Hidden Peptides Encoded by Putative Noncoding RNAs

Matsumoto, Akinobu; Nakayama, Keiichi I.

doi:10.1247/csf.18005

Cited by 51 publications

(45 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, they were always ignored [24]. However, as proteomics and translation technology have grown in popularity and increased in precision and accuracy, it was discovered that many ncRNAs are translatable [13,[25][26][27][28]. At present, it is recognized that long ncRNAs (lncRNAs) and circular RNAs (circRNAs) contain sORFs that can be translated into functional small peptides.…”

Section: Introductionmentioning

confidence: 99%

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

et al. 2020

View full text Add to dashboard Cite

Non-coding RNAs do not encode proteins and regulate various oncological processes. They are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics and translation omics have begun to elucidate the roles and modes of action of the functional peptides encoded by ncRNA. Here, recent advances in long non-coding RNA (lncRNA) and circular RNA (circRNA)-encoded small peptides are compiled and synthesized. We introduce both the computational and analytical methods used to forecast prospective ncRNAs encoding oncologically functional oligopeptides. We also present numerous specific lncRNA and circRNA-encoded proteins and their cancer-promoting or cancer-inhibiting molecular mechanisms. This information may expedite the discovery, development, and optimization of novel and efficacious cancer diagnostic, therapeutic, and prognostic protein-based tools derived from non-coding RNAs. The role of ncRNA-encoding functional peptides has promising application perspectives and potential challenges in cancer research. The aim of this review is to provide a theoretical basis and relevant references, which may promote the discovery of more functional peptides encoded by ncRNAs, and further develop novel anticancer therapeutic targets, as well as diagnostic and prognostic cancer markers.

show abstract

Section: Introductionmentioning

confidence: 99%

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Circular RNAs (CircRNAs) are a class of non-coding RNAs which constructed by a closed loop with no protein coding potential [4][5][6]. CircRNAs have been recognized as imperative regulators in multiple physiological/pathological processes.…”

Section: Introductionmentioning

confidence: 99%

Increased Expression of Circular RNA circ_0005230 Indicates Dismal Prognosis in Breast Cancer and Regulates Cell Proliferation and Invasion via miR-618/ CBX8 Signal Pathway

Yao

Leng

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Circular RNAs (circRNAs) are a class of non-coding RNAs. They have been proved to be critically involved in tumorigenesis and progression of malignancies through competing endogenous RNA (ceRNA) mechanism. Nevertheless, the exploration between circRNAs and pathogenesis of breast cancer (BC) is limited. Previously, circ_0005230 was identified upregulated in BC tissues screened by circRNA microarray. In the present study, we aimed to investigate the expression pattern, functional role, and mechanism of circ_0005230 in BC. Methods: qRT-PCR was conducted to elucidate the expression levels of circ_0005230 in BC tissues and cells. Additionally, the clinical severity and prognostic value were investigated. CCK-8, colony-forming, flow cytometric assays were performed. Animal study was conducted to validate the in vitro data. What’s more, Transwell assays were induced to detect the cell metastatic properties of circ_0005230 exerts in BC cells. Luciferase reporter assay was used to measure the mechanism of circ_0005230. Results: circ_0005230 was overexpressed in BC tissue specimens and cell lines. The overexpression of circ_0005230 was related to adverse phenotypes in the patients with BC. In addition, circ_0005230 could be regarded as a prognostic predictor in BC patients. In vitro and in vivo data demonstrated the cell growth promoting role of circ_0005230. Moreover, circ_0005230 could also promote cell migratory and invasive capacities. For the mechanism investigation, circ_0005230 was proved to be a sponge of miR-618, and expression of miR-618 could regulate CBX8 expression via targeting the 3’UTR of CBX8. Rescue assays also illustrated an oncogenic function of circ_0005230 in BC via acting as a miR-618 sponge to promote CBX8 expression. Conclusion: circ_0005230/miR-618/CBX8 axis might play a key role in BC tumorigenesis and development.

show abstract

“…This means that lncRNAs do not encode proteins, i.e., they do not harbor an open reading frame. However, recent studies have revealed that a subset of lncRNAs that code small peptides, usually shorter than 100 amino acids, exists [179][180][181]. These lnRNAs are localized in the cytosol and contain only a single-exon-sequence coding peptide.…”

Section: Peptides-a New Factor In the Lncrna Interactome?mentioning

confidence: 99%

Human Long Noncoding RNA Interactome: Detection, Characterization and Function

Kazimierczyk

Kasprowicz

Kasprzyk

et al. 2020

IJMS

137

102

View full text Add to dashboard Cite

The application of a new generation of sequencing techniques has revealed that most of the genome has already been transcribed. However, only a small part of the genome codes proteins. The rest of the genome "dark matter” belongs to divergent groups of non-coding RNA (ncRNA), that is not translated into proteins. There are two groups of ncRNAs, which include small and long non-coding RNAs (sncRNA and lncRNA respectively). Over the last decade, there has been an increased interest in lncRNAs and their interaction with cellular components. In this review, we presented the newest information about the human lncRNA interactome. The term lncRNA interactome refers to cellular biomolecules, such as nucleic acids, proteins, and peptides that interact with lncRNA. The lncRNA interactome was characterized in the last decade, however, understanding what role the biomolecules associated with lncRNA play and the nature of these interactions will allow us to better understand lncRNA's biological functions in the cell. We also describe a set of methods currently used for the detection of lncRNA interactome components and the analysis of their interactions. We think that such a holistic and integrated analysis of the lncRNA interactome will help to better understand its potential role in the development of organisms and cancers.

show abstract

Hidden Peptides Encoded by Putative Noncoding RNAs

Cited by 51 publications

References 38 publications

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

Increased Expression of Circular RNA circ_0005230 Indicates Dismal Prognosis in Breast Cancer and Regulates Cell Proliferation and Invasion via miR-618/ CBX8 Signal Pathway

Human Long Noncoding RNA Interactome: Detection, Characterization and Function

Contact Info

Product

Resources

About