes affected skin to the subcutaneous fat with a small margin of healthy tissue. 17,18 The excised area may be left to heal by secondary intention, closed primarily, or covered by a flap or graft. Rates of reported recurrence have been similar for deroofing and excision, with rates ranging from less than 5% to 25%. [19][20][21][22][23] Few data comparing primary closure vs secondary intention healing have been reported. 24 Incision and drainage relieves acute pain from abscesses, but excision or deroofing is the definitive treatment for longstanding or recurrent sinuses. 16,19,20,25 Patient satisfaction and outcomes after HS surgery performed with general or local anesthesia have been positive in retrospective questionnaire-based studies, including studies examining excision, deroofing, and a combination of approaches. 16,[21][22][23][26][27][28] The results from these studies indicated that patients were very satisfied with the scar appear-IMPORTANCE Surgical intervention is frequently needed to treat hidradenitis suppurativa (HS). Patient satisfaction is high based on previous studies, but reports of patient impressions of clinic-based operative experiences and postoperative recovery are limited.OBJECTIVE To characterize patient impressions, outcomes, and recovery time after clinic-based surgical treatment of HS and examine patient characteristics associated with outcomes. DESIGN, SETTING, AND PARTICIPANTSThis retrospective cohort study included patients 12 years or older who underwent clinic-based surgical procedures for treatment of HS at a single subspecialty HS clinic at the

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Hidradenitis Suppurativa Disproportionately Affects African Americans: A Single-center Retrospective Analysis

Cited by 63 publications

References 7 publications

Hidradenitis suppurativa: epidemiological study of cases diagnosed at a dermatological reference center in the city of Bauru, in the Brazilian southeast State of São Paulo, between 2005 and 2015

Hidradenitis suppurativa: epidemiological study of cases diagnosed at a dermatological reference center in the city of Bauru, in the Brazilian southeast State of São Paulo, between 2005 and 2015

Hidradenitis Suppurativa: Disease Burden and Etiology in Skin of Color

Patient Impressions and Outcomes After Clinic-Based Hidradenitis Suppurativa Surgery

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