Hiccups as an Adverse Reaction to Cancer Chemotherapy

Takiguchi, Yuichi; Watanabe, Reiko; Nagao, Keiichi; Kuriyama, Takayuki

doi:10.1093/jnci/94.10.772

Cited by 39 publications

(21 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among some patients with cancer, hiccup might be secondary to chemotherapy. A retrospective analysis pointed out that hiccups occurred among 0.39% of chemotherapy treated patients including cisplatin, carboplatin and etoposide etc, particularly among males 42. Cisplatin is often the offending agent inducing hiccup; the postulated mechanism includes initiation of an emetic reflex by releasing 5-hydroxyltryptamine (HT) from the enterochromaffin cells and vagal afferents.…”

Section: Etiology Of Persistent and Intractable Hiccupsmentioning

confidence: 99%

Hiccup: Mystery, Nature and Treatment

Chang¹,

2012

J Neurogastroenterol Motil

158

169

View full text Add to dashboard Cite

Hiccup is the sudden onset of erratic diaphragmatic and intercostal muscle contraction and immediately followed by laryngeal closure. The abrupt air rush into lungs elicits a "hic" sound. Hiccup is usually a self-limited disorder; however, when it is prolonged beyond 48 hours, it is considered persistent whereas episodes longer than 2 months are called intractable. A reflex arc involving peripheral phrenic, vagal and sympathetic pathways and central midbrain modulation is likely responsible for hiccup. Accordingly, any irritant in terms of physical/chemical factors, inflammation, neoplasia invading the arc leads to hiccups. The central causes of hiccup include stroke, space occupying lesions and injury etc, whereas peripheral causes include lesions along the arc such as tumors, myocardial ischemia, herpes infection, gastroesophageal reflux disease and applied instrumentations on human body etc. Besides, various drugs (eg, anti-parkinsonism drugs, anesthetic agents, steroids and chemotherapies etc) are the possible etiology. An effective treatment of persistent hiccup may be established upon the correct diagnosis of lesion responsible for the serious event. The pharmacotherapy of hiccup includes chlorpromazine, gabapentin, baclofen, serotonergic agonists, prokinetics and lidocaine. Non-pharmacological approaches such as nerve blockade, pacing, acupuncture and measures to hold breathing are also successful. Finally, alternative medicines and remedies are convenient to treat hiccups with uncertain effect. In conclusions, hiccup is likely to result from lesions involving the hiccup reflex arc. The lesion may need to be localized correctly for ablative treatment in patients with intractable hiccup. Apart from lesion ablation, drugs acting on reflex arc may be effective, while some other conventional measures may also be tried.

show abstract

Section: Etiology Of Persistent and Intractable Hiccupsmentioning

confidence: 99%

Hiccup: Mystery, Nature and Treatment

Chang¹,

2012

J Neurogastroenterol Motil

158

169

View full text Add to dashboard Cite

show abstract

“…8,9 Hiccups following cytotoxic therapy are more common in men. 10 Hiccups that occur at night have a greater chance of having an organic cause versus a psychogenic cause. 2 A detailed physical examination with particular attention to head and neck structures, chest wall, heart, lungs, abdomen, and central nervous system (CNS) should be performed.…”

Section: Patient Assessmentmentioning

confidence: 99%

Management of Intractable Hiccups

Rizzo

Vitale

Montagnini

2013

Am J Hosp Palliat Care

View full text Add to dashboard Cite

Often thought of as a benign and self-limited condition, hiccups can become persistent or intractable, and thus be associated with substantial morbidity and distress. In such cases, an underlying etiology is often present, and may be overlooked. Debilitating hiccups can present a major challenge to optimal symptom management. Various causes of protracted hiccups have been identified including metabolic abnormalities, central nervous system pathology, malignancy, medications, and disorders attributed to cardiac, pulmonary and gastrointestinal etiologies. We present a case of intractable hiccups in a patient with an advanced hematological malignancy and review specific therapies for the management of persistent hiccups.

show abstract

“…4 Interestingly, drug-induced hiccups are reported more commonly in men than women. [4][5][6] The onset of hiccups may range from minutes to several hours after parenteral drug administration, while with oral medications, the onset may be within hours to a few days following administration. 7 Table 1 presents a list of drugs suspected of causing hiccups.…”

Section: Drugs May Induce Hiccups In Rare Casesmentioning

confidence: 99%

“…7 Table 1 presents a list of drugs suspected of causing hiccups. [2][3][4][5][6][7][8][9][10] This list is mostly based on isolated case reports. Two studies evaluated the relationship between the most frequently suspected agents (i.e, dexamethasone and midazolam) and the onset of hiccups.…”

Section: Drugs May Induce Hiccups In Rare Casesmentioning

confidence: 99%

Drugs May Induce Hiccups in Rare Cases

Giudice¹

2007

Can Pharm J

View full text Add to dashboard Cite

Hiccups as an Adverse Reaction to Cancer Chemotherapy

Cited by 39 publications

References 3 publications

Hiccup: Mystery, Nature and Treatment

Hiccup: Mystery, Nature and Treatment

Management of Intractable Hiccups

Drugs May Induce Hiccups in Rare Cases

Contact Info

Product

Resources

About