Hidradénite eccrine neutrophilique idiopathique de l’adulte d’évolution prolongée traitée par colchicine

Belot, Véronique; Perrinaud, A.; Corven, C.; Muret, A. De; Lorette, G; Machet, L.

doi:10.1016/s0755-4982(06)74837-0

Cited by 18 publications

(9 citation statements)

References 13 publications

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“…Adults with idiopathic NEH have been described rarely and without elucidation of their initial symptoms and clinical characteristics. 7 In our study, adults with idiopathic NEH were younger and slightly more likely to be female vs. adults with malignancy-associated NEH, and their skin eruptions were limited to the palmoplantar area, as for the pediatric patients. However, the course of the disease in idiopathic NEH had more frequent recurrences, necessitating systemic therapy such as colchicine, whereas most malignancy-and chemotherapy-associated NEH cases responded well to conservative therapy and did not recur after cessation of chemotherapy.…”

Section: Discussionmentioning

confidence: 57%

“…In this retrospective study of 33 patients with NEH, the most common association was AML with chemotherapy, whereas five of 21 adults (24%) had idiopathic NEH. Adults with idiopathic NEH have been described rarely and without elucidation of their initial symptoms and clinical characteristics 7 . In our study, adults with idiopathic NEH were younger and slightly more likely to be female vs. adults with malignancy‐associated NEH, and their skin eruptions were limited to the palmoplantar area, as for the pediatric patients.…”

Section: Discussionmentioning

confidence: 63%

“…Our study findings showed that 80% of adults with idiopathic NEH required active intervention, and many responded to systemic colchicine therapy. Of note, previous studies of pediatric patients have found colchicine to be effective for idiopathic NEH in children 7,8 …”

Section: Discussionmentioning

confidence: 94%

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Neutrophilic eccrine hidradenitis: a retrospective study

et al. 2023

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BackgroundNeutrophilic eccrine hidradenitis (NEH) is a benign neutrophilic dermatosis not well recognized beyond an association with malignancy. Although the disease is commonly reported in adults with malignancy, this association is uncommon in children. The diagnosis of NEH is predominantly based on histologic findings to exclude alternative diagnoses for adults, but biopsy is not usually required for children.MethodsA retrospective study was performed of adult and pediatric patients diagnosed with NEH at three Mayo Clinic sites from January 1, 1992, to January 1, 2022. The aim of this study was to elucidate risk factors for NEH and its clinical characteristics, treatment options, and natural course. Clinical information and pathologic results were collected from health records. Available pathologic slides were reviewed with a dermatopathologist.ResultsOf 47 patients identified, 33 had either histologic or clinical confirmation of the diagnosis; 21 were adults (64%), and 12 were children (36%). Most adults (16/21; 76%) had underlying malignancy and received chemotherapy. Five adults (24%) were classified as having idiopathic NEH, and they were younger and had higher NEH recurrence rates than the other adults. Only one pediatric patient (8%) had underlying malignancy. For 10 children (83%), NEH was preceded by strenuous activity. Initial findings of idiopathic NEH were palmoplantar eruptions for both adult and pediatric patients, whereas malignancy‐associated NEH commonly involved the face and axillae.ConclusionsAmong adults, NEH is commonly associated with malignancy and chemotherapy. Among children, idiopathic NEH occurs primarily after overexertion, and malignancy is highly unlikely to be the cause of NEH.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 63%

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Neutrophilic eccrine hidradenitis: a retrospective study

et al. 2023

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“…As mentioned, NEH has been described in a healthy population as well [10]. Therefore, a theory regarding possible sweat gland abnormalities was formulated [4].…”

Section: Discussionmentioning

confidence: 99%

“…Pain should be managed with usual analgesic medication if tender lesions are present. One study in a healthy patient reports colchicine use with improvement after 1 month [10]. As for the prevention of possible recurrences of NEH with the same drug use, one case report encourages dapsone use, which has specific effects on neutrophil migration, with a dosage of 100 mg daily for 48 h before the treatment [11].…”

Section: Discussionmentioning

confidence: 99%

A Classic Clinical Case: Neutrophilic Eccrine Hidradenitis

Copaescu¹,

Castilloux

Chababi-Atallah³

et al. 2013

Case Rep Dermatol

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Background: Neutrophilic eccrine hidradenitis (NEH) is a rare condition described mostly in adult patients receiving chemotherapy for acute myelogenous leukemia. When it affects the facial region, it can mimic cellulitis and delay the diagnostic, thus proper recognition is essential. Objective: This article describes a classic case of NEH. We will review the diagnostic, the differential diagnostic (mostly cellulitis) and the management of this condition. Methods: After a literature review, the patient's file was properly studied in order to portray a clear picture of this condition. Medical photographs and appropriate physical examination upon presentation are also included. Results: The diagnostic for NEH was suggested by the clinical presentation and confirmed histopathologically (skin biopsy). Conclusion: The diagnostic of NEH is essential in order to prevent multiple unnecessary antibiotics.

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