Hidden Comorbidities in Asthma: A Perspective for a Personalized Approach

Maule, Matteo; Olivieri, Bianca; Guarnieri, Gabriella; Franceschi, Lucia De; Martinelli, Nicola; Vaia, Rachele; Argentino, Giuseppe; Vianello, Andrea; Senna, Gianenrico; Caminati, Marco

doi:10.3390/jcm12062294

Cited by 3 publications

(2 citation statements)

References 147 publications

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“…Asthma is often associated with various comorbidities which can worsen asthma symptoms and affect asthma severity [23]. For patients with asthma, comorbid conditions lead to an enhanced disease burden and, consequently, a reduced QoL [24]. The involvement of other disorders is likely to lead to polypharmacy, which can negatively impact treatment adherence and asthma control [25,26] Additionally, comorbid conditions complicate the diagnosis and management of asthmatic patients and carry a considerable economic cost [23].…”

Section: Discussionmentioning

confidence: 99%

Obese Asthma Phenotype Is Associated with hsa-miR-26a-1-3p and hsa-miR-376a-3p Modulating the IGF Axis

Gil-Martínez

Lorente-Sorolla

Rodrigo‐Muñoz

et al. 2023

IJMS

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Clarifying inflammatory processes and categorising asthma into phenotypes and endotypes improves asthma management. Obesity worsens severe asthma and reduces quality of life, although its specific molecular impact remains unclear. We previously demonstrated that hsa-miR-26a-1-3p and hsa-miR-376a-3p, biomarkers related to an inflammatory profile, discriminate eosinophilic from non-eosinophilic asthmatics. We aimed to study hsa-miR-26a-1-3p, hsa-miR-376a-3p, and their target genes in asthmatic subjects with or without obesity to find biomarkers and comprehend obese asthma mechanisms. Lung tissue samples were obtained from asthmatic patients (n = 16) and healthy subjects (n = 20). We measured miRNA expression using RT-qPCR and protein levels (IGF axis) by ELISA in confirmation samples from eosinophilic (n = 38) and non-eosinophilic (n = 39) obese (n = 26) and non-obese (n = 51) asthma patients. Asthmatic lungs showed higher hsa-miR-26a-1-3p and hsa-miR-376a-3p expression than healthy lungs. A study of seven genes regulated by these miRNAs revealed differential expression of IGFBP3 between asthma patients and healthy individuals. In obese asthma patients, we found higher hsa-miR-26a-1-3p and IGF-1R values and lower values for hsa-miR-376a-3p and IGFBP-3. Hsa-miR-26a-1-3p and IGFBP-3 were directly and inversely correlated with body mass index, respectively. Hsa-miR-26a-1-3p and hsa-miR-376a-3p could be used as biomarkers to phenotype patients with eosinophilic and non-eosinophilic asthma in relation to comorbid obesity.

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Section: Discussionmentioning

confidence: 99%

Obese Asthma Phenotype Is Associated with hsa-miR-26a-1-3p and hsa-miR-376a-3p Modulating the IGF Axis

Gil-Martínez

Lorente-Sorolla

Rodrigo‐Muñoz

et al. 2023

IJMS

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“…Allergic bronchopulmonary aspergillosis (ABPA) is traditionally included among asthma comorbidities, especially in the case of severe asthma phenotypes. In fact, in addition to cystic fibrosis, asthma represents the most relevant predisposing condition to ABPA, which substantially contributes to asthma burden [3].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of the relationship between allergic bronchopulmonary aspergillosis and asthma

Maule,

Vitte,

Ambrosani

et al. 2024

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review Allergic bronchopulmonary aspergillosis (ABPA) can complicate the natural history of asthmatic patients, especially the more severe ones, worsening disease control and increasing the need for therapies, steroids in particular, and medical care. The aim of the present review is to summarize the latest epidemiological data related to the relationship between asthma and ABPA and to offer a summary of the most recent strategies that could potentially facilitate in the identification of ABPA in asthmatic patients. Recent findings In the last years, great efforts have been made by researchers worldwide to provide reliable epidemiological data on fungal sensitization and ABPA, especially in severe asthma patients both in adult and pediatric population. Data differ depending on the geographical area and population studied, but pooled data show a concerning 11% of severe asthma patients having ABPA and one out of four asthmatic patients being sensitized to fungi, Aspergillus fumigatus in particular. Summary Reliable epidemiological data and advances in the diagnostic procedures can facilitate the detection of ABPA among asthmatic patients, improving the management of a still under-recognized and challenging condition.

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Shaping the Future in Rare Lung Diseases: From Imaging to Patient Management

Humphry

2023

EMJ Respir

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This symposium was held during the 2023 European Respiratory Society (ERS) International Congress in Milan, Italy. The main objective was to discuss unmet needs in the diagnosis and management of rare lung diseases, with a particular emphasis on alpha 1 antitrypsin deficiency (AATD) and idiopathic pulmonary fibrosis (IPF). Presentations focused on promising approaches to meet these needs, including the feasibility of genomic diagnosis, the development of improved biomarkers of disease progression, such as quantitative CT and novel blood biomarkers, the use of digital lung auscultation, and increased screening for AATD in vulnerable populations. The overarching message from the symposium was that advancements in technology, multidisciplinary collaboration, and partnerships between academic institutions, patient associations, and industry are crucial to the continued improvement of patient management in rare diseases, and that the education of healthcare professionals is vital to enhance the understanding and awareness of these conditions.

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Hidden Comorbidities in Asthma: A Perspective for a Personalized Approach

Cited by 3 publications

References 147 publications

Obese Asthma Phenotype Is Associated with hsa-miR-26a-1-3p and hsa-miR-376a-3p Modulating the IGF Axis

Obese Asthma Phenotype Is Associated with hsa-miR-26a-1-3p and hsa-miR-376a-3p Modulating the IGF Axis

Epidemiology of the relationship between allergic bronchopulmonary aspergillosis and asthma

Shaping the Future in Rare Lung Diseases: From Imaging to Patient Management

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