“…Hiccups are usually considered benign as they are self-limited with spontaneous resolution. However, if persistent for more than 48 hours, it can be the result of more threatening etiologies [ 9 ], which include meningitis, encephalitis, stroke, and central nervous system tumors that affect the central component. Afferent and efferent components can be stimulated to cause hiccups in the presence of mediastinal tumors, gastroesophageal reflux disease, esophageal tumors, or induced by drugs like steroids, anti-parkinsonian drugs, and antipsychotic medications.…”