Hidden Urban Geographies: The Case of Barcelona

Danaparoid Sodium: A Review of Its Use in Hepatic Thrombotic Disorders

“…SOS usually manifests within 21 days but may present late, with thrombocytopenia and signs of portal hypertension due to fibrous obliteration of the sinusoids and central venules. Endothelial injury underlies both disorders but for some [21] this is insufficient to consider SOS as a vascular endothelial syndrome. However, others [22] disagree since TA-TMA, with its mixed endothelial/immune origin is included [21].…”

“…Endothelial injury underlies both disorders but for some [21] this is insufficient to consider SOS as a vascular endothelial syndrome. However, others [22] disagree since TA-TMA, with its mixed endothelial/immune origin is included [21]. Furthermore, immunological involvement in the pathogenesis of SOS is also very likely since injured ECs release cytokines and mitogens and these are capable of complement cascade activation and disruption [23].…”

“…Perhaps TA-TMA represents a vascular form of GvHD since it may precede the appearance of GvHD and its frequency increases with the severity of GvHD [21] and they share similarities in pathophysiology [27][28][29]. These considerations may explain the overlaps and differences between SOS and TA-TMA in their risk factors (see Table 1) and their distribution, clinical presentation and sequelae (see Table 2).…”