“…Indeed, the CNS, as an immunologically privileged site (see below), is an organ in which RNA viruses can often establish persistent infections with disease consequences [5,19]. Recent examples include reactivation of CNS infection after apparent recovery from Ebola virus disease [14,20]. Other chronic human diseases have also been linked to persistent RNA virus infections, some controversially, include Paget's bone disease, multiple sclerosis, otosclerosis, postpolio syndrome and other late neurodegenerative diseases, chronic fatigue syndrome, certain autoimmune diseases and exacerbation of chronic obstructive pulmonary disease.…”