HiCDiffusion - diffusion-enhanced, transformer-based prediction of chromatin interactions from DNA sequences
Mateusz Chiliński,
Dariusz Plewczynski
Abstract:Prediction of chromatin interactions from DNA sequence has been a significant research challenge in the last couple of years. Several solutions have been proposed, most of which are based on encoder-decoder architecture, where 1D sequence is convoluted, encoded into the latent representation, and then decoded using 2D convolutions into the Hi-C pairwise chromatin spatial proximity matrix. Those methods, while obtaining high correlation scores and improved metrics, produce Hi-C matrices that are artificial - th… Show more
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