Hide powder and collagen lysis by organisms from the oral cavity

Roth, Genevieve D.; Myers, Hugh I.

doi:10.1016/0030-4220(56)90187-6

Cited by 20 publications

(5 citation statements)

References 10 publications

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“…The discrepancy between these results and those previously reported ( 3 ) can be explained by the fact that the collagen becomes susceptible to proteases of the gingival microbiota when frozen, thawed, and sterilized by ethylene oxide, as in the prior study. After 6 weeks' incubation, 3 of 5 additional tests showed only slight collagenolysis.…”

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confidence: 87%

Resistance of Human Gingival Collagen to Human Gingival Bacteria.

Thonard

Scherp

1957

Experimental Biology and Medicine

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165against attaining a high concentration in the skin. Topical application would also appear to be an unreliable approach to the epidermis especially in the case of human skin lesions since the conditions of interest present an unusually thick keratin barrier. Furthermore, the absence of sebaceous glands in plantar skin would almost preclude penetration of vit. A a t this most common site of verrucae and other hyperkeratoses since the sebaceous glands form the normal pathway for absorption of the vitamin. Intraepidermal injection of vit. A is, of course, a practical impossibility, so that, intracutaneous injection would appear to be the only efficient method of introducing vit. A at the site of an epidermal lesion.There seems to be only one possible interpretation for the results here reported. The presence of large (hence young appearing) nuclei in the basal and spinous cell layers of the epidermis coupled with a normal rate of mitosis, indicates that the physiologic sequence of maturation and death of these cells has been slowed. Therefore, cells of all types have accumulated and less keratin has been laid down. If these changes occur also in human skin it is reasonable to suppose that injection of vit. A at the site of an heloma would reverse the pathologic process since this lesion shows a central area of atrophy of the epidermis with an overlying plug of horny material. The mechanism of action in the case of verruca, a proliferative virus disease, is still obscure and future work will be directed toward its clarification.Summary. It has been found that a single intracutaneous injection of vit. A in the rabbit causes an increase in thickness of the epidermis (excluding corneum) which is due to an increase in both number and size of the cells in the germinative and granular layers. The corneum becomes thinner and denser. The occurrence of large, young appearing nuclei in the absence of an increase in mitotic rate indicates that the maturation process is slowed.

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contrasting

confidence: 87%

Resistance of Human Gingival Collagen to Human Gingival Bacteria.

Thonard

Scherp

1957

Experimental Biology and Medicine

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“…' Tested on albumin-TSA agar. f Tested on albumin-mineral base agar (MBA).VOL 16,. 1982 on September 21, 2020 by guest http://jcm.asm.org/ Downloaded from…”

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confidence: 99%

Enzymatic profile of Pseudomonas maltophilia

O’Brien¹,

Davis²

1982

J Clin Microbiol

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An enzymatic profile of 20 strains of Pseuidomonas maltophilia was undertaken with conventional plate tests, API ZYM, and 4-methylumbelliferyl-conjugated substrates. All strains produced DNase, RNase, arbutinase, esterases and lipases, mucinase, acid and alkaline phosphatases, alkaline pyrophosphate diesterase, phosphoamidase, 3-glucosidase, leucine arylamidase, and acetatase and were hemolytic for horse, sheep, and rabbit blood. The majority of strains produced chitinase, hyaluronidase, albuminase, valine arylamidase, trypsin, cxand 1glucosidases, and N-acetyl-1-glucosaminidase. API ZYM and 4-methylumbelliferyl-conjugated substrate assays are rapid, simple, specific, and sensitive and may be useful as diagnostic aids in the identification of P. maltophilia and other pseudomonads.

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“…It is well known that certain Clostridiuni species produce proteolytic enzymes capable of hydrolyzing native collagen, but apparently other bacteria possessing such enzymes have not been reported. Organisms with this capacity have been sought unsuccessfully in traumatic wounds (MacLennen, Mandl, and Howes, 1953), among salt tolerant bacteria (Everett and Cordon 1955), and in the oral cavity of man (Roth and Meyers, 1956;Schultz-Haudt and Scherp, 1955;Mergenhagen and Scherp, 1960). It has seemed likely that collagenolytic organisms are among the members of the oral microbiota since collagen degradation is a feature of both dentinal caries (Engel, 1950) and periodontal disease (Lucas and Thonard, 1955).…”

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confidence: 99%