Hidden Blue Hazard? LED Lighting and Retinal Damage in Rats

Lougheed, Tim

doi:10.1289/ehp.122-a81

Cited by 24 publications

(15 citation statements)

References 8 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Combination of a blue LED chip and a yellow phosphor is commonly used to generate white light . However, such type of WLED has disadvantages of chromaticity drifts, low color‐rendering index (CRI) and blue light retinal injury due to strong blue spike of 450–500 nm in the white‐light spectrum . Ultraviolet (UV)‐pumped white‐LED devices (UV‐WLEDs) which employ UV‐LED chips to excite suitable combinations of phosphors are potential candidates to improve CRI and reduce the blue light toxicity to an eye of blue chip‐WLEDs .…”

Section: Luminous Efficiencies (Le) Cie Coordinates (X Y) Color Comentioning

confidence: 99%

Mesoporous Aluminum Hydroxide Synthesized by a Single‐Source Precursor‐Decomposition Approach as a High‐Quantum‐Yield Blue Phosphor for UV‐Pumped White‐Light‐Emitting Diodes

et al. 2016

View full text Add to dashboard Cite

Strongly emissive (photoluminescence quantum yield up to 65%), thermally stable aluminum hydroxide blue phosphors are synthesized by a single-source precursor-decomposition approach. Blue-emitting UV-pumped light-emitting diodes (LEDs) based on the aluminum hydroxide phosphor reach luminous efficiency of 27.5 lm W , while UV-white-LEDs integrating blue-emitting aluminum hydroxide and red-emitting CuInS nanocrystals achieve high color-rendering-index values of 94.3 and luminous efficiency of 23.5 lm W .

show abstract

Section: Luminous Efficiencies (Le) Cie Coordinates (X Y) Color Comentioning

confidence: 99%

Mesoporous Aluminum Hydroxide Synthesized by a Single‐Source Precursor‐Decomposition Approach as a High‐Quantum‐Yield Blue Phosphor for UV‐Pumped White‐Light‐Emitting Diodes

et al. 2016

View full text Add to dashboard Cite

show abstract

“…This wavelength corresponds with the visible spectrum that reaches the retina and is one of the main fractions of new white illumination [15,16]. The constant exposure of people in modern developed society to this type of light results in their increased risk of suffering from a variety of ocular disorders [16][17][18][19][20][21]. Moreover, there is some evidence that the action of blue light on the eye is increased when tissues are damaged or in suboptimal conditions, thus, worsening its impact on individuals with pathological conditions [22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Role of PRGF on RPE Cells after Blue Light Insult as a Therapy for Neurodegenerative Diseases

Suárez-Barrio

Olmo-Aguado

García-Pérez

et al. 2020

IJMS

View full text Add to dashboard Cite

Oxidative stress has a strong impact on the development of retinal diseases such as age-related macular degeneration (AMD). Plasma rich in growth factors (PRGF) is a novel therapeutic approach in ophthalmological pathologies. The aim of this study was to analyze the antioxidant effect of PRGF in retinal epithelial cells (EPR) in in vitro and ex vivo retinal phototoxicity models. In vitro analyses were performed on ARPE19 human cell line. Viability and mitochondrial status were assessed in order to test the primary effects of PRGF. GSH level, and protein and gene expression of the main antioxidant pathway (Keap1, Nrf2, GCL, HO-1, and NQO1) were also studied. Ex vivo analyses were performed on rat RPE, and HO-1 and Nrf2 gene and protein expression were evaluated. The results show that PRGF reduces light insult by stimulating the cell response against oxidative damage and modulates the antioxidant pathway. We conclude that PRGF’s protective effect could prove useful as a new therapy for treating neurodegenerative disorders such as AMD.

show abstract

“…[19][20][21][22] A high prevalence of these symptoms in present study could be owing to the fact that we were evaluating this stress among those who had direct exposure to LED devices which are reported to have a dominance of blue spectrum of light which is considered to be harmful for ocular health. [4][5][6][7][8][9][10] As such use of personal devices, employing LED screen, such as mobile phone have been shown to result in higher symptomatic manifestations. Sadagopan et al, who studied this problem exclusively in cell phone using College students found this prevalence to be as high as 80% among those using cell phone for >2 hours per day.…”

Section: Discussionmentioning

confidence: 99%

“…6 The short wavelength of high energy blue light component of LED has the ability to penetrate the retina and bring about irreversible changes as observed in experimental studies. 7,8,9 Interestingly, it has been shown that removal of blue light from the visible spectrum of light could help in decreasing retinal damage after high intensity exposure. 10 Unfortunately, the younger generation has a direct exposure to LED devices either owing to compulsions of gathering more information, illuminating their study table as well as for communication and entertainment purposes or just for pastime.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Digital/Led Device use and Ocular Symptoms: A Cross-Sectional Study in Secondary School Girl Students

Agarwal¹,

Agarwal²

2019

IJCMR

View full text Add to dashboard Cite

Introduction: Use of LED based devices is increasing substantially in recent years, however, these devices could have an adverse effect on ocular health. Study aimed to evaluate the relationship between direct exposure to LED and ocular symptoms. Material and Methods: The data was collected from secondary school students studying in a girls' college at Bareilly during an eye camp organized by Muskaan Foundation. Only girls having known intact vision (BCVA 6-6/6-9) were enrolled in the study. A total of 536 girls were enrolled in the study. Average daily direct exposure <3-4 hours was categorized as unexposed while those having >3-4 hours daytime or 1-2 hrs or more night time exposure were categorized as exposed. The exposed girls were divided into day exposed and night exposed respectively. Ocular symptoms were noted. Chi-square test and ANOVA were calculated using SPSS 21.0 software. Results: Mean age of girls was 17.02±1.42 (Range 15-19) years. A total of 298 (55.5%) had direct exposure to LED. Prevalence of ocular symptoms like headache, pain in eyes, blurring, floaters, burning sensation and eye fatigue was 34.3%, 34.1%, 26.3%, 24.3%, 41.6% and 39% respectively. Total No. of symptomatic girls was 387 (72.2%) A significant increase in ocular symptoms was observed from unexposed to daytime and to night exposed girls (p<0.001). Mean number of total symptoms also showed a significant increasing trend from unexposed to nighttime exposure (p<0.001). Conclusion: Direct LED light exposure for a substantial period, particularly during night time is detrimental to ocular health.

show abstract

Hidden Blue Hazard? LED Lighting and Retinal Damage in Rats

Cited by 24 publications

References 8 publications

Mesoporous Aluminum Hydroxide Synthesized by a Single‐Source Precursor‐Decomposition Approach as a High‐Quantum‐Yield Blue Phosphor for UV‐Pumped White‐Light‐Emitting Diodes

Mesoporous Aluminum Hydroxide Synthesized by a Single‐Source Precursor‐Decomposition Approach as a High‐Quantum‐Yield Blue Phosphor for UV‐Pumped White‐Light‐Emitting Diodes

Antioxidant Role of PRGF on RPE Cells after Blue Light Insult as a Therapy for Neurodegenerative Diseases

Relationship between Digital/Led Device use and Ocular Symptoms: A Cross-Sectional Study in Secondary School Girl Students

Contact Info

Product

Resources

About